<?xml version="1.0" encoding="utf-8"?>
			<journal>
			<title>Iranian Journal of Basic Medical Sciences</title>
			<title_fa></title_fa>
			<short_title></short_title>
			<subject>Medical Sciences</subject>
			<web_url>https://ijbms.mums.ac.ir/</web_url>
			<journal_hbi_system_id>0</journal_hbi_system_id>
			<journal_hbi_system_user></journal_hbi_system_user>
			<journal_id_issn>2008-3866</journal_id_issn>
			<journal_id_issn_online>2008-3874</journal_id_issn_online>
			<journal_id_pii></journal_id_pii>
			<journal_id_doi></journal_id_doi>
			<journal_id_iranmedex></journal_id_iranmedex>
			<journal_id_magiran></journal_id_magiran>
			<journal_id_sid></journal_id_sid>
			<journal_id_nlai></journal_id_nlai>
			<journal_id_science></journal_id_science>
			<language>en</language>
			<pubdate>
				<type>jalali</type>
				<year>0</year>
				<month>0</month>
				<day>1</day>
			</pubdate>
			<pubdate>
				<type>gregorian</type>
				<year>2022</year>
				<month>1</month>
				<day>1</day>
			</pubdate>
			<volume>25</volume>
			<number>1</number>
			<publish_type>online</publish_type>
			<publish_edition>1</publish_edition>
			<article_type>fulltext</article_type>
			<articleset><article>
				<language>en</language>
				<article_id_issn></article_id_issn>
				<article_id_issn_online></article_id_issn_online>
				<article_id_pubmed></article_id_pubmed>
				<article_id_pii></article_id_pii>
				<article_id_doi></article_id_doi>
				<article_id_iranmedex></article_id_iranmedex>
				<article_id_magiran></article_id_magiran>
				<article_id_sid></article_id_sid>
				<title_fa></title_fa>
				<title>Hepatitis B virus X mediates podocyte pyroptosis by regulating the ROS/NLRP3 signaling pathway in hepatitis B virus-associated glomerulonephritis</title>
				<subject_fa></subject_fa>
				<subject></subject>
				<content_type_fa></content_type_fa>
				<content_type>Original Article</content_type>
				<abstract_fa><![CDATA[]]></abstract_fa>
				<abstract><![CDATA[Objective(s): This study was designed to investigate whether HBx-induced podocyte injury is related to the nucleotide-binding oligomerization domain-like receptor protein 3 (NLRP3) inflammasome and the specific mechanism of the oxidative stress pathway in hepatitis B virus-associated glomerulonephritis (HBV-GN).Materials and Methods: The HBx gene was overexpressed in renal podocytes to mimic HBV-GN. Podocyte morphology was observed under a scanning electron microscope. Reactive oxygen species (ROS) generation was detected by dichlorodihydrofluorescein diacetate (DCFH-DA) assay. The podocytes in each group were treated with Hoechst 33342 and subjected to immunofluorescence staining. Caspase-1 activity and LDH levels were assessed with a Caspase-1 Activity Assay Kit and an LDH ELISA Kit, respectively. The expression of all pyroptosis-related proteins was examined by Western blot analysis.Results: Pyroptosis-related proteins, including NLRP3, apoptosis-associated speck-like protein containing card (ASC), caspase-1, IL-1β, and IL-18 (P&lt;0.05), were up-regulated upon HBx overexpression, and caspase-1 enzyme activity and LDH and Desmin expression were also enhanced (P&lt;0.05). NLRP3 knockdown attenuated the increased expression of pyroptosis-related proteins upon HBx overexpression (P&lt;0.05), which was also achieved by the addition of an ROS inhibitor (P&lt;0.05).Conclusion: HBx regulates podocyte pyroptosis in HBV-GN by targeting the NLRP3 inflammasome, and mitochondrial oxidative stress plays an important role in this process.]]></abstract>
				<keyword_fa></keyword_fa>
				<keyword>Glomerulonephritis, HBx, NLRP3, Pyroptosis, ROS</keyword>
				<start_page>103</start_page>
				<end_page>109</end_page>
				<web_url>https://ijbms.mums.ac.ir/article_19488.html</web_url>
			<author_list><author>
				<first_name>Yani</first_name>
				<middle_name></middle_name>
				<last_name>Yu</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>www.yaniyu1997@163.com</email>
				<code>84053</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Nephrology, The Affiliated Hospital of Qingdao University, Qingdao 266003, Shandong, China</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Hui</first_name>
				<middle_name></middle_name>
				<last_name>Dong</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>www.donghui19751003@163.com</email>
				<code>84054</code>
				<coreauthor>No</coreauthor>
				<affiliation>Health Management Center, The Affiliated Hospital of Qingdao University, Qingdao 266003, Shandong, China</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Jingyi</first_name>
				<middle_name></middle_name>
				<last_name>Sun</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>www.964228125@qq.com</email>
				<code>84055</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Nephrology, The Affiliated Hospital of Qingdao University, Qingdao 266003, Shandong, China</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Baoshuang</first_name>
				<middle_name></middle_name>
				<last_name>Li</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>www.libaoshuang1234@163.com</email>
				<code>84056</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Nephrology, The Affiliated Hospital of Qingdao University, Qingdao 266003, Shandong, China</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Yueqi</first_name>
				<middle_name></middle_name>
				<last_name>Chen</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>www.1561213136@qq.com</email>
				<code>84057</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Nephrology, The Affiliated Hospital of Qingdao University, Qingdao 266003, Shandong, China</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Moxuan</first_name>
				<middle_name></middle_name>
				<last_name>Feng</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>www.fengmoxuan717@163.com</email>
				<code>84058</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Nephrology, The Affiliated Hospital of Qingdao University, Qingdao 266003, Shandong, China</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Xiaoqian</first_name>
				<middle_name></middle_name>
				<last_name>Yang</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>www.18363990768@163.com</email>
				<code>84059</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Nephrology, The Affiliated Hospital of Qingdao University, Qingdao 266003, Shandong, China</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Wei</first_name>
				<middle_name></middle_name>
				<last_name>Jiang</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>jwqyfy@163.com</email>
				<code>84060</code>
				<coreauthor>Yes</coreauthor>
				<affiliation>Department of Nephrology, The Affiliated Hospital of Qingdao University, Qingdao 266003, Shandong, China</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author></author_list>
				</article>
			</articleset>
			</journal>