TY - JOUR ID - 6809 TI - Expression of the Mir-133 and Bcl-2 could be affected by swimming training in the heart of ovariectomized rats JO - Iranian Journal of Basic Medical Sciences JA - IJBMS LA - en SN - 2008-3866 AU - Habibi, Parisa AU - Alihemmati, Alireza AU - NourAzar, Alireza AU - Yousefi, Hadi AU - Mortazavi, Safieh AU - Ahmadiasl, Nasser AD - Department of Physiology, Tabriz University of Medical Sciences, Tabriz, Iran AD - Department of Histology & Embryology, Tabriz University of Medical Sciences, Tabriz, Iran AD - Department of Physiology, Tabriz Branch, Islamic Azad University, Tabriz, Iran AD - Tabriz University of Medical Sciences, Tabriz, Iran AD - Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran Y1 - 2016 PY - 2016 VL - 19 IS - 4 SP - 381 EP - 387 KW - Bcl-2 KW - Heart KW - Mir-133 KW - Ovariectomy KW - Swimming training DO - 10.22038/ijbms.2016.6809 N2 - Objective(s): The beneficial and more potent role of exercise to prevent heart apoptosis in ovariectomized rats has been known. The aim of this study was to examine the effects of swimming training on cardiac expression of Bcl-2, and Mir-133 levels and glycogen changes in the myocyte. Materials and Methods: Forty animals were separated into four groups as control, sham, ovariectomy (OVX) and ovariectomized group with 8 weeks swimming training (OVX.E). Training effects were evaluated by measuring lipid profiles, Bcl-2 and Mir-133 expression levels in the cardiac tissue. Grafts were analyzed by reverse transcription–polymerase chain reaction for Bcl-2 mRNA and Mir-133 and by Western blot for Bcl-2 protein. Results: Ovariectomy down-regulated Bcl-2 and Mir-133 expression levels in the cardiac tissue, and swimming training up-regulated their expression significantly (P<0.05). Conclusion: Our results showed that regular exercise as a physical replacement therapy could prevent and improve the effects of estrogen deficiency in the cardia. UR - https://ijbms.mums.ac.ir/article_6809.html L1 - https://ijbms.mums.ac.ir/article_6809_463b75af1b792a62a9a4ec9ad0292070.pdf ER -