TY - JOUR ID - 7602 TI - Prednison provokes serum and vasoactive substances in a mice model of immune thrombocytopenia JO - Iranian Journal of Basic Medical Sciences JA - IJBMS LA - en SN - 2008-3866 AU - Zhang, Ling AU - Chen, Ke AU - Li, Tiantian AU - He, Hao AU - Hou, Li AU - Wu, Xiaoyong AU - Sun, Yanping AU - Zheng, Lei AU - Chen, Zhixiong AU - Qin, Bei AU - Chen, Xinyi AU - Tian, Shaodan AD - Dongzhimen Hosp. Beijing University of Chinese Medicine. No. 5 Haiyuncang, Dongcheng District, Beijing, China AD - School of Pharmacy, Xi’an Medical College, Shanxi 710021, China AD - No. 1 Hospital Affiliated to Guiyang College of TCM, GuiYang 550001, China AD - No. 1 Hospital Affiliated to Guangzhou University of Chinese Medicine, Guangzhou 510405, China Y1 - 2016 PY - 2016 VL - 19 IS - 9 SP - 1010 EP - 1015 KW - Immune thrombocytopenia KW - Mice KW - Norepinephrine VIP KW - β-EP KW - 5-HT DO - 10.22038/ijbms.2016.7602 N2 - Objective(s): The main objective of this study was to investigate the variations of β-endorphin (β-EP), vasoactive intestinal peptide (VIP), serotonin (5-HT) and norepinephrine (NE) of immune thrombocytopenia (ITP) mice as well as the regulatory mechanism of prednison. Materials and Methods: Sixty BALB/c mice were randomly divided into control group, model group and prednison intervention group. ITP mice model was duplicated by injecting with glycoprotein-antiplatelet serum (GP-APS) except in control group. After ITP disease model was successful established, prednison was used in prednison intervention group. The β-EP, VIP, 5-HT and NE contents of ITP mice were detected by enzyme linked immunosorbent assay (ELISA). Results:Compared with the values in control group, the detection values of VIP and 5-HT in model group declined, while the detection values of β-EP and NE increased. Compared with prednison intervention group, the detection values of VIP and 5-HT in model group increased, while the detection values of β-EP and NE showed no significant change. Conclusion: In this study, the β-EP, VIP, 5-HT and NE contents in ITP mice injected with GP-APS were changed by prednison. It shows that prednison as the first-line therapy for ITP with effective hemostasis function is likely to increasing the contents of VIP and 5-HT. These results suggest the therapeutic value of prednison for the treatment of ITP. UR - https://ijbms.mums.ac.ir/article_7602.html L1 - https://ijbms.mums.ac.ir/article_7602_fbe8c0a4eab88ae50f406bf77aa7f249.pdf ER -