TY - JOUR ID - 13016 TI - Effects of nano-copper on maize yield and inflammatory response in mice JO - Iranian Journal of Basic Medical Sciences JA - IJBMS LA - en SN - 2008-3866 AU - Hien, Le AU - Trang, Phi AU - Phuong, Pham AU - Tam, Pham AU - Xuan, Nguyen AD - Institute of Genome Research, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet, Cau Giay, Hanoi, Vietnam AD - Nuclear Medicine and Oncology Center, Bach Mai Hospital, 78 Giai Phong, Hanoi, Vietnam AD - Hanoi Open University, 101 Nguyen Hien, Hai Ba Trung, Hanoi, Vietnam Y1 - 2019 PY - 2019 VL - 22 IS - 7 SP - 781 EP - 788 KW - ALT KW - AST KW - Copper KW - Leukocytes KW - Maize DO - 10.22038/ijbms.2019.35787.8526 N2 - Objective(s): Copper (Cu) is an essential dietary supplement in animal feeds, which plays an important role in maintaining the balance of all living organisms. Copper nanoparticles (nCu) participate in catalysing activities of multiple antioxidant/defensive enzymes and exerts pro-inflammatory and pro-apoptotic effects on systemic organs and tissues. The present study explored whether nCu affects maize growth and yield and grain mineral nutrients as well as physiological functions in mice. Materials and Methods: Maize seeds were treated with nCu (20 mg/kg and 1000 mg/kg dry weight (DW)) and their grain productions were used for mouse feed. For testing of autoimmune response, mice were treated with nCu at concentration of 2 mg/l and 1000 mg/l and ultimately serum biochemical indicators, numbers and activation of immune cells infiltrated in mouse spleens were examined. Results: Treatment of maize seeds with nCu at dose of 20 mg/kg DW, but not 1000 mg/kg DW enhanced germination rate, plant growth and grain yield as well as grain mineral nutrients as compared to control group. Importantly, administration of mice with 1000 mg/l nCu resulted in their morphological change due to excessive accumulation of nCu in liver and blood, leading to inflammatory responses involved in upregulated expression of serum biochemical indicators of liver and kidney as well as increased infiltration and activation of splenic immune cells. Conclusion: nCu concentration at 20 mg/kg DW facilitated the morphological and functional development of maize plants, whose production was safe to feed mice. UR - https://ijbms.mums.ac.ir/article_13016.html L1 - https://ijbms.mums.ac.ir/article_13016_8f41c852ccc368c06f03687abe4cb502.pdf ER -