Mashhad University of Medical Sciences
Iranian Journal of Basic Medical Sciences
2008-3866
2008-3874
16
3
2013
03
01
Human T Lymphotropic Virus Type I (HTLV-I) Oncogenesis: Molecular Aspects of Virus and Host Interactions in Pathogenesis of Adult T cell Leukemia/Lymphoma (ATL)
197
195
EN
Sanaz
Ahmadi Ghezeldasht
Research Centre for HIV/AIDS, HTLV and Viral Hepatitis, Iranian Academic Centre for Education, Culture & Research (ACECR), Mashhad Branch, Mashhad,
Iran
Abbas
Shirdel
Inflammation and Inflammatory diseases research Centre, Medical School, Mashhad University of Medical Science, Mashhad, Iran.
shirdela@mums.ac.ir
Mohammad Ali
Assarehzadegan
Department of Immunology, Faculty of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
Tahereh
Hassannia
Internal Medicine Dept, Medical School, Arak University of Medical Sciences, Arak- Iran
Hosian
Rahimi
Inflammation and Inflammatory diseases research Centre, Medical School, Mashhad University of Medical Science, Mashhad, Iran.
Rahele
Miri
Research Centre for HIV/AIDS, HTLV and Viral Hepatitis, Iranian Academic Centre for Education, Culture & Research (ACECR), Mashhad Branch, Mashhad,
Iran
S. A. Rahim
Rezaee
Immunology Research Centre, Mashhad University of Medical Sciences, Mashhad, Iran
10.22038/ijbms.2013.730
<br/> <br/><span style="color: #221e1f; font-size: xx-small;">The study of tumor viruses paves the way for understanding the mechanisms of virus pathogenesis, including those involved in establishing infection and dissemination in the host tumor affecting immune-compromised patients. The processes ranging from viral infection to progressing malignancy are slow and usually insufficient for establishment of transformed cells that develop cancer in only a minority of infected subjects. Therefore, viral infection is usually not the only cause of cancer, and further environmental and host factors, may be implicated.</span> <br/>HTLV-I, in particular, is considered as an oncovirus cause of lymphoproliferative disease such as adult T cell leukemia/lymphoma (ATL) and disturbs the immune responses which results in HTLV-I associated meylopathy/tropical spastic parapresis (HAM/TSP). HTLV-I infection causes ATL in a small proportion of infected subjects (2-5%) following a prolonged incubation period (15-30 years) despite a strong adaptive immune response against the virus. <br/> <br/>Overall, these conditions offer a prospect to study the molecular basis of tumorgenicity in mammalian cells. In this review, the oncogencity of HTLV-I is being considered as an oncovirus in context of ATL. <br/> <br/>
Adult T Cell Leukemia/Lymphoma
HTLV-I
Oncoviruses
Oncogenecity
https://ijbms.mums.ac.ir/article_730.html
https://ijbms.mums.ac.ir/article_730_ce43c51b7801c1cde620ed21daf34791.pdf
Mashhad University of Medical Sciences
Iranian Journal of Basic Medical Sciences
2008-3866
2008-3874
16
3
2013
03
01
A Systematic Review for Estimation of HTLV-I Infection in the Blood
Donors of Iran
196
201
EN
Mohammad Reza
Hedayati-Moghaddam
Research Centre for HIV/AIDS, HTLV and Viral Hepatitis, Iranian Academic Centre for Education, Culture & Research (ACECR), Mashhad Branch, Mashhad,
Iran
drhedayati@yahoo.com
10.22038/ijbms.2013.731
Keywords:
HTLV-I infection
Systematic review
Meta-analysis
Blood donors
Iran
https://ijbms.mums.ac.ir/article_731.html
https://ijbms.mums.ac.ir/article_731_e7c34ed74c86e9fb69682979463322d7.pdf
Mashhad University of Medical Sciences
Iranian Journal of Basic Medical Sciences
2008-3866
2008-3874
16
3
2013
03
01
The Impact of Immune Response on HTLV-I in HTLV-I-Associated
Myelopathy/Tropical Spastic Paraparesis (HAM/TSP)
202
208
EN
Houshang
Rafatpanah
Inflammation and Inflammatory Diseases Research Centre, Mashhad University of Medical Sciences, Mashhad, Iran
Reza
Farid Hosseini2
Allergy Research Centre, Mashhad University of Medical Sciences, Mashhad, Iran
Seyed Hassan
Pourseyed
Inflammation and Inflammatory Diseases Research Centre, Mashhad University of Medical Sciences, Mashhad, Iran
10.22038/ijbms.2013.732
