TY - JOUR ID - 3197 TI - Effect of Scurrula atropurpurea on nitric oxide, endothelial damage, and endothelial progenitor cells of DOCA-salt hypertensive rats JO - Iranian Journal of Basic Medical Sciences JA - IJBMS LA - en SN - 2008-3866 AU - Athiroh, Nour AU - Permatasari, Nur AU - Sargowo, Djanggan AU - Widodo, M Aris AD - Department of Biology, Faculty of Mathematic and Natural Sciences, Islamic University of Malang, Malang, East Java, Indonesia AD - Department of Pharmacology, Faculty of Medicine University of Brawijaya, Malang, East Java, Indonesia AD - Department of Cardiology and Vascular Medicine, Saiful Anwar General Hospital, Faculty of Medicine, University of Brawijaya, Malang, East Java, Indonesia Y1 - 2014 PY - 2014 VL - 17 IS - 8 SP - 622 EP - 625 KW - Endothelial damage KW - Endothelial prgenitor cells KW - Hypertensive KW - Nitric oxide DO - 10.22038/ijbms.2014.3197 N2 - Objective(s):To know whether Scurrula atropurpurea is able to modulate total plasma nitrate/nitrite levels, decrease endothelial damage, and increase endothelial progenitor cells (EPCs) in hypertensive rats. Materials and Methods: The rats were divided in 5 groups: control (normotensive) group, Desoxy cortico sterone (DOCA)-salt hypertensive group, and three DOCA-salt hypertensive groups. All 5 groups received methanolic extract of S. atropurpurea (MESA) at a dosage of 50; 100; and 200 mg/KgBW. Serum nitric oxide (NO) was assayed by colorimetric. Circulating endothelial cells (CECs) and EPCs were assayed using flow cytometry. Results: The administration of MESA100 and MESA200 elevated the total plasma nitrate/nitrite levels but cannot reach the level in control group.  MESA100 and MESA200 also elevated the EPCs number compared with hypertensive group. The administration of MESA significantly (P< 0.05) decreased the CECs number compared to hypertensive groups. Conclusion: Methanolic extract of S. atropurpurea is able to modulate total plasma nitrate/nitrite levels and diminish endothelial damage via increasing EPCs. UR - https://ijbms.mums.ac.ir/article_3197.html L1 - https://ijbms.mums.ac.ir/article_3197_4ff8cf1f6dba0e12682154480b9eb093.pdf ER -