<?xml version="1.0" encoding="utf-8"?>
			<journal>
			<title>Iranian Journal of Basic Medical Sciences</title>
			<title_fa></title_fa>
			<short_title></short_title>
			<subject>Medical Sciences</subject>
			<web_url>https://ijbms.mums.ac.ir/</web_url>
			<journal_hbi_system_id>0</journal_hbi_system_id>
			<journal_hbi_system_user></journal_hbi_system_user>
			<journal_id_issn>2008-3866</journal_id_issn>
			<journal_id_issn_online>2008-3874</journal_id_issn_online>
			<journal_id_pii></journal_id_pii>
			<journal_id_doi></journal_id_doi>
			<journal_id_iranmedex></journal_id_iranmedex>
			<journal_id_magiran></journal_id_magiran>
			<journal_id_sid></journal_id_sid>
			<journal_id_nlai></journal_id_nlai>
			<journal_id_science></journal_id_science>
			<language>en</language>
			<pubdate>
				<type>jalali</type>
				<year>0</year>
				<month>0</month>
				<day>1</day>
			</pubdate>
			<pubdate>
				<type>gregorian</type>
				<year>2022</year>
				<month>3</month>
				<day>1</day>
			</pubdate>
			<volume>25</volume>
			<number>3</number>
			<publish_type>online</publish_type>
			<publish_edition>1</publish_edition>
			<article_type>fulltext</article_type>
			<articleset><article>
				<language>en</language>
				<article_id_issn></article_id_issn>
				<article_id_issn_online></article_id_issn_online>
				<article_id_pubmed></article_id_pubmed>
				<article_id_pii></article_id_pii>
				<article_id_doi></article_id_doi>
				<article_id_iranmedex></article_id_iranmedex>
				<article_id_magiran></article_id_magiran>
				<article_id_sid></article_id_sid>
				<title_fa></title_fa>
				<title>Protective effects of tanshinone I against cisplatin-induced nephrotoxicity in mice</title>
				<subject_fa></subject_fa>
				<subject></subject>
				<content_type_fa></content_type_fa>
				<content_type>Short Communication</content_type>
				<abstract_fa><![CDATA[]]></abstract_fa>
				<abstract><![CDATA[Objective(s): Cisplatin (CDDP) is a highly effective chemotherapeutic agent, but its clinical application has been limited by nephrotoxicity. Tanshinone Ⅰ (T-I), a phenanthrenequinone compound extracted from the Chinese herb Danshen, has been used to improve circulation and treat cardiovascular diseases. The aim of this study was to investigate the protective effect of T-I on CDDP-induced nephrotoxicity in mice.Materials and Methods: The BALB/c mouse models of nephrotoxicity were established by a single intraperitoneal injection of 20 mg/kg CDDP on the first day of the experiment. Three hours prior to CDDP administration, the mice were dosed with 10 mg/kg and 30 mg/kg T-I for 3 consecutive days intraperitoneally to explore nephroprotection of T-I.Results: Treatment with T-I significantly reduced blood urea nitrogen and creatinine levels in serum observed in CDDP-administered mice, especially at a dose of 30 mg/kg. T-I at 30 mg/kg significantly decreased malondialdehyde levels and increased glutathione levels and the enzymatic activity of catalase in kidney tissue compared to CDDP. Additionally, T-I (30 mg/kg) significantly reversed the CDDP-decreased expression level of superoxide dismutase 2 protein in renal tissue. Histopathological evaluation of the kidneys further confirmed the protective effect of T-I. Conclusion: The findings of this study demonstrate that T-I can protect against CDDP-induced nephrotoxicity through suppression of oxidative stress. ]]></abstract>
				<keyword_fa></keyword_fa>
				<keyword>Cisplatin, Mice, Nephrotoxicity, Oxidative stress, Tanshinone Ⅰ</keyword>
				<start_page>414</start_page>
				<end_page>418</end_page>
				<web_url>https://ijbms.mums.ac.ir/article_19684.html</web_url>
			<author_list><author>
				<first_name>Yan</first_name>
				<middle_name></middle_name>
				<last_name>Wang</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>wangyan82033@163.com</email>
				<code>84938</code>
				<coreauthor>Yes</coreauthor>
				<affiliation>Department of Pharmacy, The First College of Clinical Medical Science, China Three Gorges University &amp; Yichang Central People’s Hospital, Yichang 443003, P.R. China</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Yun-hui</first_name>
				<middle_name></middle_name>
				<last_name>Zhang</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>zhangyh75@mail2.sysu.edu.cn</email>
				<code>84939</code>
				<coreauthor>No</coreauthor>
				<affiliation>School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, P.R. China</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Yin-ru</first_name>
				<middle_name></middle_name>
				<last_name>Tang</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>1436202171@qq.com</email>
				<code>84940</code>
				<coreauthor>No</coreauthor>
				<affiliation>School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, P.R. China</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Jie</first_name>
				<middle_name></middle_name>
				<last_name>Lan</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>jielanjane98@163.com</email>
				<code>84941</code>
				<coreauthor>No</coreauthor>
				<affiliation>School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, P.R. China</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Zhi-ying</first_name>
				<middle_name></middle_name>
				<last_name>Huang</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>hzhiying@mail.sysu.edu.cn</email>
				<code>84942</code>
				<coreauthor>No</coreauthor>
				<affiliation>School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, P.R. China</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Wei</first_name>
				<middle_name></middle_name>
				<last_name>Tian</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>malaxiaowei@126.com</email>
				<code>84943</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Pharmacy, The First College of Clinical Medical Science, China Three Gorges University &amp; Yichang Central People’s Hospital, Yichang 443003, P.R. China</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Qian</first_name>
				<middle_name></middle_name>
				<last_name>Huang</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>qianh017@163.com</email>
				<code>84944</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Nephrology, The First College of Clinical Medical Science, China Three Gorges University &amp; Yichang Central People’s Hospital, Yichang 443003, P.R. China</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Yan</first_name>
				<middle_name></middle_name>
				<last_name>Peng</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>2573003586@qq.com</email>
				<code>84945</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Pharmacy, The First College of Clinical Medical Science, China Three Gorges University &amp; Yichang Central People’s Hospital, Yichang 443003, P.R. China</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Yuan</first_name>
				<middle_name></middle_name>
				<last_name>Gao</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>1019658254@qq.com</email>
				<code>84946</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Pharmacy, The First College of Clinical Medical Science, China Three Gorges University &amp; Yichang Central People’s Hospital, Yichang 443003, P.R. China</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Yue-qin</first_name>
				<middle_name></middle_name>
				<last_name>Hu</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>258227314@qq.com</email>
				<code>84947</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Pharmacy, The First College of Clinical Medical Science, China Three Gorges University &amp; Yichang Central People’s Hospital, Yichang 443003, P.R. China</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Xue-nong</first_name>
				<middle_name></middle_name>
				<last_name>Zhang</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>13986258801@163.com</email>
				<code>84948</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Pharmacy, The First College of Clinical Medical Science, China Three Gorges University &amp; Yichang Central People’s Hospital, Yichang 443003, P.R. China</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author></author_list>
				</article>
			</articleset>
			</journal>