TY - JOUR ID - 11548 TI - Generation of motor neurons from human amygdala-derived neural stem-like cells JO - Iranian Journal of Basic Medical Sciences JA - IJBMS LA - en SN - 2008-3866 AU - Ghasemi, Sepideh AU - Aligholi, Hadi AU - Koulivand, Pir Hossain AU - Jafaraian, Maryam AU - Hosseini Ravandi, Hassan AU - Khaleghi Ghadiri, Maryam AU - Gorji, Ali AD - Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran AD - Department of Neuroscience, School of Advanced Medical Sciences and Technologies, Shiraz University of Medical Sciences, Shiraz, Iran AD - Department of Neurosurgery, Westfälische Wilhelms-Universität Münster, Münster, Germany Y1 - 2018 PY - 2018 VL - 21 IS - 11 SP - 1155 EP - 1160 KW - Brain KW - Hippocampus KW - Intractable epilepsy KW - Motor Neuron KW - Neural stem cells DO - 10.22038/ijbms.2018.29587.7146 N2 - Objective(s): Among several cell sources, adult human neural stem/progenitor cells (hNS/PCs) have been considered outstanding cells for performing mechanistic studies in in vitro and in vivo models of neurological disorders as well as for potential utility in cell-based therapeutic approaches. Previous studies addressed the isolation and culture of hNS/PCs from human neocortical and hippocampal tissues. However, little data are available on hNS/PCs obtained from the adult human amygdala.Materials and Methods: The present study explored the capacity of the amygdala harvested from resected brain tissues of patients with medically refractory epilepsy to generate neurosphere-like bodies and motor neuron-like cells.Results: Although the proliferation process was slow, a considerable amount of cells was obtained after the 3rd passage. In addition, the cells could generate motor neuron-like cells under appropriate culture conditions. Conclusion: Isolation and culture of these cells enable us to improve our knowledge of the role of the amygdala in some neurological and psychological disorders and provide a novel source for therapeutic cell transplantation. UR - https://ijbms.mums.ac.ir/article_11548.html L1 - https://ijbms.mums.ac.ir/article_11548_a7bde3b2eda8806114262f5bd4e373cf.pdf ER -