TY - JOUR ID - 4972 TI - Effect of Dexamethasone on Striatal Neurotransmissions in the Rats Subjected to Parkinson’s Disease Animal Model JO - Iranian Journal of Basic Medical Sciences JA - IJBMS LA - en SN - 2008-3866 AU - Amanlou, Massoud AU - Siadat, Seyed Davar AU - Norouzian, Dariush AU - Aghasadeghi, Mohammad Reza AU - Fathi- Moghaddam, Hadi AU - Piryaei, Mohhamad AU - Shafiee Ardestani, Mehdi AD - Department of Medicinal Chemistry, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran AD - R and D and QC consultant & Hepatitis and AIDS Department, Research and Production Complex, Pasteur Institute of Iran, Tehran, Iran AD - Department of Physiology and Physiology Research Center, Jundishapour University of Medical Sciences, Ahvaz, Iran AD - Department of Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran Y1 - 2011 PY - 2011 VL - 14 IS - 2 SP - 107 EP - 115 KW - Dexamethasone KW - Dopamine KW - GABA KW - Glutamate KW - Parkinson’s disease DO - 10.22038/ijbms.2011.4972 N2 - Objective(s) The aim of this study was to evaluate the effects of dexamethasone on striatal dopaminergic, glutamatergic and gamma amino butyric acid (GABA) ergic neurotransmission in normal and parkinsonian rats. Materials and Methods Dexamethasone (0.15, 0.30, 0.60 and 0.8 mg/kg) was administered to normal or parkinsonian rats (i.p.) followed by the analysis of the striatal neurotransmitters concentrations. Additionally, the effect of dexamethasone on the damaged Substantia nigra pars compata (SNc) neurons has been investigated. Results Dexamethasone resulted in decreased level of striatum glutamatergic-GABAergic and enhanced dopaminergic neurotransmission in normal and parkinsonian rats. In addition, acute treatment with dexamethasone did not improve the lesion at all. Conclusion These findings suggest the new therapeutic mechanism of action for dexamethasone in Parkinson’s disease animal model. UR - https://ijbms.mums.ac.ir/article_4972.html L1 - https://ijbms.mums.ac.ir/article_4972_d7950b0b99d67a03051e0b76dbea0a3e.pdf ER -