<?xml version="1.0" encoding="utf-8"?>
			<journal>
			<title>Iranian Journal of Basic Medical Sciences</title>
			<title_fa></title_fa>
			<short_title></short_title>
			<subject>Medical Sciences</subject>
			<web_url>https://ijbms.mums.ac.ir/</web_url>
			<journal_hbi_system_id>0</journal_hbi_system_id>
			<journal_hbi_system_user></journal_hbi_system_user>
			<journal_id_issn>2008-3866</journal_id_issn>
			<journal_id_issn_online>2008-3874</journal_id_issn_online>
			<journal_id_pii></journal_id_pii>
			<journal_id_doi></journal_id_doi>
			<journal_id_iranmedex></journal_id_iranmedex>
			<journal_id_magiran></journal_id_magiran>
			<journal_id_sid></journal_id_sid>
			<journal_id_nlai></journal_id_nlai>
			<journal_id_science></journal_id_science>
			<language>en</language>
			<pubdate>
				<type>jalali</type>
				<year>0</year>
				<month>0</month>
				<day>1</day>
			</pubdate>
			<pubdate>
				<type>gregorian</type>
				<year>2019</year>
				<month>7</month>
				<day>1</day>
			</pubdate>
			<volume>22</volume>
			<number>7</number>
			<publish_type>online</publish_type>
			<publish_edition>1</publish_edition>
			<article_type>fulltext</article_type>
			<articleset><article>
				<language>en</language>
				<article_id_issn></article_id_issn>
				<article_id_issn_online></article_id_issn_online>
				<article_id_pubmed></article_id_pubmed>
				<article_id_pii></article_id_pii>
				<article_id_doi></article_id_doi>
				<article_id_iranmedex></article_id_iranmedex>
				<article_id_magiran></article_id_magiran>
				<article_id_sid></article_id_sid>
				<title_fa></title_fa>
				<title>Irisin protect the Dopaminergic neurons of the Substantia nigra in the rat model of Parkinson’s disease</title>
				<subject_fa></subject_fa>
				<subject></subject>
				<content_type_fa></content_type_fa>
				<content_type>Original Article</content_type>
				<abstract_fa><![CDATA[]]></abstract_fa>
				<abstract><![CDATA[Objective(s): Exercise ameliorates the quality of life and reduces the risk of neurological derangements such as Alzheimer’s (AD) and Parkinson’s disease (PD). Irisin is a product of the physical activity and is a circulating hormone that regulates the energy metabolism in the body. In the nervous system, Irisin influences neurogenesis and neural differentiation in mice. We previously demonstrated that co-treatment of bone marrow stem cells (BMSCs) with a neurotrophic factor reduce Parkinson’s symptoms. Our goal in this project was to evaluate whether Irisin with BMSCs can protect the dopaminergic (DA) neurons in PD. Materials and Methods: 35 adult male Wistar rat weighing (200-250 g) were chosen. They were separated into five experimental groups (n=7). To create a Parkinson’s model, intranasal (IN) administration of the MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) was used. The BMSCs (2×106) and Irisin (50 nm/ml) was used for 7 days for treatment after creation of the PD model. After completion of the tests (4 weeks), their brains were used for the TUNEL and immunohistochemical (IHC) assays.Results: One of the important results of this study was that the Irisin induce BMSCs transport into the injured area of the brain. Co-treatment of the Irisin with BMSCs increased tyrosine hydroxylase-positive neurons (TH+) in substantia nigra (SN) and striatum of the PD mice brain. In this group, the number of TUNEL-positive cells significantly decreased. Behavioral symptoms were better in the combination group and Irisin simultaneously. Conclusion: Co- treatment of Irisin with BMSCs protects the DA neurons from degeneration and apoptotic process after MPTP injection.]]></abstract>
				<keyword_fa></keyword_fa>
				<keyword>Irisin, Mesenchymal stem cells, Parkinson’s disease, Substantia nigra, Tunel</keyword>
				<start_page>722</start_page>
				<end_page>728</end_page>
				<web_url>https://ijbms.mums.ac.ir/article_13161.html</web_url>
			<author_list><author>
				<first_name>Sam</first_name>
				<middle_name></middle_name>
				<last_name>Zarbakhsh</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>szarbakhsh@yahoo.com</email>
				<code>55970</code>
				<coreauthor>No</coreauthor>
				<affiliation>Research Center of Nervous System Stem Cells, Department of Anatomy, Semnan University of Medical Sciences, Semnan , Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Manouchehr</first_name>
				<middle_name></middle_name>
				<last_name>Safari</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>kh_safari@yahoo.com</email>
				<code>55969</code>
				<coreauthor>Yes</coreauthor>
				<affiliation>Research Center of Nervous System Stem Cells, Department of Anatomy, Semnan University of Medical Sciences, Semnan , Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Mohammad Reza</first_name>
				<middle_name></middle_name>
				<last_name>Aldaghi</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>mald222@yahoo.com</email>
				<code>55975</code>
				<coreauthor>No</coreauthor>
				<affiliation>Research Center of Nervous System Stem Cells, Department of Anatomy, Semnan University of Medical Sciences, Semnan , Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Hamidreza</first_name>
				<middle_name></middle_name>
				<last_name>Sameni</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>hrsameni@gmail.com</email>
				<code>55972</code>
				<coreauthor>No</coreauthor>
				<affiliation>Research Center of Nervous System Stem Cells, Department of Anatomy, Semnan University of Medical Sciences, Semnan , Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Laya</first_name>
				<middle_name></middle_name>
				<last_name>Ghahari</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>laya_gh@yahoo.com</email>
				<code>55971</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Anatomy, AJA University of Medical Sciences, Tehran, Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Younes</first_name>
				<middle_name></middle_name>
				<last_name>Khaleghi Lagmouj</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>ykhaleghi@gmail.com</email>
				<code>55973</code>
				<coreauthor>No</coreauthor>
				<affiliation>Research Center of Nervous System Stem Cells, Department of Anatomy, Semnan University of Medical Sciences, Semnan , Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Khojasteh</first_name>
				<middle_name></middle_name>
				<last_name>Rahimi Jaberi</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>khojasterahimi@gmail.com</email>
				<code>55974</code>
				<coreauthor>No</coreauthor>
				<affiliation>Research Center of Nervous System Stem Cells, Department of Anatomy, Semnan University of Medical Sciences, Semnan , Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Houman</first_name>
				<middle_name></middle_name>
				<last_name>Parsaie</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>houman70parsaie@gmail.com</email>
				<code>55976</code>
				<coreauthor>No</coreauthor>
				<affiliation>Research Center of Nervous System Stem Cells, Department of Anatomy, Semnan University of Medical Sciences, Semnan , Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author></author_list>
				</article>
			</articleset>
			</journal>