TY - JOUR ID - 8842 TI - Mori cortex prevents kidney damage through inhibiting expression of inflammatory factors in the glomerulus in streptozocin-induced diabetic rats JO - Iranian Journal of Basic Medical Sciences JA - IJBMS LA - en SN - 2008-3866 AU - Ma, Lili AU - Ni, Hailai AU - Zou, Xinrong AU - Yuan, Yanyan AU - Luo, Chun AU - Liu, Bingyang AU - Wang, Fuyan AU - Xi, Yang AU - Chu, Yudong AU - Xu, Pangjie AU - Qiu, Xiaohui AU - Li, Song AU - Bu, Shizhong AD - Runliang Diabetes Laboratory, Diabetes Research Center, Ningbo University. Ningbo, Zhejiang, PR China AD - Department of Prevention and Health, Changhai Hospital, Second Military Medical University, Shanghai, PR China AD - Department of Nephrology, Ningbo Medical Center Lihuili Eastern Hospital, Ningbo, Zhejiang, PR China AD - Center for Pharmacogenetics, University of Pittsburgh School of Pharmacy, Pittsburgh, PA 15261, USA Y1 - 2017 PY - 2017 VL - 20 IS - 6 SP - 715 EP - 721 KW - Diabetic nephropathy KW - Herb KW - Inflammation KW - Renal injury DO - 10.22038/ijbms.2017.8842 N2 - Objective(s): It has been widely reported that Mori cortex extract (MCE) is used for the treatment of diabetes mellitus in traditional medicine. The present study was designed to investigate its mechanism of action in the treatment of diabetic nephropathy (DN). We assessed whether MCE preventive treatment ameliorates kidney damage in high-fat diet and streptozotocin (STZ)-induced type 2 diabetic rats. Materials and Methods: Rats were fed a high-fat diet and injected with STZ. MCE was given to rats daily at 10 g/kg. Fasting blood glucose (FBG) and postprandial plasma glucose were measured. Blood and urine biochemical parameters, renal tissue morphology, and inflammation were investigated. Results: Prevention with MCE significantly decreased FBG and homoeostasis model assessment (HOMA) of IR (HOMA-IR) levels and increased insulin levels in diabetic rats. MCE prevention significantly decreased levels of KW/BW, BUN, Cr, and 24 hr urinary protein. MCE inhibited glomerular basement membrane thickening, tubular epithelial cell hypertrophy, and glomerular capillary dilation. MCE also prevented the disappearance of bowman’s space and renal tubular lumen and decreased collagen deposition in rat kidney. Moreover, MCE reduced the levels of inflammatory factors (MCP-1 and TNF-α) and fibrosis factors (collagen IV and fibronectin). Conclusion: MCE prevents DN through inhibition of inflammation and fibrosis in a rat model. It might provide a safe and effective way to prevent DN. UR - https://ijbms.mums.ac.ir/article_8842.html L1 - https://ijbms.mums.ac.ir/article_8842_164e17138a1ad27d8525f453660513d9.pdf ER -