%0 Journal Article %T Improvement effect of Lycium barbarum polysaccharide on sub-health mice %J Iranian Journal of Basic Medical Sciences %I Mashhad University of Medical Sciences %Z 2008-3866 %A Zhao, Rui %A Hao, Wenli %A Ma, Baoling %A Chen, Zhibao %D 2015 %\ 12/01/2015 %V 18 %N 12 %P 1245-1252 %! Improvement effect of Lycium barbarum polysaccharide on sub-health mice %K Anti-fatigue %K Antioxidant %K Immunity %K Lycium bararum %K Polysaccharide %K Sub-health %R 10.22038/ijbms.2015.6281 %X Objective(s):Sub-health has been described as a chronic condition of unexplained deteriorated physiological function, which falls between health and illness. In the present study, we evaluated the effects of Lycium barbarum polysaccharide (LBP), a polysaccharide fraction purified from Lycium barbarum (L. barbarum) on the sub-health mice. Materials and Methods:The sub-health model mice were built through compound factors. The mice were given intragastric administration of LBP at low dose (50 mg•kg-1) and high dose (100 mg•kg-1), respectively. After LBP treatment for 4 weeks, the antioxidant ability, enhancing immune function and anti-fatigue activity were detected. Results:The results showed that LBP could enhance antioxidant ability in sub-health mice. LBP could effectively improve immunity of sub-health mice and protect the immune organs, such as thymus. In addition, LBP showed anti-fatigue ability in sub-health mice. Conclusion:LBP could improve sub-health state caused from composite factor through three aspects, such as increasing antioxidant ability, promoting T lymphocyte proliferation, inhibiting thymus lymphocyte apoptosis, and alleviating fatigue. %U https://ijbms.mums.ac.ir/article_6281_da32b60fb9b6ae600b4ae6528a5ebdbb.pdf