TY - JOUR ID - 5469 TI - Oxidative stress, biochemical alterations, and hyperlipidemia in female rats induced by lead chronic toxicity during puberty and post puberty periods JO - Iranian Journal of Basic Medical Sciences JA - IJBMS LA - en SN - 2008-3866 AU - Alya, Annabi AU - Bini Ines, Dhouib AU - Montassar, Lasram AU - Najoua, Gharbi AU - Saloua, El Fazâa AD - Laboratory of Aggression Physiology and Endocrine Metabolic Studies, Department of Biology, Faculty of Sciences, Tunis, Tunisia Y1 - 2015 PY - 2015 VL - 18 IS - 10 SP - 1034 EP - 1043 KW - Female KW - Hepatotoxicity Hyperlipidemia KW - Lead KW - Nephrotoxicity KW - Rat DO - 10.22038/ijbms.2015.5469 N2 - Objective(s):Lead (Pb) is a toxic metal inducing many destructive effects leading to a broad range of physiological, biochemical, and neurological dysfunctions in humans and laboratory animals. Materials and Methods: Here, we investigated the effect of chronic exposure to Pb (50 mg/l) on oxidative stress, hepatotoxicity, nephrotoxicity, and lipid profile of two different age groups of female rats treated with Pb from delivery until puberty period (40 days, Pb40) and post puberty period (65 days, Pb65). Results: Our results clearly show that the administration of Pb produces oxidative damage in liver and kidney, as strongly suggested by the significant increase in TBARS, decrease in total SH, and the alteration of SOD activity. Elevation in liver function biomarkers, alanine aminotransferase (ALT) and aspartate aminotransferase (AST) and reduction in total protein (liver and plasma) and albumin are evidence of perturbations of liver synthetic function. In young Pb-treated group, Pb-induced nephropathy was more pronounced by the increase in the levels of creatinine, urea, and uric acid. However, hyperlipidemia was evident for both Pb-exposed groups leading to a potential risk for cardiovascular diseases and atherosclerosis. Conclusion: It is concluded that Pb induces metabolic and oxidative disturbances depending on the age of the animals, which are not negligible. UR - https://ijbms.mums.ac.ir/article_5469.html L1 - https://ijbms.mums.ac.ir/article_5469_3575b8cc804f908d3ff797d7f0eef852.pdf ER -