<br/> <br/><span style="color: #221e1f; font-size: xx-small;">Human T lymphotropic virus type I (HTLV-I) is a retrovirus which is associated with adult T cells leukaemia (ATL) and HTLV-I-associated myelopathy/tropical spastic paraparesis (HAM/TSP) in a minority of HTLV-I-infected individuals. It is not clear why a minority of HTLV-I-infected individuals develop HAM/TSP and majority remains lifelong carriers. It seems that the interaction between the virus and the immune response plays an important role in HTLV-I-associated diseases. Although the role of the immune response in HTLV-I pathogenesis is not fully understood, however it seems that the efficacy of the immune response which is involved in controlling or limiting of viral persistence determines the outcome of HTLV-I-associated diseases. Here we discuss the role of innate and adaptive immune response and also the risk factors contribute to the observed differences between HAM/TSP patients and asymptomatic HTLV-I carriers. </span><br/>
Keywords:
Human T lymphotropic virus type I
(HTLV-I)
HTLV-I-associated myelopathy/tropical
spastic paraparesis (HAM/TSP)
Immune response
https://ijbms.mums.ac.ir/article_732.html
https://ijbms.mums.ac.ir/article_732_38783eb4f48c2da14376a7122cce98a1.pdf
Mashhad University of Medical Sciences
Iranian Journal of Basic Medical Sciences
2008-3866
2008-3874
16
3
2013
03
01
“HTLV-I Infection” Twenty-Year Research in Neurology Department of
Mashhad University of Medical Sciences
209
214
EN
Ali
Shoeibi
Assistant Professor of Neurology, Mashhad University of Medical Sciences
shoeibia@gmail.com
Mohammdmahdi
Etemadi
Professor of Neurology, Mashhad University of Medical Sciences
Amir
Moghaddam Ahmadi
Neurologist, Rafsanjan University of Medical Sciences
Mona
Amini
Resident of Neurology, Mashhad University of Medical Sciences
Reza
Boostani
0000-0001-7998-9592
Assistant Professor of Neurology, Mashhad University of Medical Sciences
boostanir@mums.ac.ir
10.22038/ijbms.2013.733
<br/> <br/><span style="color: #221e1f; font-size: xx-small;">Human T-cell lymphotropic virus (HTLV) types 1 and 2 belong to the Oncorna group of retroviridae, a large family of viruses, grouped initially by pathogenic features, but later revised on the basis of genome structure and nucleotide sequence. HTLV-I was the first discovered human retrovirus to be associated with a malignancy in 1980. The malignancy, first described by Uchiyama and co-workers in southwestern Japan, was named Adult T-cell Leukemia/Lymphoma (ATL) and characterized with cutaneous and respiratory involvement, hepatosplenomegaly, lymphadenopathy and various metabolic abnormalities such as hypercalcemia. The HTLV-I has been known to be endemic to certain parts of Iran like the province of Khorasan in the northeast since 1990, with a 2.3% prevalence rate of infection. The main manifestations of HTLV-I infection are neurologic and hematologic (such as ATL) disorders, but it has also other manifestations such as uveitis, arthritis, dermatitis, vitiligo and lymphocytic alveolitis. Its main neurologic manifestation is a chronic progressive myelopathy that is referred to HTLV-I Associated Myelopathy (HAM) in Japan and Tropical Spastic Paraparesis (TSP) in Caribbean. But other disorders such as peripheral neuropathy, polyradiculoneuropathy, myopathy, peripheral facial paresis, and so on have been reported too. In this review we wish to give some brief information on the different aspects (including epidemiology, pathogenesis and pathology, clinical findings, and treatment) of HTLV-I infection according to our twenty-year researches. The department of neurology of Mashhad University of Medical Sciences has been a pioneer in researches on HTLV-I in the last twenty years. </span><br/>
Keywords:
HTLV-I
Iran
Spastic paraparesis
Tropical
https://ijbms.mums.ac.ir/article_733.html
https://ijbms.mums.ac.ir/article_733_37591426797a2b2b7bc4e80be8e5a959.pdf
Mashhad University of Medical Sciences
Iranian Journal of Basic Medical Sciences
2008-3866
2008-3874
16
3
2013
03
01
Comparison of HTLV-I Proviral Load in Adult T Cell Leukemia/Lymphoma
(ATL), HTLV-I-Associated Myelopathy (HAM-TSP) and Healthy Carriers
215
219
EN
Mohammad Mehdi
Akbarin
Inflammation and inflammatory research centre, Medical School, Mashhad University of Medical Science, Mashhad- Iran
Hossein
Rahimi
Inflammation and inflammatory research centre, Medical School, Mashhad University of Medical Science, Mashhad- Iran
2 Internal medicine Dept. Medical School, Mashhad University of Medical Science, Mashhad- Iran
Tahereh
HassanNia
Internal Medicine Dept, Amir al Moemenin Hospital, Arak University of Medical Sciences.
