TY - JOUR ID - 16864 TI - Could high serum folate be associated with adverse effects? JO - Iranian Journal of Basic Medical Sciences JA - IJBMS LA - en SN - 2008-3866 AU - Ghorbani, Mahla AU - Baharara, Javad AU - Kerachian, Mohammad Amin AD - Department of Biology, Faculty of Sciences, Mashhad Branch, Islamic Azad University, Mashhad, Iran AD - Research Center for Animal Development Applied Biology & Biology Department, Mashhad Branch, Islamic Azad University, Mashhad, Iran AD - Medical Genetics Research Center, Mashhad University of Medical Sciences, Mashhad, Iran Y1 - 2020 PY - 2020 VL - 23 IS - 12 SP - 1499 EP - 1500 KW - Agouti KW - Epigenetic KW - folic acid KW - Methylation KW - MTHFR KW - Pregnant DO - 10.22038/ijbms.2020.51870.11762 N2 - Folate is an important water-soluble vitamin that is presented naturally in foods in particular vegetables, fruits, and whole grains. To which extent is this vitamin needed in our daily regimen is not fully known. Several studies have indicated that many complications, such as megaloblastic anemia, cardiovascular disease, neural tube defects, and numerous cancers, occur in humans when the body becomes deficient in folic acid. On the other hand, a few studies have shown thier concerns regarding the supplementation of folic acid, resulting in the development of existing tumors and alteration of normal patterns of DNA methylation. Although there is no clear evidence of aberrant DNA methylation and gene expression changes in response to “high” levels of folate  or folic acid intake, there are still some concerns. Therefore, its adverse effects especially on fetus and later stages of life should be carefully investigated. UR - https://ijbms.mums.ac.ir/article_16864.html L1 - https://ijbms.mums.ac.ir/article_16864_a36cc1dfc4df50852414bd6a96c9a4b5.pdf ER -