%0 Journal Article %T Prednison provokes serum and vasoactive substances in a mice model of immune thrombocytopenia %J Iranian Journal of Basic Medical Sciences %I Mashhad University of Medical Sciences %Z 2008-3866 %A Zhang, Ling %A Chen, Ke %A Li, Tiantian %A He, Hao %A Hou, Li %A Wu, Xiaoyong %A Sun, Yanping %A Zheng, Lei %A Chen, Zhixiong %A Qin, Bei %A Chen, Xinyi %A Tian, Shaodan %D 2016 %\ 09/01/2016 %V 19 %N 9 %P 1010-1015 %! Prednison provokes serum and vasoactive substances in a mice model of immune thrombocytopenia %K Immune thrombocytopenia %K Mice %K Norepinephrine VIP %K β-EP %K 5-HT %R 10.22038/ijbms.2016.7602 %X Objective(s): The main objective of this study was to investigate the variations of β-endorphin (β-EP), vasoactive intestinal peptide (VIP), serotonin (5-HT) and norepinephrine (NE) of immune thrombocytopenia (ITP) mice as well as the regulatory mechanism of prednison. Materials and Methods: Sixty BALB/c mice were randomly divided into control group, model group and prednison intervention group. ITP mice model was duplicated by injecting with glycoprotein-antiplatelet serum (GP-APS) except in control group. After ITP disease model was successful established, prednison was used in prednison intervention group. The β-EP, VIP, 5-HT and NE contents of ITP mice were detected by enzyme linked immunosorbent assay (ELISA). Results:Compared with the values in control group, the detection values of VIP and 5-HT in model group declined, while the detection values of β-EP and NE increased. Compared with prednison intervention group, the detection values of VIP and 5-HT in model group increased, while the detection values of β-EP and NE showed no significant change. Conclusion: In this study, the β-EP, VIP, 5-HT and NE contents in ITP mice injected with GP-APS were changed by prednison. It shows that prednison as the first-line therapy for ITP with effective hemostasis function is likely to increasing the contents of VIP and 5-HT. These results suggest the therapeutic value of prednison for the treatment of ITP. %U https://ijbms.mums.ac.ir/article_7602_fbe8c0a4eab88ae50f406bf77aa7f249.pdf