Ghazaleh
ShojaRazavi
Internal medicine Dept. Medical School, Mashhad University of Medical Science, Mashhad- Iran
Faezeh
Sabet
Navid Medical Lab, Mashhad- Iran
Abbas
Shirdel
Inflammation and inflammatory research centre, Medical School, Mashhad University of Medical Science, Mashhad- Iran
2 Internal medicine Dept. Medical School, Mashhad University of Medical Science, Mashhad- Iran
shirdela@mums.ac.ir
10.22038/ijbms.2013.734
Keywords:
HTLV-I
HAM/TSP
ATL
HTLV-I proviral load
https://ijbms.mums.ac.ir/article_734.html
https://ijbms.mums.ac.ir/article_734_03443fc99b2890506befe70ef66281df.pdf
Mashhad University of Medical Sciences
Iranian Journal of Basic Medical Sciences
2008-3866
2008-3874
16
3
2013
03
01
Effects of Danazol on Clinical Improvement of Patients with Human
T-cell Lymphotropic Virus Type I Associated Myelopathy/Tropical Spastic
Paraparesis (HAM/TSP ): A Placebo-Controlled Clinical Trial
220
223
EN
Reza
Boostani
0000-0001-7998-9592
Department of Neurology, Mashhad University of Medical Sciences, Mashhad, Iran
boostanir@mums.ac.ir
Hamidreza
Saber
2General Practitioners, Mashhad University of Medical Sciences, Mashhad, Iran
Mohammadmahdi
Etemadi
Department of Neurology, Mashhad University of Medical Sciences, Mashhad, Iran
10.22038/ijbms.2013.735
Danazol
HTLV-I
Myelopathy
https://ijbms.mums.ac.ir/article_735.html
https://ijbms.mums.ac.ir/article_735_ec74df18ccaa8e5c26976e95d58af953.pdf
Mashhad University of Medical Sciences
Iranian Journal of Basic Medical Sciences
2008-3866
2008-3874
16
3
2013
03
01
Human T Lymphotropic Virus Type I (HTLV-I) is a Risk Factor for Coronary
Artery Disease
224
227
EN
Mahmoud
Shabestari
Preventive Cardiovascular Care Research Centre
Farahzad
Jabbari
Allergy Research Centre
Reza
Farid Hosseni
Immunology Research Centre
S. A. Rahim
Rezaee
Inflammation and Inflammation diseases Research Centre
Yousef
Gharivani
Preventive Cardiovascular Care Research Centre
Narges
Valizadeh
Inflammation and Inflammation diseases Research Centre
Mansoreh
Sobhani
Allergy Research Centre
Toktam
Moghiman
Preventive Cardiovascular Care Research Centre
t_moghiman@yahoo.co.uk
Farnaz
Mozayani
Immunology Research Centre
10.22038/ijbms.2013.736
Keywords:
Coronary Artery Disease (CAD)
HTLV-I
Risk factor
https://ijbms.mums.ac.ir/article_736.html
https://ijbms.mums.ac.ir/article_736_a169d8995aff53623990f2c234d048b1.pdf
Mashhad University of Medical Sciences
Iranian Journal of Basic Medical Sciences
2008-3866
2008-3874
16
3
2013
03
01
Outcome of Intravenous Immunoglobulin-Transmitted HTLV-I,
Hepatitis B, Hepatitis C, and HIV infections
228
231
EN
Mohsen
Foroughipour
Neurology Department, Ghaem Hospital, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
Farahzad
Jabbari Azad
Allergy Research Centre, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
Reza
Farid hosseini
Immunology Research Centre, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
Abbas
Shirdel
Internal Medicine Department, Ghaem Hospital, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
shirdela@mums.ac.ir
Amir Reza
Khalighi
Internal Medicine Department, Ghaem Hospital, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
Hadis
Yousefzadeh
Immunology Research Centre, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
Homa
Sadri
Allergy Research Centre, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
Toktam
Moghiman
Preventive Cardiovascular Care Research Centre , Mashhad University of Medical Sciences, Mashhad, Iran
t_moghiman@yahoo.co.uk
Hossein
Hekmatkhah
Preventive Cardiovascular Care Research Centre , Mashhad University of Medical Sciences, Mashhad, Iran
10.22038/ijbms.2013.737
Keywords:
Hepatitis B virus
Hepatitis C virus
Immune Deficiency
