<?xml version="1.0" encoding="utf-8"?>
			<journal>
			<title>Iranian Journal of Basic Medical Sciences</title>
			<title_fa></title_fa>
			<short_title></short_title>
			<subject>Medical Sciences</subject>
			<web_url>https://ijbms.mums.ac.ir/</web_url>
			<journal_hbi_system_id>0</journal_hbi_system_id>
			<journal_hbi_system_user></journal_hbi_system_user>
			<journal_id_issn>2008-3866</journal_id_issn>
			<journal_id_issn_online>2008-3874</journal_id_issn_online>
			<journal_id_pii></journal_id_pii>
			<journal_id_doi></journal_id_doi>
			<journal_id_iranmedex></journal_id_iranmedex>
			<journal_id_magiran></journal_id_magiran>
			<journal_id_sid></journal_id_sid>
			<journal_id_nlai></journal_id_nlai>
			<journal_id_science></journal_id_science>
			<language>en</language>
			<pubdate>
				<type>jalali</type>
				<year>0</year>
				<month>0</month>
				<day>1</day>
			</pubdate>
			<pubdate>
				<type>gregorian</type>
				<year>2023</year>
				<month>6</month>
				<day>1</day>
			</pubdate>
			<volume>26</volume>
			<number>6</number>
			<publish_type>online</publish_type>
			<publish_edition>1</publish_edition>
			<article_type>fulltext</article_type>
			<articleset><article>
				<language>en</language>
				<article_id_issn></article_id_issn>
				<article_id_issn_online></article_id_issn_online>
				<article_id_pubmed></article_id_pubmed>
				<article_id_pii></article_id_pii>
				<article_id_doi></article_id_doi>
				<article_id_iranmedex></article_id_iranmedex>
				<article_id_magiran></article_id_magiran>
				<article_id_sid></article_id_sid>
				<title_fa></title_fa>
				<title>Irisin attenuates angiotensin II-induced atrial fibrillation and atrial fibrosis via LOXL2 and TGFβ1/Smad2/3 signaling pathways</title>
				<subject_fa></subject_fa>
				<subject></subject>
				<content_type_fa></content_type_fa>
				<content_type>Original Article</content_type>
				<abstract_fa><![CDATA[]]></abstract_fa>
				<abstract><![CDATA[Objective(s): Irisin was reported as a cardioprotective and anti-oxidative effector, while the effect on atrial fibrosis is unknown. The current research examined irisin’s function in atrial fibrillation (AF); atrial fibrosis brought on by Ang II can be suppressed, thus lessening the risk of developing AF. Materials and Methods: 246 individuals were enrolled in the present case-control study. Chinese AF patients (n=126), 83 of whom were paroxysmal AF (PAF), 43 patients with persistent AF (PeAF), and 120 healthy controls. Saline or Ang II (2.0 mg/kg/day) was subcutaneously injected into healthy male C57BL/6 mice for four weeks. Once daily for four weeks, intraperitoneal injections of exogenous irisin (500 g/kg/day) were administered. Results: In comparison to PAF patients and healthy controls (all P&lt;0.05), PeAF patients had significantly higher rates of heart failure (HF), large left atrial size (LAD), hypertrophic protein B-type natriuretic peptide (BNP), malondialdehyde (MDA), tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), C-terminal telopeptide of type I collagen (CTX-I), and transforming growth factor beta-1 (TGF-β1), while superoxide dismutase (SOD) level was low. Expression of irisin was decreased in AF patients’ serum and Ang II-infused mice. Exogenous irisin dramatically reduced apoptosis, atrial fibrosis, atrial inflammation, and the susceptibility to AF caused by Ang II. In the atrial tissue, irisin inhibited Ang II-induced fibroblast transdifferentiation, LOXL2, TGF-β1, collagen production, and phosphorylation of Smad2/3. Conclusion: The study results speculated that irisin could be a potential AF target, and it inhibited atrial fibrosis and significantly impaired increased AF susceptibility through inactivation of LOXL2 and the TGF-β/Smad pathway.]]></abstract>
				<keyword_fa></keyword_fa>
				<keyword>Angiotensin II, Atrial fibrillation, Atrial fibrosis, Irisin, Lysyl oxidase (LOX)-like-2, Transforming growth factor-beta/Smad</keyword>
				<start_page>717</start_page>
				<end_page>724</end_page>
				<web_url>https://ijbms.mums.ac.ir/article_22113.html</web_url>
			<author_list><author>
				<first_name>Yingbiao</first_name>
				<middle_name></middle_name>
				<last_name>Wu</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>wuyingbiao1981@163.com</email>
				<code>96226</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Cardiology, Shanghai University of Medicine &amp; Health Sciences affiliated Zhoupu Hospital, Shanghai 201318, China</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Jun</first_name>
				<middle_name></middle_name>
				<last_name>Luo</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>13661963096@163.com</email>
				<code>96227</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Cardiology, Shanghai University of Medicine &amp; Health Sciences affiliated Zhoupu Hospital, Shanghai 201318, China</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Xiang</first_name>
				<middle_name></middle_name>
				<last_name>Song</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>song761231@sina.com</email>
				<code>96228</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Cardiology, Shanghai University of Medicine &amp; Health Sciences affiliated Zhoupu Hospital, Shanghai 201318, China</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Wei</first_name>
				<middle_name></middle_name>
				<last_name>Gu</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>gw12241224@sina.com</email>
				<code>96229</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Cardiology, Shanghai University of Medicine &amp; Health Sciences affiliated Zhoupu Hospital, Shanghai 201318, China</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Saihua</first_name>
				<middle_name></middle_name>
				<last_name>Wang</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>shwang1313@163.com</email>
				<code>96230</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Cardiology, Shanghai University of Medicine &amp; Health Sciences affiliated Zhoupu Hospital, Shanghai 201318, China</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Shuwen</first_name>
				<middle_name></middle_name>
				<last_name>Hao</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>fu5288@hotmail.com</email>
				<code>96231</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Cardiology, Shanghai University of Medicine &amp; Health Sciences affiliated Zhoupu Hospital, Shanghai 201318, China</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Zhiwu</first_name>
				<middle_name></middle_name>
				<last_name>Dong</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>dzw2017@163.com</email>
				<code>96232</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Cardiology, People’s Hospital of Shache County, Xinjiang, 844700, China</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Zhongping</first_name>
				<middle_name></middle_name>
				<last_name>Ning</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>ningzpsh@163.com</email>
				<code>96233</code>
				<coreauthor>Yes</coreauthor>
				<affiliation>Department of Cardiology, Shanghai University of Medicine &amp; Health Sciences affiliated Zhoupu Hospital, Shanghai 201318, China</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author></author_list>
				</article>
			</articleset>
			</journal>