TY - JOUR ID - 5037 TI - Anti-inflammatory, Antipruritic and Mast Cell Stabilizing Activity of Aristolochia Indica JO - Iranian Journal of Basic Medical Sciences JA - IJBMS LA - en SN - 2008-3866 AU - Elizabeth Mathew, Jessy AU - Keloth Kaitheri, Srinivasan AU - DinakaranVachala, Seekarajapuram AU - Jose, Magi AD - Department of Pharmaceutical Chemistry, MCOPS, Manipal University, Karnataka, India Y1 - 2011 PY - 2011 VL - 14 IS - 5 SP - 422 EP - 427 KW - Anti-inflammatory KW - Anti-antipruritic KW - Aristolochia indica KW - Mast cell stabilizing activity DO - 10.22038/ijbms.2011.5037 N2 - Objective(s) Aristolochia indica has been widely used in the traditional medicine for the treatment of a variety of diseases. In the present study different extracts of roots of A. indica were evaluated for their anti‌inflammatory, antipruritic and mast cell stabilizing activity. Materials and Methods Anti-inflammatory activity was performed by compound 48/80 induced rat paw edema model and antipruritic activity by examining the incidence of scratching behavior. Mast cell stabilizing activity was performed by compound 48/80 and sheep serum induced mast cell degranulation methods. Results The ethanol extract (300 mg/kg) and petroleum ether extract (100 mg/kg) were found to inhibit mast cell degranulation significantly equivalent to that of standard drug ketotifen (69%) by compound 48/80 model. In sheep serum model the ethanol extracts (150 and 300 mg/kg) and petroleum ether extract (100 mg/kg) showed good mast cell stabilizing activity (66-67%). Ethanol extract at 150 mg/kg showed 70% reduction of rat paw oedema and also significantly reduced the scratching response. Conclusion Results suggest A. indica has good mast cell stabilizing, anti-inflammatory and antipruritic activity. UR - https://ijbms.mums.ac.ir/article_5037.html L1 - https://ijbms.mums.ac.ir/article_5037_c8b26b912041a7eb528e8ba2e822a129.pdf ER -