TY - JOUR ID - 19479 TI - Chronic treatment with coenzyme Q10 mitigates the behavioral dysfunction of global cerebral ischemia/reperfusion injury in rats JO - Iranian Journal of Basic Medical Sciences JA - IJBMS LA - en SN - 2008-3866 AU - Fatemi, Iman AU - Saeed Askari, Pooya AU - Hakimizadeh, Elham AU - Kaeidi, Ayat AU - Esmaeil-Moghaddam, Sogand AU - Pak-Hashemi, Mohammad AU - Allahtavakoli, Mohammad AD - Research Center of Tropical and Infectious Diseases, Kerman University of Medical Sciences, Kerman, Iran AD - Student Research Committee, Rafsanjan University of Medical Sciences, Rafsanjan, Iran AD - Physiology-Pharmacology Research Center, Research Institute of Basic Medical Sciences, Rafsanjan University of Medical Sciences, Rafsanjan, Iran Y1 - 2022 PY - 2022 VL - 25 IS - 1 SP - 39 EP - 45 KW - Brain Injuries KW - Free radicals KW - Ischemia/Reperfusion KW - Q10 KW - Rat DO - 10.22038/ijbms.2022.57630.12865 N2 - Objective(s): The Ischemia/reperfusion (I/R) phenomenon has a critical role in brain injuries induced by some kinds of stroke. The current study investigates the effects of Coenzyme Q10 (Q10) on global cerebral I/R in rats. Materials and Methods: Fifty male Wistar rats were used in this study. The global cerebral I/R was induced by obstructing both common carotid arteries for 20 min and the animals were treated with Q10 (200 mg/kg; PO.) for 6 weeks. Depressive and anxiety-like behaviors were assessed using the elevated plus-maze and forced swimming test, respectively. Working and spatial learning and memory were assessed by the Y-maze continuous alternation task and Morris water maze. The brain tissues were evaluated for brain edema, brain-derived neurotrophic factor (BDNF) levels, and superoxide dismutase (SOD) activities. Results: Our results indicated that global cerebral I/R increased anxiety and depression-like behavior as well as reduced cognitive performance. Moreover, the levels of BDNF and activities of SOD are reduced in stroke animals. Chronic post-stroke treatment with Q10 decreased brain edema. Furthermore, Q10 administration reduced anxiety and depressive-like behavior as well as cognitive impairments in stroke animals. Q10 also increased the SOD activities and BDNF levels in the brain tissues of stroke animals. Conclusion: Finally, we can conclude that using Q10 supplementation may be beneficial against the global cerebral I/R complications. UR - https://ijbms.mums.ac.ir/article_19479.html L1 - https://ijbms.mums.ac.ir/article_19479_633a23e10bdc1197b280a50703e94750.pdf ER -