TY - JOUR ID - 4656 TI - Effects of silymarin on neuropathic pain and formalin-induced nociception in mice JO - Iranian Journal of Basic Medical Sciences JA - IJBMS LA - en SN - 2008-3866 AU - Hassani, Faezeh Vahdati AU - Rezaee, Ramin AU - Sazegara, Hasan AU - Hashemzaei, Mahmoud AU - Shirani, Kobra AU - Karimi, Gholamreza AD - School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran AD - Department of Physiology and Pharmacology, School of Medicine, North Khorasan University of Medical Sciences, Bojnurd, Iran AD - Department of Pharmacology and Toxicology, School of Pharmacy, Zabol University of Medical Sciences, Zabol, Iran AD - Medical Toxicology Research Center and Pharmacy School, Mashhad University of Medical Sciences, Mashhad, Iran Y1 - 2015 PY - 2015 VL - 18 IS - 7 SP - 715 EP - 720 KW - Silymarin KW - Formalin test KW - Sciatic nerve ligation KW - Inflammatory pain DO - 10.22038/ijbms.2015.4656 N2 - Objective(s):Based on the previous reports, silymarin can suppress nitric oxide, prostaglandin E2 (PGE2), leukotrienes, cytokines production, and neutrophils infiltration. Regarding the fact that inflammation plays an important role in neuropathic and formalin-induced pain, it was assumed that silymarin could reduce pain. The present study investigates the analgesic effects of silymarin in chemical nociception and a model of neuropathic pain. Materials and Methods: Chemical nociception was produced by injection of 20 µl of formalin (0.5% formaldehyde in saline) into the plantar region of the right hind paw. A sciatic-nerve ligated mouse was applied as the model of neuropathic pain and the antinociceptive response of silymarin was examined 14 days after unilateral nerve-ligation using the hot plate test. Results:The intraperitoneal administration of silymarin (25, 50, and, 100 mg/kg) 2 hr prior to the intraplantar formalin injection suppressed the nociceptive response during the late phase of the formalin test significantly, but it was not in a dose-dependent manner. Different doses of silymarin 14 days after unilateral sciatic nerve ligation in hot plate test did not induce obvious antinociception. Conclusion:Results of the present study indicated that repeated administration of silymarin prevents the formalin-induced nociceptive behavior. However, it is not effective in the treatment of sciatic neuropathic pain. UR - https://ijbms.mums.ac.ir/article_4656.html L1 - https://ijbms.mums.ac.ir/article_4656_9111d2bc5b4a27bc5937fdfbaa8dd434.pdf ER -