TY - JOUR ID - 11550 TI - Paeoniflorin has anti-inflammation and neurogenesis functions through nicotinic acetylcholine receptors in cerebral ischemia-reperfusion injury rats JO - Iranian Journal of Basic Medical Sciences JA - IJBMS LA - en SN - 2008-3866 AU - Ko, Cheng-Hang AU - Huang, Chun-Ping AU - Lin, Yi-Wen AU - Hsieh, Ching-Liang AD - Department of Chinese Medicine, China Medical University Hospital, Taichung 40447, Taiwan AD - Chinese Medicine Research Center, China Medical University, Taichung 40402, Taiwan Y1 - 2018 PY - 2018 VL - 21 IS - 11 SP - 1174 EP - 1178 KW - Apoptosis KW - Inflammation KW - Neurogenesis KW - Nicotinic acetylcholine receptor KW - Paeoniflorin KW - Stroke DO - 10.22038/ijbms.2018.30371.7322 N2 - Objective(s): Paeoniflorin (PF) has anti-oxidation, anti-inflammation, anti-apoptosis, and neuroprotection pharmacological effects against ischemic injury. The aim of the present study was to investigate the neuroprotection mechanisms of PF in cerebral ischemia-reperfusion injury rats.Materials and Methods: We established an animal model of cerebral infarct by occlusion of the middle cerebral artery for 15 min, followed by reperfusion, and PF was administered 24 hr later (20 mg/kg, intraperitoneally for 6 days) after reperfusionResults: Treatment with PF reduced the neurological deficit score, improved motor function, decreased cell counts of nicotinic acetylcholine receptor (nAChR) α4β2 immunoreactive cells, and increased cell counts of nAChR α7. Furthermore, PF administration suppressed neuronal apoptosis and promoted neurogenesis.Conclusion: PF rescued neurological deficit and underlying mechanisms were inhibition of neurological apoptosis and inflammation by nAChRs. UR - https://ijbms.mums.ac.ir/article_11550.html L1 - https://ijbms.mums.ac.ir/article_11550_88d2801f544e912ce7bf5b229a388c53.pdf ER -