TY - JOUR ID - 18852 TI - Inhibition of aluminum chloride-induced amyloid Aβ peptide accumulation and brain neurodegeneration by Bougainvillea spectabilis flower decoction JO - Iranian Journal of Basic Medical Sciences JA - IJBMS LA - en SN - 2008-3866 AU - Abdel-Salam, Omar AU - El-Shamarka, Marwa AU - Youness, Eman AU - Shaffie, Nermeen AD - Department of Toxicology and Narcotics, National Research Centre, Cairo, Egypt AD - Department of Medical Biochemistry, National Research Centre, Cairo, Egypt AD - Department of Pathology, National Research Centre, Cairo, Egypt Y1 - 2021 PY - 2021 VL - 24 IS - 10 SP - 1437 EP - 1445 KW - Aluminum chloride KW - Amyloid Aβ KW - Bougainvillea spectabilis- flowers KW - Interleukin-6 KW - Neurodegeneration KW - Oxidative stress KW - Paraoxonase DO - 10.22038/ijbms.2021.58246.12940 N2 - Objective(s): To investigate the potential therapeutic effect of Bougainvillea spectabilis flower decoction on aluminum chloride (AlCl3)-induced neurotoxicity. Materials and Methods: Rats received daily intraperitoneal injections of AlCl3 at 10 mg/kg for two months and were treated with B. spectabilis decoction at 50 or 100 mg/kg or saline during the 2nd month of the study. The control group received saline. Brain malondialdehyde (MDA), nitric oxide (NO), reduced glutathione (GSH), acetylcholinesterase (AChE), amyloid Aβ peptide, and interleukin-6 (IL-6) concentrations and paraoxonase-1 (PON-1) activity were determined and brain histology was done. Behavioral and neurological testing included Morris water maze (WMZ), Y maze, and wire hanging. Results: Compared with saline controls, AlCl3 significantly increased brain MDA and NO along with decreased GSH and PON-1 activity. It also increased AChE, IL-6, and amyloid Aβ concentrations. AlCl3 impaired motor strength and memory performance and caused brain neurodegeneration. B. spectabilis decoction given at 50 or 100 mg/kg protected against the biochemical and histopathological alterations evoked by AlCl3 by alleviating the increase in MDA and NO, and decrease in GSH and PON-1 activity.  B. spectabilis decoction showed no significant effect on AChE but markedly decreased IL-6 and amyloid Aβ in the brain of AlCl3-treated rats. It also restored memory performance and motor strength, and protected against AlCl3-induced neurodegeneration.Conclusion: These results suggest that B. spectabilis flower decoction might prove of value in the treatment of Alzheimer’s disease. UR - https://ijbms.mums.ac.ir/article_18852.html L1 - https://ijbms.mums.ac.ir/article_18852_552d25586838b6ee38e61be59e40a5b9.pdf ER -