Intravenous Immunoglobulin
https://ijbms.mums.ac.ir/article_737.html
https://ijbms.mums.ac.ir/article_737_1e68a6b3ba7978ed7b8f30fc9be76aac.pdf
Mashhad University of Medical Sciences
Iranian Journal of Basic Medical Sciences
2008-3866
2008-3874
16
3
2013
03
01
Population-based Seroprevalence of HTLV-I Infection in Golestan
Province, South East of Caspian Sea, Iran
232
235
EN
Khodaberdi
Kalavi
Infectious Diseases Research Centre, Golestan University of Medical Sciences, Gorgan, Iran
Abdolvahab
Moradi
Infectious Diseases Research Centre, Golestan University of Medical Sciences, Gorgan, Iran
Alijan
Tabarraei
Infectious Diseases Research Centre, Golestan University of Medical Sciences, Gorgan, Iran
alijant@yahoo.com
10.22038/ijbms.2013.738
Keywords:
HTLV-I
Seroprevalence
ELISA
Western Blot
Golestan
Iran
https://ijbms.mums.ac.ir/article_738.html
https://ijbms.mums.ac.ir/article_738_dc485c0c1d923794b94d8303d937fe11.pdf
Mashhad University of Medical Sciences
Iranian Journal of Basic Medical Sciences
2008-3866
2008-3874
16
3
2013
03
01
No Evidence of HTLV-II Infection Among Immonoblot Indeterminate
Samples Using Nested PCR in Mashhad, Northeast of Iran
236
241
EN
Houshang
Rafatpanah
Research Centre for HIV/AIDS, HTLV and Viral Hepatitis, Iranian Academic Centre for Education, Culture & Research (ACECR), Mashhad Branch,
Mashhad, Iran
2 Inflammation and Inflammatory Diseases Research Centre, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
Farhad
Fathimoghadam
Research Centre for HIV/AIDS, HTLV and Viral Hepatitis, Iranian Academic Centre for Education, Culture & Research (ACECR), Mashhad Branch,
Mashhad, Iran
Majid
Shahabi
Research Centre for the Iranian Blood Transfusion Organization (IBTO), Tehran, Iran
Iman
Eftekharzadeh
Research Centre for HIV/AIDS, HTLV and Viral Hepatitis, Iranian Academic Centre for Education, Culture & Research (ACECR), Mashhad Branch,
Mashhad, Iran
Mohammadreza
Hedayati-Moghaddam
Research Centre for HIV/AIDS, HTLV and Viral Hepatitis, Iranian Academic Centre for Education, Culture & Research (ACECR), Mashhad Branch,
Mashhad, Iran
Narges
Valizadeh
Inflammation and Inflammatory Diseases Research Centre, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
Mohsen
Tadayon
Research Centre for HIV/AIDS, HTLV and Viral Hepatitis, Iranian Academic Centre for Education, Culture & Research (ACECR), Mashhad Branch,
Mashhad, Iran,
SeyyedAliakbar
Shamsian
Research Centre for HIV/AIDS, HTLV and Viral Hepatitis, Iranian Academic Centre for Education, Culture & Research (ACECR), Mashhad Branch,
Mashhad, Iran
Hamidreza
Bidkhori
Research Centre for HIV/AIDS, HTLV and Viral Hepatitis, Iranian Academic Centre for Education, Culture & Research (ACECR), Mashhad Branch,
Mashhad, Iran
Raheleh
Miri
Research Centre for HIV/AIDS, HTLV and Viral Hepatitis, Iranian Academic Centre for Education, Culture & Research (ACECR), Mashhad Branch,
Mashhad, Iran
Ali
Bazarbachi
Department of Internal Medicine, American University of Beirut, Beirut, 10 Lebanon
10.22038/ijbms.2013.739
HTLV-I
HTLV-II
Iran,Mashhad
PCR
Seroindeterminate
Western blot
https://ijbms.mums.ac.ir/article_739.html
https://ijbms.mums.ac.ir/article_739_d37558d08037d6720edba0b528b52382.pdf
Mashhad University of Medical Sciences
Iranian Journal of Basic Medical Sciences
2008-3866
2008-3874
16
3
2013
03
01
Evaluation of HTLV-I and HCV Prevalence in Non-Hodgkin’s Lymphoma
242
246
EN
Maryam
Rastin
Immunology Research Centre, BuAli Research Institute, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
Ali Reza
Khoee
Department of Pathology, Imam Reza Hospital, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
Nafiseh
Tabasi
Immunology Research Centre, BuAli Research Institute, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
