%0 Journal Article %T Effect of Portulaca oleraceae L. extracts on the Morphine Dependence in Mice %J Iranian Journal of Basic Medical Sciences %I Mashhad University of Medical Sciences %Z 2008-3866 %A Karimi, Gholamreza %A Ziaee, Toktam %A Nazari, Azam %D 2008 %\ 10/01/2008 %V 10 %N 4 %P 229-232 %! Effect of Portulaca oleraceae L. extracts on the Morphine Dependence in Mice %K Morphine %K Dependence %K Portulaca oleraceae %R 10.22038/ijbms.2008.5235 %X ObjectiveThis study was initiated to investigate the effect of Portulaca oleraceae on morphine dependence in mice.Materials and MethodsDependence was induced using the subcutaneous injections of morphine for 3 days. On the day 4, morphineinjected 2 h prior to intraperitoneal injection of naloxone. The plant extracts ethanolic or aqueousadministered 0.5 h before the final dose of morphine. The number of jumping during the 30 min period after naloxone injection was considered as a measure of withdrawal syndrome.ResultsBoth extracts reduced the jumping episodes dose-dependently. The maximum effect was observed at dosesof 0.28 g/kg and 1.4 g/kg for the aqueous and ethanolic extracts, respectively. Clonidine and extractsdecreased the total activity in locomotion test.ConclusionThese findings indicated that Portulacea oleraceae extracts can decrease morphine dependence in mice. %U https://ijbms.mums.ac.ir/article_5235_66e826e0b859a66a14286b990fa2a3df.pdf