TY - JOUR ID - 13434 TI - Behavioral and electrophysiological aspects of cognition in neonate rats lactated by morphine addicted mothers JO - Iranian Journal of Basic Medical Sciences JA - IJBMS LA - en SN - 2008-3866 AU - Aghighi, Fatemeh AU - Mohammadifar, Mojgan AU - Banafshe, Hamidreza AU - Salami, Mahmoud AU - Talaei, Sayyed Alireza AD - Physiology Research Center, Institute for Basic Sciences, Kashan University of Medical Sciences, Kashan, Iran Y1 - 2019 PY - 2019 VL - 22 IS - 9 SP - 1059 EP - 1064 KW - Hippocampus KW - Lactation KW - Maze learning KW - Morphine KW - Rats KW - Spatial Memory KW - Synaptic plasticity DO - 10.22038/ijbms.2019.36892.8789 N2 - Objective(s): In addition to genetic factors, environmental phenomena during postnatal age highly affect development and, in turn, function of the brain. The present work evaluates if morphine consumption during lactation period influences the spatial performances and synaptic plasticity in rats at neonatal period of age. Materials and Methods: Three groups of mothers were subcutaneously administered by 5 (M5), 10 (M10) or 20 (M20) mg/kg morphine every 12 hours during the lactation period. At 45 days old, their offspring were introduced to Morris water maze for assessment of spatial learning and memory. Basic field excitatory post-synaptic potentials (fEPSPs) were recorded in the CA1 area of hippocampus and, then, long term potentiation (LTP) was induced by tetanic stimulation. Results: We found that the M10 and M20 rats spent more time and traveled longer distance to find the hidden platform of maze when compared to the control animals (PConclusion: The present study provides behavioral and electrophysiological proofs for negative effect of morphine on the hippocampal-related function in the neonatally morphine-exposed rats. UR - https://ijbms.mums.ac.ir/article_13434.html L1 - https://ijbms.mums.ac.ir/article_13434_6a007a5d774d407c77ea631868f81343.pdf ER -