Saeed
Ziaolhagh
Immunology Research Centre, BuAli Research Institute, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
Elham
Esmaeeli
Immunology Research Centre, BuAli Research Institute, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
Shahrzad
Zamani
Immunology Research Centre, BuAli Research Institute, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
Mahdieh
Khazaee
Immunology Research Centre, BuAli Research Institute, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
Mahmoud
Mahmoudi
Immunology Research Centre, BuAli Research Institute, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
10.22038/ijbms.2013.740
Keywords:
Human T Lymphotropic Virus
Hepatitis C virus
Non-Hodgkin’s lymphoma
https://ijbms.mums.ac.ir/article_740.html
https://ijbms.mums.ac.ir/article_740_0dfa9f2c7451de1e95ece67e272bba65.pdf
Mashhad University of Medical Sciences
Iranian Journal of Basic Medical Sciences
2008-3866
2008-3874
16
3
2013
03
01
Designing a Human T-Lymphotropic Virus Type 1 (HTLV-I) Diagnostic
Model Using the Complete Blood Count
247
251
EN
Masoumeh
Sarbaz
Department of Medical Informatics, School of Medicine and Faculty Member of Health Information Technology and Medical Records Department
Omid
Pournik
Department of Medical informatics, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran and Deputy for Health, Shahid Beheshti
University of Medical Sciences, Tehran, Iran
Leila
Ghalichi
Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
Khalil
Kimiafar
Mashhad University of Medical Sciences, Mashhad,
Iran and Department of Health Information Management, Faculty of Health Management and Information Sciences, Tehran University of Medical
Sciences, Tehran, Iran
Amir Reza
Razavi
Department of Medical informatics, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
10.22038/ijbms.2013.741
CHAID
Machine Learning,Decision Tree
HTLV-I
https://ijbms.mums.ac.ir/article_741.html
https://ijbms.mums.ac.ir/article_741_899f4be187910820934a458d915390e5.pdf
Mashhad University of Medical Sciences
Iranian Journal of Basic Medical Sciences
2008-3866
2008-3874
16
3
2013
03
01
Is there any Association Between Human Lymphotropic Virus Type I
(HTLV-I) Infection and Systemic Lupus Erythematosus? An Original
Research and Literature Review
252
257
EN
Abbas
Shirdel
Department of Internal Medicine, Ghaem Hospital, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
shirdela@mums.ac.ir
Kamila
Hashemzadeh
Rheumatic Diseases Research Centre, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
Maryam
Sahebari
Rheumatic Diseases Research Centre, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
Houshang
Rafatpanah
Rheumatic Diseases Research Centre, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
MohammadReza
Hatef
Rheumatic Diseases Research Centre, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
Zahra
Rezaieyazdi
Rheumatic Diseases Research Centre, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
Zahra
Mirfeizi
Rheumatic Diseases Research Centre, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
mirfeiziz@mums.ac.ir
Reza
FaridHosseini
Asthma and Allergy Research Centre, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
10.22038/ijbms.2013.742
HTLV-I
Human T Lymphotropic Virus Type 1
Systemic Lupus Erythematosus
SLE
https://ijbms.mums.ac.ir/article_742.html
https://ijbms.mums.ac.ir/article_742_48df691a7eae0336f4f2d1921b99b647.pdf
Mashhad University of Medical Sciences
Iranian Journal of Basic Medical Sciences
2008-3866
2008-3874
16
3
2013
03
01
Association of IL-10 Gene Polymorphisms and Human T Lymphotropic
Virus Type I-Associated Myelopathy/tropical Spastic Paraparesis in
North-East of Iran (Mashhad)
258
263
EN
