TY - JOUR ID - 2790 TI - Evaluation of urinary enzymes in newborns treated with gentamicin JO - Iranian Journal of Basic Medical Sciences JA - IJBMS LA - en SN - 2008-3866 AU - Mohammadi Karakani, Ali AU - Asgharzadeh Haghighi, Solmaz AU - Ghazi-Khansari, Mahmoud AU - Seyed-Ebrahimi, Afsaneh AU - Zeighami-Mohammadi, Sharareh AD - Alborz Hospital, Social Security Organization, Karaj, Iran 2 Institute of Biochemistry and Biophysics, University of Tehran, Tehran, Iran AD - Alborz Hospital, Social Security Organization, Karaj, Iran AD - Departments of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran AD - Nursing and Midwifery, Islamic Azad University of Karaj, Iran Y1 - 2014 PY - 2014 VL - 17 IS - 5 SP - 391 EP - 395 KW - Biomarker KW - Gentamicin KW - Newborn KW - Urine DO - 10.22038/ijbms.2014.2790 N2 - Objective(s): In recent years, there has been an increasing amount of study on early diagnosis of kidney injury through sensitive and specific biomarkers. We examined the practical applicability of the urinary levels of NAG (N-acetyl-β-D-glucosaminidase), AP (alkaline phosphatase), and LDH (lactate dehydrogenase) as renal dysfunction screening biomarkers in full and pre-term newborns treated with gentamicin. Materials and Methods: Fourteen pre-term and fifteen full-term newborns who received gentamicin for suspected infections were enrolled. Serum and urine specimens were obtained before the zero days and after gentamicin infusion on the 1st, 3rd, and 5th days of treatment.  Results: In full-term newborns a significant increase in urinary NAG, LDH, AP after 5 days of gentamicin administration compared with control group was noted (P<0.05, PP<0.01; respectively). Conclusion: Our findings indicate that urinary enzymes may be useful in full-term newborns as a non-invasive method for evaluation of tubular function. UR - https://ijbms.mums.ac.ir/article_2790.html L1 - https://ijbms.mums.ac.ir/article_2790_4a3b64a6fac10d48ecea01c907948e5f.pdf ER -