TY - JOUR ID - 4542 TI - Evaluation of cutaneous wound healing activity of Malva sylvestris aqueous extract in BALB/c mice JO - Iranian Journal of Basic Medical Sciences JA - IJBMS LA - en SN - 2008-3866 AU - Afshar, Mohammad AU - Ravarian, Behdad AU - Zardast, Mahmoud AU - Moallem, Seyed Adel AU - Hasanpour Fard, Mohammad AU - Valavi, Masoomeh AD - Department of Anatomy, Faculty of Medicine, Birjand University of Medical Sciences, Birjand, Iran AD - Department of Medical Science, Faculty of Medicine, Birjand University of Medical Sciences, Birjand, Iran AD - Department of Pathology, Birjand University of Medical Sciences, Birjand, Iran AD - Medical Toxicology Research Centre, Mashhad University of Medical Sciences, Mashhad, Iran AD - Department of Pharmacology, Birjand University of Medical Sciences, Birjand, Iran AD - Department of Animal Sciences, Birjand University, Birjand, Iran Y1 - 2015 PY - 2015 VL - 18 IS - 6 SP - 616 EP - 622 KW - Malva sylvestris KW - Mice KW - Skin KW - Wound healing DO - 10.22038/ijbms.2015.4542 N2 - Objective(s): The aim of this study was to evaluate the effects of Malva sylvestris aqueous extract on cutaneous wound healing in BALB/c mice. Materials and Methods: Twenty seven male BALB/c mice (2.5 months of age) were used. A cut wound (superficial fascia depth) was made locally. The mice were then divided into three groups: the first, second and third groups received topical administration of M. sylvestris 1% aqueous extract,  silver sulfadiazine topical cream or  cold cream (positive and negative control groups), respectively. On days 4, 7 and 10 excisional biopsies were performed and wound healing was evaluated histopathologically. The data were analyzed by the ANOVA and Tukey statistical tests.                                               Results: On days 4 and 7, the numbers of inflammatory cells in the silver sulfadiazine and                M. sylvestris-treated groups were significantly lower than the control group and keratinization at the edges of the wound in both groups was significantly higher than the control group. On the tenth day of the study, the Malva-treated mice showed better healing features and less fibrosis and scar formation, and also fewer hair follicles were damaged in this group. On the tenth day of the study, the numbers of inflammatory cells in M. sylvestris and silver sulfadiazine-treated groups were significantly lower than the control group. Conclusion: The present study supports the beneficial effects of M. sylvestris on the wound healing process and suggests a potential clinical application. UR - https://ijbms.mums.ac.ir/article_4542.html L1 - https://ijbms.mums.ac.ir/article_4542_08ba3a43575e03b6a4b728c5b4d929ca.pdf ER -