Abbas
Shirdel
Department of Hematology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
shirdela@mums.ac.ir
Mahmoud Reza
Azarpazhooh
Neurology Department, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
Maryam
Sahebari
Rheumatic Diseases Research Centre, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
Mohsen
Ghanbari
Immunology Research Centre, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
ghanbarim1@mums.ac.ir
Seyedeh Zahra
Mirfeizi
Rheumatic Diseases Research Centre, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
Ian
Hutchinson
Immunology Research Group, Faculty of Life Sciences, The University of Manchester, United Kingdom
Aghigh
Ziaee
Immunology Research Centre, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
Houshang
Rafatpanah
Inflammation and Inflammatory Disease Research Centre, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
10.22038/ijbms.2013.743
<br/><span style="color: #221e1f; font-size: xx-small;"><span style="color: #221e1f; font-size: xx-small;">The underlying mechanisms leading to the development of human T-cell lymphotropic virus type I (HTLV-I) associated myelopathy/tropical spastic paraparesis (HAM/TSP) in HTLV-I infected individuals are not fully understood. Host genetic factors appear to be involved as risk factors for developing HAM/TSP. We investigated the possible contribution of interleukin-10 (IL-10) as a risk factor to HAM/TSP by comparing frequencies of promoter region single nucleotide polymorphisms in HTLV-I infected Iranian patients who either remained asymptomatic or developed HAM/TSP and asymptomatic HTLV-I carriers. Healthy, uninfected individuals from the same region served as healthy controls. Significant differences were observed in the distribution of IL-10 promoter alleles and genotypes at position -819 and -592 between HAM/TSP patients and healthy controls (</span></span><em><span style="font-family: CapitoliumNews,CapitoliumNews; color: #221e1f; font-size: xx-small;"><em><span style="font-family: CapitoliumNews,CapitoliumNews; color: #221e1f; font-size: xx-small;"><em><span style="font-family: CapitoliumNews,CapitoliumNews; color: #221e1f; font-size: xx-small;">P=</span></em></span></em></span></em><span style="color: #221e1f; font-size: xx-small;"><span style="color: #221e1f; font-size: xx-small;">0.01), and between HTLV-I carriers and healthy controls (</span></span><em><span style="font-family: CapitoliumNews,CapitoliumNews; color: #221e1f; font-size: xx-small;"><em><span style="font-family: CapitoliumNews,CapitoliumNews; color: #221e1f; font-size: xx-small;"><em><span style="font-family: CapitoliumNews,CapitoliumNews; color: #221e1f; font-size: xx-small;">P=</span></em></span></em></span></em><span style="color: #221e1f; font-size: xx-small;"><span style="color: #221e1f; font-size: xx-small;">0.02). The frequency of the low IL-10 producer haplotype (-1082*A, -819*T, -592*A) was significantly associated with HTLV-I carriage or HAM/TSP compared with healthy controls (</span></span><em><span style="font-family: CapitoliumNews,CapitoliumNews; color: #221e1f; font-size: xx-small;"><em><span style="font-family: CapitoliumNews,CapitoliumNews; color: #221e1f; font-size: xx-small;"><em><span style="font-family: CapitoliumNews,CapitoliumNews; color: #221e1f; font-size: xx-small;">P=</span></em></span></em></span></em> <br/><span style="color: #221e1f; font-size: xx-small;">0.02 and 0.01, respectively). Our results suggest that IL-10 -819*T and -592*A alleles are significant risk factors for developing HTLLV-I infection but do not appear to convey additional risk for developing HAM/TSP </span><br/>
Gene
HAM/TSP
HTLV-I
IL-10
Polymorphisms
https://ijbms.mums.ac.ir/article_743.html
