TY - JOUR ID - 20424 TI - Tetratricopeptide repeat domain 9A knockout induces social anxiety and impairs offense behaviors in female mice JO - Iranian Journal of Basic Medical Sciences JA - IJBMS LA - en SN - 2008-3866 AU - Yu, Wing Shan AU - Guan, Li AU - Tan, Shawn Zheng Kai AU - Shrestha, Smeeta AU - Or, Yu Zuan AU - Lufkin, Thomas AU - Lin, Valerie Chun Ling AU - Lim, Lee Wei AD - Neuromodulation Laboratory, School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, P.R. China AD - School of Biological Sciences, Nanyang Technological University, 50 Nanyang Avenue, Singapore AD - Department of Biology, Clarkson University, Potsdam, New York, United States Y1 - 2022 PY - 2022 VL - 25 IS - 6 SP - 698 EP - 703 KW - Aggression KW - Anxiety KW - Behavioral tests KW - Social behavior KW - Tetratricopeptide repeat domain 9A (TTC9A) DO - 10.22038/ijbms.2022.63044.13932 N2 - Objective(s): The involvement of tetratricopeptide repeat domain 9A (TTC9A) in anxiety-like behaviors through estrogen action has been reported in female mice, this study further investigated its effects on social anxiety and aggressive behaviors.Materials and sMethods: Using female Ttc9a knockout (Ttc9a-/-) mice, the role of TTC9A in anxiety was investigated in non-social and social environments through home-cage emergence and social interaction tests, respectively, whereas aggressive behaviors were examined under the female intruder test. Results: We observed significant social behavioral deficits with pronounced social and non-social anxiogenic phenotypes in female Ttc9a-/- mice. When tested for aggressive-like behaviors, we found a reduction in offense in Ttc9a-/- animals, suggesting that TTC9A deficiency impairs the offense responses in female mice. Conclusion: Future study investigating mechanisms underlying the social anxiety-like behavioral changes in Ttc9a-/- mice may promote the understanding of social and anxiety disorders.  UR - https://ijbms.mums.ac.ir/article_20424.html L1 - https://ijbms.mums.ac.ir/article_20424_76575e564dba606ffd9b4878f9ce4cad.pdf ER -