<?xml version="1.0" encoding="utf-8"?>
			<journal>
			<title>Iranian Journal of Basic Medical Sciences</title>
			<title_fa></title_fa>
			<short_title></short_title>
			<subject>Medical Sciences</subject>
			<web_url>https://ijbms.mums.ac.ir/</web_url>
			<journal_hbi_system_id>0</journal_hbi_system_id>
			<journal_hbi_system_user></journal_hbi_system_user>
			<journal_id_issn>2008-3866</journal_id_issn>
			<journal_id_issn_online>2008-3874</journal_id_issn_online>
			<journal_id_pii></journal_id_pii>
			<journal_id_doi></journal_id_doi>
			<journal_id_iranmedex></journal_id_iranmedex>
			<journal_id_magiran></journal_id_magiran>
			<journal_id_sid></journal_id_sid>
			<journal_id_nlai></journal_id_nlai>
			<journal_id_science></journal_id_science>
			<language>en</language>
			<pubdate>
				<type>jalali</type>
				<year>0</year>
				<month>0</month>
				<day>1</day>
			</pubdate>
			<pubdate>
				<type>gregorian</type>
				<year>2019</year>
				<month>9</month>
				<day>1</day>
			</pubdate>
			<volume>22</volume>
			<number>9</number>
			<publish_type>online</publish_type>
			<publish_edition>1</publish_edition>
			<article_type>fulltext</article_type>
			<articleset><article>
				<language>en</language>
				<article_id_issn></article_id_issn>
				<article_id_issn_online></article_id_issn_online>
				<article_id_pubmed></article_id_pubmed>
				<article_id_pii></article_id_pii>
				<article_id_doi></article_id_doi>
				<article_id_iranmedex></article_id_iranmedex>
				<article_id_magiran></article_id_magiran>
				<article_id_sid></article_id_sid>
				<title_fa></title_fa>
				<title>Kidney therapeutic potential of peptides derived from the bromelain hydrolysis of green peas protein</title>
				<subject_fa></subject_fa>
				<subject></subject>
				<content_type_fa></content_type_fa>
				<content_type>Original Article</content_type>
				<abstract_fa><![CDATA[]]></abstract_fa>
				<abstract><![CDATA[Objective(s): Kidney disease is a global health problem that needs a solution to its therapy. In the previous study, we found that protein hydrolysate of green peas origin of Indonesia hydrolysed by bromelain (PHGPB) showed improve kidney function in cisplatin-induced nephropathy rats. In this study, we investigated the effect of PHGPB to obtain effective dose that exerts a therapeutic effect on chronic kidney disease (CKD) based on reducing urea and creatinine levels and to elucidate its mechanism of action. Materials and Methods: Two sets of experiments were conducted: (1) characteristics and  proteomic profile of PHGPB, (2) in vivo test of PHGPB in gentamycin-induced Wistar rats, including urea and creatinine measurements, activities of antioxidant and kidney-related peptides (ANP, COX-1, and renin).Results: PHGPB showed three bands under 10 kDa using sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) and contained 10 identified proteins using liquid chromatography-tandem mass spectrometry (LC-MS/MS). Significant differences in urea and creatinine levels were found between all PHGPB treatments and positive controls (P&lt;0.01). The lowest levels of urea and creatinine that were validated by high super oxide dismutase (SOD) activity and atrial natriuretic peptide (ANP) level were obtained in the 200 mg/day PHGPB treatment. However, the mean renin level was high and cyclooxygenase-1 (COX-1) level did not exceed positive and negative control levels. Conclusion: PHGPB at dose 200 mg/kgBW shows a potential CKD therapeutic effect that is dose-dependent. Higher PHGPB dose corresponds to better effect on kidney function by increasing antioxidant activity and ANP levels in gentamycin-induced Wistar rats.]]></abstract>
				<keyword_fa></keyword_fa>
				<keyword>ANP, Bromelain, COX-1, Protein hydrolysate green pea, Renal function, Renin, SOD</keyword>
				<start_page>1016</start_page>
				<end_page>1025</end_page>
				<web_url>https://ijbms.mums.ac.ir/article_13548.html</web_url>
			<author_list><author>
				<first_name>Meilinah</first_name>
				<middle_name></middle_name>
				<last_name>Hidayat</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>mellahidayat@yahoo.com</email>
				<code>57797</code>
				<coreauthor>Yes</coreauthor>
				<affiliation>Faculty of Medicine, Universitas Kristen Maranatha, Bandung Indonesia</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Sijani</first_name>
				<middle_name></middle_name>
				<last_name>Prahastuti</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>sijaniprahastuti@yahoo.com</email>
				<code>57798</code>
				<coreauthor>No</coreauthor>
				<affiliation>Faculty of Medicine, Universitas Kristen Maranatha, Bandung Indonesia</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Destiya</first_name>
				<middle_name></middle_name>
				<last_name>Riyani</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>destiyaur@gmail.com</email>
				<code>57799</code>
				<coreauthor>No</coreauthor>
				<affiliation>Faculty of Medicine, Universitas Kristen Maranatha, Bandung Indonesia</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Andreanus</first_name>
				<middle_name></middle_name>
				<last_name>Soemardji</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>andre@fa.itb.ac.id</email>
				<code>57800</code>
				<coreauthor>No</coreauthor>
				<affiliation>School of Pharmacy, Institute Teknologi Bandung Indonesia</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Nova</first_name>
				<middle_name></middle_name>
				<last_name>Suliska</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>novasuliska@fa.itb.ac.id</email>
				<code>57801</code>
				<coreauthor>No</coreauthor>
				<affiliation>School of Pharmacy, Institute Teknologi Bandung Indonesia</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Afrilia</first_name>
				<middle_name></middle_name>
				<last_name>Garmana</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>afrilia@fa.itb.ac.id</email>
				<code>57802</code>
				<coreauthor>No</coreauthor>
				<affiliation>School of Pharmacy, Institute Teknologi Bandung Indonesia</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Bobby</first_name>
				<middle_name></middle_name>
				<last_name>Assiddiq</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>bobby@alphasains.com</email>
				<code>57803</code>
				<coreauthor>No</coreauthor>
				<affiliation>Alphasains Centre, Serpong Indonesia</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Khomaini</first_name>
				<middle_name></middle_name>
				<last_name>Hassan</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>lesanrego@gmail.com</email>
				<code>57804</code>
				<coreauthor>No</coreauthor>
				<affiliation>Faculty of Medicine, Universitas Jenderal Achmad Yani, Bandung Indonesia</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author></author_list>
				</article>
			</articleset>
			</journal>