TY - JOUR ID - 17053 TI - Rapid releasing naproxen Liqui-Pellet using effervescent agent and neusilin US2 JO - Iranian Journal of Basic Medical Sciences JA - IJBMS LA - en SN - 2008-3866 AU - Lam, Matthew AU - Asare-Addo, Kofi AU - Nokhodchi, Ali AD - Pharmaceutics Research Laboratory, Arundel Building, School of Life Sciences, University of Sussex, Brighton, UK AD - Department of Pharmacy, University of Huddersfield, Huddersfield, HD1 3DH, UK Y1 - 2021 PY - 2021 VL - 24 IS - 1 SP - 108 EP - 115 KW - Coating Excipients Liqui KW - Mass system Rapid release Solubility X KW - ray tomography DO - 10.22038/ijbms.2020.51697.11729 N2 - Objective(s): Liqui-Mass technology has shown promising advantages in terms of commercial production and formulation manipulation. This study attempts to further explore the potential of enhanced drug release of effervescent Liqui-Pellet by optimizing certain parameters. Materials and Methods: In the current study, pellets containing co-solvent, naproxen, coating and carrier materials were prepared via extrusion and spheronisation (Liqui-Pellet). Parameters investigated included polysorbate 80 concentration (as a co-solvent), water content and the presence or absence of neusilin US2 as part of the new binary carrier mixture approach. Results: It was found that the success of the Liqui-Pellet production was determined by the amount of polysorbate 80 and water used, where above a certain limit, agglomeration occurred, and the formulation failed. Liqui-Pellet formulation showed an excellent flow, narrow size distribution and was robust to pass friability testing. The key findings in the investigation were that the Liqui-Pellet was capable of a remarkably fast drug release, and 100% drug release achieved within 20 min at pH 1.2, wherein naproxen has been known to be practically insoluble in such pH.Conclusion: Liqui-Pellets display the potential to enhance explosive dissolution where a combination of effervescent powders and binary carriers with the high surface area were used. Furthermore, X-ray microtomography revealed that the pellets were very uniform and homogenous. UR - https://ijbms.mums.ac.ir/article_17053.html L1 - https://ijbms.mums.ac.ir/article_17053_07930ab716e0547c35ee7e101bfa74d1.pdf ER -