<?xml version="1.0" encoding="utf-8"?>
			<journal>
			<title>Iranian Journal of Basic Medical Sciences</title>
			<title_fa></title_fa>
			<short_title></short_title>
			<subject>Medical Sciences</subject>
			<web_url>https://ijbms.mums.ac.ir/</web_url>
			<journal_hbi_system_id>0</journal_hbi_system_id>
			<journal_hbi_system_user></journal_hbi_system_user>
			<journal_id_issn>2008-3866</journal_id_issn>
			<journal_id_issn_online>2008-3874</journal_id_issn_online>
			<journal_id_pii></journal_id_pii>
			<journal_id_doi></journal_id_doi>
			<journal_id_iranmedex></journal_id_iranmedex>
			<journal_id_magiran></journal_id_magiran>
			<journal_id_sid></journal_id_sid>
			<journal_id_nlai></journal_id_nlai>
			<journal_id_science></journal_id_science>
			<language>en</language>
			<pubdate>
				<type>jalali</type>
				<year>0</year>
				<month>0</month>
				<day>1</day>
			</pubdate>
			<pubdate>
				<type>gregorian</type>
				<year>2018</year>
				<month>8</month>
				<day>1</day>
			</pubdate>
			<volume>21</volume>
			<number>8</number>
			<publish_type>online</publish_type>
			<publish_edition>1</publish_edition>
			<article_type>fulltext</article_type>
			<articleset><article>
				<language>en</language>
				<article_id_issn></article_id_issn>
				<article_id_issn_online></article_id_issn_online>
				<article_id_pubmed></article_id_pubmed>
				<article_id_pii></article_id_pii>
				<article_id_doi></article_id_doi>
				<article_id_iranmedex></article_id_iranmedex>
				<article_id_magiran></article_id_magiran>
				<article_id_sid></article_id_sid>
				<title_fa></title_fa>
				<title>Di-(2-ethylhexyl) phthalate induces precocious puberty in adolescent female rats</title>
				<subject_fa></subject_fa>
				<subject></subject>
				<content_type_fa></content_type_fa>
				<content_type>Original Article</content_type>
				<abstract_fa><![CDATA[]]></abstract_fa>
				<abstract><![CDATA[Objective(s): Nowadays, Di-(2-ethylhexyl) phthalate (DEHP) is widely used in different kinds of commercial products as a plasticizer. Previous studies have revealed that exposures to DEHP could be associated with precocious puberty in teenagers, but the exact mechanism is yet to be known. Materials and Methods: In this study, 48 prepubertal Wistar female rats were randomly apportioned into 4 groups and orally treated with 0, 250, 500, and 1000 mg/kg/d DEHP from postnatal day 21 up to 4 weeks. Subsequently, we examined the indicators related to the initiation of sexual development. Results: DEHP was able to shorten the vaginal opening time and prolong the estrous cycles of female rats. IGF-1 expression was significantly upregulated by 1000 mg/kg/d DEHP in the hypothalamus, and the hypothalamic, as well as serum levels of GH, were also upregulated by DEHP. It also caused decrements in serum levels of FSH, LH, and T and the increment in level of progesterone. Meanwhile, DEHP was able to exert its effect on the mRNA and protein expression levels of Kiss-1, GPR54, and GnRH in the hypothalamus in pubertal female rats. Conclusion: These findings are revealing that DEHP exposure more likely causes imbalances of hypothalamus functioning in pubertal female rats and thus induces precautious puberty in these animals.]]></abstract>
				<keyword_fa></keyword_fa>
				<keyword>Di-(2-ethylhexyl) phthalate, Female, Hypothalamus, Precocious puberty, Reproductive</keyword>
				<start_page>848</start_page>
				<end_page>855</end_page>
				<web_url>https://ijbms.mums.ac.ir/article_11026.html</web_url>
			<author_list><author>
				<first_name>Te</first_name>
				<middle_name></middle_name>
				<last_name>Liu</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>494376053@qq.com</email>
				<code>46121</code>
				<coreauthor>No</coreauthor>
				<affiliation>Scientific Research Center, China-Japan Union Hospital of Jilin University, Changchun, 130033, China</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Yuzhuo</first_name>
				<middle_name></middle_name>
				<last_name>Wang</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>1635911970@qq.com</email>
				<code>46122</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Orthodontics, School and Hospital of Stomatology, Jilin University, Changchun, 130021, China</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Modi</first_name>
				<middle_name></middle_name>
				<last_name>Yang</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>yangmodi0513@163.com</email>
				<code>46123</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Orthopedics, China-Japan Union Hospital of Jilin University, Changchun 130033, China</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Pu</first_name>
				<middle_name></middle_name>
				<last_name>Shao</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>281496665@qq.com</email>
				<code>46124</code>
				<coreauthor>No</coreauthor>
				<affiliation>Scientific Research Center, China-Japan Union Hospital of Jilin University, Changchun, 130033, China</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Lian</first_name>
				<middle_name></middle_name>
				<last_name>Duan</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>387868845@qq.com</email>
				<code>46125</code>
				<coreauthor>No</coreauthor>
				<affiliation>Scientific Research Center, China-Japan Union Hospital of Jilin University, Changchun, China.</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Meng</first_name>
				<middle_name></middle_name>
				<last_name>Li</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>928871626@q.com</email>
				<code>46126</code>
				<coreauthor>No</coreauthor>
				<affiliation>Scientific Research Center, China-Japan Union Hospital of Jilin University, Changchun, 130033, China</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Mingji</first_name>
				<middle_name></middle_name>
				<last_name>Zhu</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>zhumingji33@163.com</email>
				<code>46127</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Dermatological, China-Japan Union Hospital of Jilin University, Changchun, 130033, China</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Jie</first_name>
				<middle_name></middle_name>
				<last_name>Yang</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>iamliute@126.com</email>
				<code>46128</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Endocrinology, China-Japan Union Hospital of Jilin University, Changchun, 130033, China</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Jinlan</first_name>
				<middle_name></middle_name>
				<last_name>Jiang</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>iamliute@hotmail.com</email>
				<code>46129</code>
				<coreauthor>Yes</coreauthor>
				<affiliation>Scientific Research Center, China-Japan Union Hospital of Jilin University, Changchun, 130033, China</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author></author_list>
				</article>
			</articleset>
			</journal>