TY - JOUR ID - 2245 TI - Hormonal and metabolic effects of polyunsaturated fatty acid (omega-3) on polycystic ovary syndrome induced rats under diet JO - Iranian Journal of Basic Medical Sciences JA - IJBMS LA - en SN - 2008-3866 AU - Ouladsahebmadarek, Elaheh AU - Khaki, Arash AU - Khanahmadi, Sharareh AU - Ahmadi Ashtiani, Hamidreza AU - Paknejad, Pooya AU - Ayubi, Mohammad Reza AD - Women’s Reproductive Health Research Center, Tabriz University of Medical Sciences, Tabriz, Iran AD - Department of Pathology, Tabriz Branch, Islamic Azad University, Tabriz, Iran AD - Department of Biochemistry, Islamic Azad University, Pharmaceutical, Tehran, Iran Y1 - 2014 PY - 2014 VL - 17 IS - 2 SP - 123 EP - 127 KW - Catalaze (CAT) KW - Follicle stimulating hormone (FSH) KW - Glutathione peroxidase (GPX) KW - Omega-3 KW - Polycystic ovary (PCO) KW - Super oxide dismutase (SOD) KW - Testosterone DO - 10.22038/ijbms.2014.2245 N2 - Objective(s): PCOS (polycystic ovary syndrome) produces symptoms in approximately 5% to 10% of women of reproductive age (12–45 years old). It is thought to be one of the leading causes of female subfertility. This study aimed to confirm the role of nutrition containing omega-3 (polyunsaturated fatty acid) on control of experimental PCO induced by estradiol-valerat in rats. Materials and Methods: Wistar female rats (n=40) were allocated into control (n=10) and test groups (n= 30), test group was subdivided into 3 groups: G1, received omega-3 (240 mg/kg/orally/daily); G2 and G3 groups were induced PCO by single injection of estradiol-valerate (16 mg/kg/IM). Group 3 received omega-3 (240 mg/kg/orally/daily) and low carbohydrate feeding for 60 subsequent days; on sixtieth day 5 ml blood samples and ovarian tissues of all rats in the group were removed and prepared for biochemical and hormonal analysis. Results: Catalase, GPX (Glutathione peroxidase), SOD (Superoxide dismutase) in groups that received omega-3showed higher levels, but MDA (malondialdehyde) level was significantly decreased (P<0.05) in comparison with other experimental groups. Ovarian weights in both experimental and control groups were similar (P<0.05). Level of serum FSH (follicle stimulating hormone) was decreased, but level of testosterone was significantly increased (P<0.05) in PCO group in comparison with control and omega-3 groups. Conclusion: Results revealed that administration of omega-3 plus lower carbohydrate food significantly controlled   PCO syndrome and balanced FSH and testosterone. UR - https://ijbms.mums.ac.ir/article_2245.html L1 - https://ijbms.mums.ac.ir/article_2245_ab05951f0c21d1f49c4af9420ca8d902.pdf ER -