<?xml version="1.0" encoding="utf-8"?>
			<journal>
			<title>Iranian Journal of Basic Medical Sciences</title>
			<title_fa></title_fa>
			<short_title></short_title>
			<subject>Medical Sciences</subject>
			<web_url>https://ijbms.mums.ac.ir/</web_url>
			<journal_hbi_system_id>0</journal_hbi_system_id>
			<journal_hbi_system_user></journal_hbi_system_user>
			<journal_id_issn>2008-3866</journal_id_issn>
			<journal_id_issn_online>2008-3874</journal_id_issn_online>
			<journal_id_pii></journal_id_pii>
			<journal_id_doi></journal_id_doi>
			<journal_id_iranmedex></journal_id_iranmedex>
			<journal_id_magiran></journal_id_magiran>
			<journal_id_sid></journal_id_sid>
			<journal_id_nlai></journal_id_nlai>
			<journal_id_science></journal_id_science>
			<language>en</language>
			<pubdate>
				<type>jalali</type>
				<year>0</year>
				<month>0</month>
				<day>1</day>
			</pubdate>
			<pubdate>
				<type>gregorian</type>
				<year>2018</year>
				<month>2</month>
				<day>1</day>
			</pubdate>
			<volume>21</volume>
			<number>2</number>
			<publish_type>online</publish_type>
			<publish_edition>1</publish_edition>
			<article_type>fulltext</article_type>
			<articleset><article>
				<language>en</language>
				<article_id_issn></article_id_issn>
				<article_id_issn_online></article_id_issn_online>
				<article_id_pubmed></article_id_pubmed>
				<article_id_pii></article_id_pii>
				<article_id_doi></article_id_doi>
				<article_id_iranmedex></article_id_iranmedex>
				<article_id_magiran></article_id_magiran>
				<article_id_sid></article_id_sid>
				<title_fa></title_fa>
				<title>Hypericin-photodynamic therapy inhibits proliferation and induces apoptosis in human rheumatoid arthritis fibroblast-like synoviocytes cell line MH7A</title>
				<subject_fa></subject_fa>
				<subject></subject>
				<content_type_fa></content_type_fa>
				<content_type>Original Article</content_type>
				<abstract_fa><![CDATA[]]></abstract_fa>
				<abstract><![CDATA[Objective(s): To elucidate the effects and potential mechanisms of hypericin-photodynamic therapy (HYP-PDT) for treating the human rheumatoid arthritis (RA) fibroblast-like synoviocyte (FLS) MH7A cell-line. Materials and Methods: MH7A cells were subjected to HYP-PDT intervention and apoptosis was evaluated via MTT, nuclear staining, and flowcytometry analyses. Intracellular reactive oxygen species (ROS) were measured with the fluorescent probe 2’7’-dichlorofluorescein diacetate (DCFH-DA). To verify the effects of HYP on apoptotic and nuclear factor kappa-B (NF-κB) pathways, caspase-8, 9, poly-ADP-ribose polymerase (PARP), phosphorylated (p)-NF-κB p65, NF-κB p65 and p-IκBα protein expressions were quantified with western blot. Quantitative real-time PCR was used to assay NF-κB p65 mRNA. Results: HYP-PDT inhibited MH7A cell viability and induced apoptosis in a dose-dependent manner. Meanwhile, intracellular ROS levels increased significantly after HYP-PDT treatment. Furthermore, the expression of cleaved caspase-9 and PARP was increased by HYP-PDT treatment, with a concurrent decline in NF-κB. Conclusion: HYP-PDT induces apoptosis in MH7A cells, at least partially, via generation of ROS, regulation of the apoptotic pathway and suppression of the NF-κB pathway. These findings suggest that HYP-PDT may be a potential treatment for RA.]]></abstract>
				<keyword_fa></keyword_fa>
				<keyword>Apoptosis Fibroblast-like synoviocyte Hypericin-photodynamic, –therapy Nuclear factor kappa-B Rheumatoid arthritis Reactive oxygen species</keyword>
				<start_page>130</start_page>
				<end_page>137</end_page>
				<web_url>https://ijbms.mums.ac.ir/article_10064.html</web_url>
			<author_list><author>
				<first_name>Kun</first_name>
				<middle_name></middle_name>
				<last_name>Zhang</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>zhangkun0415@163.com</email>
				<code>41801</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Orthopedics, No. 91 Central hospital of Liberation Army, Jiaozuo 454150, Henan province, China</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Shan</first_name>
				<middle_name></middle_name>
				<last_name>Gao</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>18560936480@163.com</email>
				<code>41802</code>
				<coreauthor>No</coreauthor>
				<affiliation>Faculty of Graduate Studies, Hunan University of Chinese Medicine, Changsha 410208, Hunan Province, China</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Jiayi</first_name>
				<middle_name></middle_name>
				<last_name>Guo</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>13014735898@163.com</email>
				<code>41803</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Orthopedics, Luoyang Orthopedic Hospital of Henan Province, Luoyang 471000, Henan Province, China</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Guohua</first_name>
				<middle_name></middle_name>
				<last_name>Ni</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>463103027@qq.com</email>
				<code>41804</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Orthopedics, No. 91 Central hospital of Liberation Army, Jiaozuo 454150, Henan province, China</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Zhe</first_name>
				<middle_name></middle_name>
				<last_name>Chen</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>1024221847@qq.com</email>
				<code>41805</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Orthopedics, Luoyang Orthopedic Hospital of Henan Province, Luoyang 471000, Henan Province, China</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Feng</first_name>
				<middle_name></middle_name>
				<last_name>Li</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>404920698@qq.com</email>
				<code>41806</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Orthopedics, Luoyang Orthopedic Hospital of Henan Province, Luoyang 471000, Henan Province, China</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Xiaolei</first_name>
				<middle_name></middle_name>
				<last_name>Zhu</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>weikuo1988@163.com</email>
				<code>41807</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Orthopedics, Luoyang Orthopedic Hospital of Henan Province, Luoyang 471000, Henan Province, China</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Yongbing</first_name>
				<middle_name></middle_name>
				<last_name>Wen</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>506589222@qq.com</email>
				<code>41808</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Orthopedics, Luoyang Orthopedic Hospital of Henan Province, Luoyang 471000, Henan Province, China</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Yanxing</first_name>
				<middle_name></middle_name>
				<last_name>Guo</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>18553354680@163.com</email>
				<code>41809</code>
				<coreauthor>Yes</coreauthor>
				<affiliation>Department of Orthopedics, Luoyang Orthopedic Hospital of Henan Province, Luoyang 471000, Henan Province, China</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author></author_list>
				</article>
			</articleset>
			</journal>