https://ijbms.mums.ac.ir/article_743_7b94ae244c6e751cdc2702394e9ccf52.pdf
Mashhad University of Medical Sciences
Iranian Journal of Basic Medical Sciences
2008-3866
2008-3874
16
3
2013
03
01
Association between HLA Class I Alleles and Proviral Load in HTLV-I
Associated Myelopathy/Tropical Spastic Paraperesis (HAM/TSP) Patients
in Iranian Population
264
267
EN
Mahdi
Taghaddosi
HTLV-I Foundation, Ghaem Hospital, Mashhad University of Medical Sciences, Mashhad, Iran
S. A. Rahim
Rezaee
Immunology Research Centre, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
Houshang
Rafatpanah
Inflammation and inflammatory Disease Research Centre, Faculty of Medicine ,Mashhad University of Medical Sciences, Mashhad, Iran
Taraneh
Rajaei
Inflammation and inflammatory Disease Research Centre, Faculty of Medicine ,Mashhad University of Medical Sciences, Mashhad, Iran
Reza
Farid Hosseini
Allergy Research Centre, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
Valizadeh
Narges
Immunology Research Centre, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
3 Inflammation and inflammatory Disease Research Centre, Faculty of Medicine ,Mashhad University of Medical Sciences, Mashhad, Iran
10.22038/ijbms.2013.744
HTLV-I
HAM/TSP
HLA
Proviral load
https://ijbms.mums.ac.ir/article_744.html
https://ijbms.mums.ac.ir/article_744_7d45fe62bf9a98c94573ccfec238e19a.pdf
Mashhad University of Medical Sciences
Iranian Journal of Basic Medical Sciences
2008-3866
2008-3874
16
3
2013
03
01
Human T-lymphotropic Virus Type I (HTLV-I) Proviral Load and Clinical
Features in Iranian HAM/TSP Patients
268
272
EN
Rosita
Vakili
HTLV-I Foundation, Ghaem Hospital, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
rosita_vakily@yahoo.com
Faezeh
Sabet
HTLV-I Foundation, Ghaem Hospital, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
Sanaz
Ahmadi Ghezeldasht
Centre of Pathological and Medical Diagnostic Services, Iranian Academic Centre for Education, Culture & Research (ACECR), Mashhad Branch, Mashhad,
Iran
Reza
Boostani
0000-0001-7998-9592
Department of Neurology, Ghaem Hospital, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
boostanir@mums.ac.ir
Houshang
rafatpanah
Inflammation and Inflammatory Diseases Research Centre, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
Ali
Shamsian
Centre of Pathological and Medical Diagnostic Services, Iranian Academic Centre for Education, Culture & Research (ACECR), Mashhad Branch, Mashhad,
Iran
S. A. Rahim
Rezaee
Immunology Research Centre, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
10.22038/ijbms.2013.745
HTLV-I
HAM/TSP
HTLV-I clinical features
Iran
Proviral load
https://ijbms.mums.ac.ir/article_745.html
https://ijbms.mums.ac.ir/article_745_ac3bb994fdd493cc66a9c9e031ed3be2.pdf
Mashhad University of Medical Sciences
Iranian Journal of Basic Medical Sciences
2008-3866
2008-3874
16
3
2013
03
01
Cutaneous Manifestations in HTLV-I Positive Blood Donors
273
277
EN
Mohammad Javad
Yazdanpanah
Cutaneous Leishmanaisis Research Center, Department of Dermatology,School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
Masoud
Maleki
Cutaneous Leishmanaisis Research Center, Department of Dermatology,School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
Nasaibe
Joneidi
Cutaneous Leishmanaisis Research Center, Department of Dermatology,School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
Amir Reza
Khalighi
Department of Internal Medicine ,Ghaem Hospital, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
Mahmoud Reza
Azarpazhooh
Department of Neurology, Ghaem Hospital, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
Mohammad
Khajedaluee
Department of Social Medicine, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
