<?xml version="1.0" encoding="utf-8"?>
			<journal>
			<title>Iranian Journal of Basic Medical Sciences</title>
			<title_fa></title_fa>
			<short_title></short_title>
			<subject>Medical Sciences</subject>
			<web_url>https://ijbms.mums.ac.ir/</web_url>
			<journal_hbi_system_id>0</journal_hbi_system_id>
			<journal_hbi_system_user></journal_hbi_system_user>
			<journal_id_issn>2008-3866</journal_id_issn>
			<journal_id_issn_online>2008-3874</journal_id_issn_online>
			<journal_id_pii></journal_id_pii>
			<journal_id_doi></journal_id_doi>
			<journal_id_iranmedex></journal_id_iranmedex>
			<journal_id_magiran></journal_id_magiran>
			<journal_id_sid></journal_id_sid>
			<journal_id_nlai></journal_id_nlai>
			<journal_id_science></journal_id_science>
			<language>en</language>
			<pubdate>
				<type>jalali</type>
				<year>0</year>
				<month>0</month>
				<day>1</day>
			</pubdate>
			<pubdate>
				<type>gregorian</type>
				<year>2021</year>
				<month>5</month>
				<day>1</day>
			</pubdate>
			<volume>24</volume>
			<number>5</number>
			<publish_type>online</publish_type>
			<publish_edition>1</publish_edition>
			<article_type>fulltext</article_type>
			<articleset><article>
				<language>en</language>
				<article_id_issn></article_id_issn>
				<article_id_issn_online></article_id_issn_online>
				<article_id_pubmed></article_id_pubmed>
				<article_id_pii></article_id_pii>
				<article_id_doi></article_id_doi>
				<article_id_iranmedex></article_id_iranmedex>
				<article_id_magiran></article_id_magiran>
				<article_id_sid></article_id_sid>
				<title_fa></title_fa>
				<title>Effects of the diphenylheptane extract of Alpinia officinarum rhizomes on ethanol-induced gastric ulcers in mice</title>
				<subject_fa></subject_fa>
				<subject></subject>
				<content_type_fa></content_type_fa>
				<content_type>Original Article</content_type>
				<abstract_fa><![CDATA[]]></abstract_fa>
				<abstract><![CDATA[Objective(s): Experimental studies have revealed that Alpinia officinarum Hance (Zingiberaceae) exhibits a gastrointestinal protective effect. The present study aimed to investigate the effects of diphenylheptanes (DPHs) extracted from A. officinarum rhizomes on ethanol-induced gastric ulcers in BALB/c mice.Materials and Methods: A total of 60 female BALB/c mice were divided into six groups as follows: negative control, which received sodium carboxymethyl cellulose; positive control, which received ethanol; treatment control, which received ethanol+ranitidine; ethanol+high dose of DPHs; ethanol+medium dose of DPHs; ethanol+low dose of DPHs. Different doses of DPHs were administered orally once daily for seven consecutive days before the animals were subjected to ethanol-induced gastric ulcers.Results: Various doses of DPHs significantly reduced Gastric ulcers index when compared with the positive control. DPHs treatments and treatment control increased the activity of superoxide dismutase; decreased the levels of inflammatory mediators, malondialdehyde, motilin, and gastrin; decreased the activity of inducible nitric oxide synthase and cyclooxygenase-2; and inhibited the expression of Toll-like receptor 4, myeloid differentiation factor 88, and nuclear factor-κB at the protein and mRNA levels. In addition, DPHs inhibited the expression of transient receptor potential vanilloid 1, calcitonin gene-related peptide, and increased the expression of substance P at the protein and mRNA levels. Conclusion: The protective effect of DPHs extracted from A. officinarum rhizomes against ethanol-induced gastric damages in mice suggests that the extract can be used as an auxiliary supplement for the prevention and treatment of gastric ulcers.]]></abstract>
				<keyword_fa></keyword_fa>
				<keyword>Anti-inflammation, Antioxidant, Diphenylheptane, Gastric protection, Gastric ulcer</keyword>
				<start_page>657</start_page>
				<end_page>665</end_page>
				<web_url>https://ijbms.mums.ac.ir/article_17818.html</web_url>
			<author_list><author>
				<first_name>Kaiwen</first_name>
				<middle_name></middle_name>
				<last_name>Lin</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>kevinlinkaiwen@163.com</email>
				<code>76524</code>
				<coreauthor>No</coreauthor>
				<affiliation>School of Pharmacy, Hainan Medical University, Haikou, China|Hainan Provincial Key Laboratory for Research and Development of Tropical Herbs, Haikou, China|Key Laboratory of Tropical Translational Medicine of Ministry of Education, Haikou, China</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Huijuan</first_name>
				<middle_name></middle_name>
				<last_name>Qu</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>1090750450@qq.com</email>
				<code>76525</code>
				<coreauthor>No</coreauthor>
				<affiliation>School of Pharmacy, Hainan Medical University, Haikou, China|Hainan Provincial Key Laboratory for Research and Development of Tropical Herbs, Haikou, China|Key Laboratory of Tropical Translational Medicine of Ministry of Education, Haikou, China</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Yinfeng</first_name>
				<middle_name></middle_name>
				<last_name>Tan</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>112552819@qq.com</email>
				<code>76526</code>
				<coreauthor>No</coreauthor>
				<affiliation>School of Pharmacy, Hainan Medical University, Haikou, China|Hainan Provincial Key Laboratory for Research and Development of Tropical Herbs, Haikou, China|Key Laboratory of Tropical Translational Medicine of Ministry of Education, Haikou, China</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Tang</first_name>
				<middle_name></middle_name>
				<last_name>Deng</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>45917823@qq.com</email>
				<code>76527</code>
				<coreauthor>No</coreauthor>
				<affiliation>School of Pharmacy, Hainan Medical University, Haikou, China|Intervention Vascular Surgery of First Affiliated Hospital of Hainan Medical University, Haikou, China|Key Laboratory of Emergency and Trauma of Hainan Medical University, Ministry of Education, Haikou, China</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Bingmiao</first_name>
				<middle_name></middle_name>
				<last_name>Gao</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>gaobingmiao@hainmc.edu.cn</email>
				<code>76528</code>
				<coreauthor>No</coreauthor>
				<affiliation>School of Pharmacy, Hainan Medical University, Haikou, China|Hainan Provincial Key Laboratory for Research and Development of Tropical Herbs, Haikou, China|Key Laboratory of Tropical Translational Medicine of Ministry of Education, Haikou, China</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Na</first_name>
				<middle_name></middle_name>
				<last_name>Wei</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>weina-0613@163.com</email>
				<code>76529</code>
				<coreauthor>Yes</coreauthor>
				<affiliation>School of Pharmacy, Hainan Medical University, Haikou, China|Hainan Provincial Key Laboratory for Research and Development of Tropical Herbs, Haikou, China|Key Laboratory of Tropical Translational Medicine of Ministry of Education, Haikou, China</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author></author_list>
				</article>
			</articleset>
			</journal>