TY - JOUR ID - 13549 TI - The protective effects of silymarin on ischemia-reperfusion injuries: A mechanistic review JO - Iranian Journal of Basic Medical Sciences JA - IJBMS LA - en SN - 2008-3866 AU - akbari-korhkheyli, Vahid AU - Abbaszadeh-Goudarzi, kazem AU - Nejati-Laskokalayeh, Mohaddeseh AU - Zarpou, Setareh AU - khonakdar-tarsi, Abbas AD - Student Research Committee, Mazandaran University of Medical Sciences, Sari, Iran AD - Cellular and Molecular Research Center, Sabzevar University of Medical Sciences, Sabzevar, Iran AD - Department of Biochemistry-Biophysics and Genetics, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran Y1 - 2019 PY - 2019 VL - 22 IS - 9 SP - 968 EP - 976 KW - Inflammation KW - Ischemia KW - Oxidative stress KW - Reperfusion KW - Silymarin DO - 10.22038/ijbms.2019.34284.8147 N2 - Ischemia-reperfusion injuries (IRI) occur in different clinical conditions such as stroke, trauma, organ transplantation, and so on. Ischemia damages mainly arise from oxygen depletion in tissues. The lack of oxygen as the last acceptor of electron in the respiratory chain causes a decrease in ATP production and eventually leads to disruption of membrane transport, acidosis, cellular edema and membrane distortion of organelles, and cells. Reperfusion can intensify ischemic injuries by the infiltration of inflammatory cells and also oxygen and calcium overloading. Since the tissue antioxidant contents decreased due to increased generation of reactive oxygen species (ROS) during IRI, the application of antioxidants is considered an appropriate strategy to ameliorate IRI. Silymarin constitutes about 70–80% of silybum marianum dry extract and is known as a strong free radical scavenger with anti-inflammatory properties. In several studies, silibinin as a major component of Silymarin could provide protective effects in various tissue IRI by different mechanisms such as scavenging free radicals, decreasing inflammatory cytokines, inhibiting cellular death, and increasing the expression of antioxidant enzymes. To clarify functional mechanisms, the present article evaluates studies about silymarin effects in different tissues IRI. UR - https://ijbms.mums.ac.ir/article_13549.html L1 - https://ijbms.mums.ac.ir/article_13549_e6055f23e870fa4c228582377d3c9a25.pdf ER -