TY - JOUR ID - 17818 TI - Effects of the diphenylheptane extract of Alpinia officinarum rhizomes on ethanol-induced gastric ulcers in mice JO - Iranian Journal of Basic Medical Sciences JA - IJBMS LA - en SN - 2008-3866 AU - Lin, Kaiwen AU - Qu, Huijuan AU - Tan, Yinfeng AU - Deng, Tang AU - Gao, Bingmiao AU - Wei, Na AD - School of Pharmacy, Hainan Medical University, Haikou, China Y1 - 2021 PY - 2021 VL - 24 IS - 5 SP - 657 EP - 665 KW - Anti-inflammation KW - Antioxidant KW - Diphenylheptane KW - Gastric protection KW - Gastric ulcer DO - 10.22038/ijbms.2021.53644.12068 N2 - Objective(s): Experimental studies have revealed that Alpinia officinarum Hance (Zingiberaceae) exhibits a gastrointestinal protective effect. The present study aimed to investigate the effects of diphenylheptanes (DPHs) extracted from A. officinarum rhizomes on ethanol-induced gastric ulcers in BALB/c mice.Materials and Methods: A total of 60 female BALB/c mice were divided into six groups as follows: negative control, which received sodium carboxymethyl cellulose; positive control, which received ethanol; treatment control, which received ethanol+ranitidine; ethanol+high dose of DPHs; ethanol+medium dose of DPHs; ethanol+low dose of DPHs. Different doses of DPHs were administered orally once daily for seven consecutive days before the animals were subjected to ethanol-induced gastric ulcers.Results: Various doses of DPHs significantly reduced Gastric ulcers index when compared with the positive control. DPHs treatments and treatment control increased the activity of superoxide dismutase; decreased the levels of inflammatory mediators, malondialdehyde, motilin, and gastrin; decreased the activity of inducible nitric oxide synthase and cyclooxygenase-2; and inhibited the expression of Toll-like receptor 4, myeloid differentiation factor 88, and nuclear factor-κB at the protein and mRNA levels. In addition, DPHs inhibited the expression of transient receptor potential vanilloid 1, calcitonin gene-related peptide, and increased the expression of substance P at the protein and mRNA levels. Conclusion: The protective effect of DPHs extracted from A. officinarum rhizomes against ethanol-induced gastric damages in mice suggests that the extract can be used as an auxiliary supplement for the prevention and treatment of gastric ulcers. UR - https://ijbms.mums.ac.ir/article_17818.html L1 - https://ijbms.mums.ac.ir/article_17818_4447d8fd48b0b7bca24294554101284a.pdf ER -