khajedalueem@mums.ac.ir
Farahnaz
Tehranian
Research Centre of Iranian Blood Transfusion Organization, Khorasan Razavi, Mashhad, Iran
Majid
Shahabi
Research Centre of Iranian Blood Transfusion Organization, Khorasan Razavi, Mashhad, Iran
Mohammad
Esmaeil Khayami
Research Centre of Iranian Blood Transfusion Organization, Khorasan Razavi, Mashhad, Iran
Fatemeh
Livani
Cutaneous Leishmanaisis Research Center, Department of Dermatology,School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
10.22038/ijbms.2013.746
Blood donors
Dermatologic manifestation
Human T-cell lymphotrophic virus type-I
https://ijbms.mums.ac.ir/article_746.html
https://ijbms.mums.ac.ir/article_746_36303146db54e69a5be394c947c4c8ed.pdf
Mashhad University of Medical Sciences
Iranian Journal of Basic Medical Sciences
2008-3866
2008-3874
16
3
2013
03
01
Study of the Association Between Human T-cell Lymphotropic Virus
Type I Infection and Lichen Planus
278
280
EN
Mahnaz
Banihashemi
Cutaneous Leishmanaisis Research Center, Department of Dermatology, Ghaem Hospital, School of Medicine, Mashhad University of Medical Sciences,
Mashhad, Iran
Bita
Kiafar
Cutaneous Leishmanaisis Research Center, Department of Dermatology, Ghaem Hospital, School of Medicine, Mashhad University of Medical Sciences,
Mashhad, Iran
Mohammad
Ashkezari
1 Cutaneous Leishmanaisis Research Center, Department of Dermatology, Ghaem Hospital, School of Medicine, Mashhad University of Medical Sciences,
Mashhad, Iran
Noorieh
sharifi
Department of Pathology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
Nasibe
Pishgooei
Cutaneous Leishmanaisis Research Center, Department of Dermatology, Ghaem Hospital, School of Medicine, Mashhad University of Medical Sciences,
Mashhad, Iran
Fatemah
Livani
Cutaneous Leishmanaisis Research Center, Department of Dermatology, Ghaem Hospital, School of Medicine, Mashhad University of Medical Sciences,
Mashhad, Iran
Reyhaneh
Bazargani
Research Centre of Iranian Blood Transfusion Organisation, Khorasan Razavi, Mashhad, Iran
Mohammad
Esmail Khayami
Research Centre of Iranian Blood Transfusion Organisation, Khorasan Razavi, Mashhad, Iran
MohammadJavad
Yazdanpanah
Cutaneous Leishmanaisis Research Center, Department of Dermatology, Ghaem Hospital, School of Medicine, Mashhad University of Medical Sciences,
Mashhad, Iran
10.22038/ijbms.2013.747
Human T-cell Lymphotropic Virus Type 1
Lichen Planus
Skin disease
https://ijbms.mums.ac.ir/article_747.html
https://ijbms.mums.ac.ir/article_747_0badecabf3a5c064f6721dc57371cc22.pdf
Mashhad University of Medical Sciences
Iranian Journal of Basic Medical Sciences
2008-3866
2008-3874
16
3
2013
03
01
Association between HTLV-I Infection and Chronic Lupoid Leishmaniasis
281
283
EN
Fakhrozaman
Pezeshkpoor
Cutaneous Leishmanaisis Research Center,Ghaem Hospital, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
Seyed Abdol Rahim
Rezaei
HTLV-I Foundation, Immunology Department, Mashhad University of Medical Sciences, Mashhad, Iran
Abbas
Shirdel
Department of Internal Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
shirdela@mums.ac.ir
Mohammad
Khajedaluee
Department of Social Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
khajedalueem@mums.ac.ir
Mansoreh
Alizadeh
Cutaneous Leishmanaisis Research Center,Ghaem Hospital, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
Mohammad Javad
Yazdanpanah
Cutaneous Leishmanaisis Research Center,Ghaem Hospital, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
10.22038/ijbms.2013.748
Cutaneous lupoid leishmaniasis
Cutaneous leishmaniasis
Human T cell lymphotropic virus type I
https://ijbms.mums.ac.ir/article_748.html
https://ijbms.mums.ac.ir/article_748_b09b7a33a8e94d438ac868d79349d31c.pdf