TY - JOUR ID - 4845 TI - The POLG Gene Polymorphism in Iranian Varicocele-Associated Infertility Patients JO - Iranian Journal of Basic Medical Sciences JA - IJBMS LA - en SN - 2008-3866 AU - Heidari, Mohammad Mehdi AU - Khatami, Mehri AU - Talebi, Ali Reza AD - Department of Biology, Science School, Yazd University, Yazd, Iran AD - Department of Anatomy, Research Clinical Center for Infertility, Shahid Sadughi University of Medical Sciences, Yazd, Iran Y1 - 2012 PY - 2012 VL - 15 IS - 2 SP - 739 EP - 744 KW - CAG repeats length KW - Infertility KW - Mitochondria KW - POLG gene KW - Varicocele DO - 10.22038/ijbms.2012.4845 N2 - Objective(s) Varicocele is associated with impaired testicular function and male infertility, but the molecular mechanisms by which fertility is affected have not been satisfactorily explained. The aim of our study was to investigate whether or not the polymerase gamma (POLG) polymorphism is associated with Iranian varicocele patients.    Materials and Methods We determined the POLG CAG repeat length in DNA samples extracted from 40 varicocele patients and 30 control subjects by PCR-denature polyacrylamide gel electrophoresis and sequencing. Results The distribution of the CAG repeat length in varicocele patients showed no notable difference from that in control subjects, but we found a significant statistical inverse correlation between 10/10 and 10/#10 genotypes and varicocele grade. Conclusion These findings indicate that POLG CAG repeats may affects the varicocele grade, but the mechanisms remain to be elucidated.  UR - https://ijbms.mums.ac.ir/article_4845.html L1 - https://ijbms.mums.ac.ir/article_4845_bd44314788ec30844fa69e40242674b6.pdf ER -