TY - JOUR ID - 11691 TI - Effects of citral on oxidative stress and hepatic key enzymes of glucose metabolism in streptozotocin/high-fat-diet induced diabetic dyslipidemic rats JO - Iranian Journal of Basic Medical Sciences JA - IJBMS LA - en SN - 2008-3866 AU - Mishra, Chetna AU - Khalid, Monowar AU - Fatima, Naazmin AU - Singh, Babita AU - Tripathi, Dinesh AU - Waseem, Mohammad AU - Mahdi, Abbas Ali AD - Department of Biochemistry, King George’s Medical University, Lucknow-226003, Uttar Pradesh, India AD - Department of Environmental Science, Integral University, Lucknow-226021, Uttar Pradesh, India AD - Department of Biochemistry, King George’s Medical University, Lucknow-226003, Uttar Pradesh, India Lucknow- 226003, Uttar Pradesh, India AD - Department of Physiology, King George’s Medical University, Lucknow- 226003, Uttar Pradesh, India Y1 - 2019 PY - 2019 VL - 22 IS - 1 SP - 49 EP - 57 KW - Carbohydrate metabolism KW - Citral KW - Diabetes KW - Dyslipidemia KW - Enzymes KW - Oxidative stress KW - Streptozotocin DO - 10.22038/ijbms.2018.26889.6574 N2 - Objective(s): Phytochemicals such as polyphenols, alkaloids, and terpenoids, protect against the development of early stages and complications of diabetes mellitus according to various reports. The aim of this study was to measure the anti-dyslipidemic and anti-diabetic effects of Citral on high-fat-diet (HFD) and streptozotocin (STZ) induced diabetic dyslipidemic rats and to see also its effect on carbohydrate metabolic regulatory enzymes in the liver.  Materials and Methods: Rats were kept on a high-fat diet for 2 weeks, then diabetes was induced by a single dose of STZ (35 mg/kg/BW, intraperitoneally), Citral was administered orally at a dose of 45 mg/kg/BW for 28 days to diabetic rats. Blood glucose, plasma insulin, and lipid profile in blood were studied. Antioxidant activities were assayed in the liver, pancreas, and adipose tissues. Carbohydrate metabolic enzymes of the liver were also studied in diabetic dyslipidemic rats.Results: The results of this study confirmed that administration of Citral significantly (P<0.05) decreased the blood glucose level and increased plasma insulin in diabetic rats.  Citral also improved oxidative markers along with anti-oxidative enzymes of the liver, adipose tissue, and pancreas in the HFD/STZ group. Citral also regulated the activity of the glucose-metabolic enzymes in the liver. The results of the present study were compared to Glibenclamide, which is a standard oral drug for lowering the blood sugar.  Conclusion: Results may show that Citral possesses anti-dyslipidemic activity as well as anti-diabetic activity and also regulates the enzyme activity of glycolytic and gluconeogenic processes in the liver. UR - https://ijbms.mums.ac.ir/article_11691.html L1 - https://ijbms.mums.ac.ir/article_11691_3994a2d9f6b44bae36ea9ff9952b35da.pdf ER -