TY - JOUR ID - 3456 TI - Association between HLA-DQB1 alleles and HAM/TSP patients in Khorasan Province JO - Iranian Journal of Basic Medical Sciences JA - IJBMS LA - en SN - 2008-3866 AU - Tafreshian, Amir Reza AU - Etemadi, Mehdi AU - Farid-Hosseini, Reza AU - Salhi, Mansoor AU - Tavakkol Afshari, Jalil AD - Immunology Research Group, Bu-Ali Research Institute, Mashhad University of Medical Sciences, Mashhad, Iran AD - Neurology Department and HTLVI Foundation, Ghaem Medical Center, Mashhad University of Medical Sciences, Mashhad, Iran AD - Allergy Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran AD - Genetics Department School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran Y1 - 2014 PY - 2014 VL - 17 IS - 10 SP - 798 EP - 801 KW - HLA KW - HLA-DQB1 KW - HAM/TSP KW - HTLV-1 KW - PCR-SSP DO - 10.22038/ijbms.2014.3456 N2 - Objective(s): HTLVI-1 is the first human retrovirus with limited endemic regions in the world. The epidemiological studies have shown that the genetic background and immune response to the virus have a significant role in HTLV-I-associated diseases.  Among the genes are involved in HTLV-I infection, the role of human leukocytes antigen (HLA) have been studied in different population. In the present study we examined the association between HLA-DQB1 alleles and HTLV-I infection in HAM/TSP patients, HTLV-I carriers and healthy controls in north east of Iran, Mashhad. Materials and Methods:The blood samples of 16 patients with HAM/TSP, 20 HTLV-1 carriers, and 30 healthy individuals were taken and DNA was extracted by salting out method.  HLA-DQB1 typing was performed using PCR-SSP method and the frequency of HLA-DQB1 alleles were compared by Fischer Exact Test. Results:There was a significant difference between HAM/TSP patients and healthy controls in the frequency of HLA-DQB1*07 (P=0.004, RR=7). Furthermore, we found that possession of HLA- DQB1*02 or HLA-DQB1*05 increased the risk of disease 1.5 times. Conclusion: The data presented here suggest that both HLA-DQB1*07 and HLA-DQB1*06 are associated with disease development. UR - https://ijbms.mums.ac.ir/article_3456.html L1 - https://ijbms.mums.ac.ir/article_3456_db24c5d4a1ca88ab99a639b07c0f9ae2.pdf ER -