<?xml version="1.0" encoding="utf-8"?>
			<journal>
			<title>Iranian Journal of Basic Medical Sciences</title>
			<title_fa></title_fa>
			<short_title></short_title>
			<subject>Medical Sciences</subject>
			<web_url>https://ijbms.mums.ac.ir/</web_url>
			<journal_hbi_system_id>0</journal_hbi_system_id>
			<journal_hbi_system_user></journal_hbi_system_user>
			<journal_id_issn>2008-3866</journal_id_issn>
			<journal_id_issn_online>2008-3874</journal_id_issn_online>
			<journal_id_pii></journal_id_pii>
			<journal_id_doi></journal_id_doi>
			<journal_id_iranmedex></journal_id_iranmedex>
			<journal_id_magiran></journal_id_magiran>
			<journal_id_sid></journal_id_sid>
			<journal_id_nlai></journal_id_nlai>
			<journal_id_science></journal_id_science>
			<language>en</language>
			<pubdate>
				<type>jalali</type>
				<year>2023</year>
				<month>11</month>
				<day>1</day>
			</pubdate>
			<pubdate>
				<type>gregorian</type>
				<year>2023</year>
				<month>11</month>
				<day>1</day>
			</pubdate>
			<volume>26</volume>
			<number>11</number>
			<publish_type>online</publish_type>
			<publish_edition>1</publish_edition>
			<article_type>fulltext</article_type>
			<articleset><article>
				<language>en</language>
				<article_id_issn></article_id_issn>
				<article_id_issn_online></article_id_issn_online>
				<article_id_pubmed></article_id_pubmed>
				<article_id_pii></article_id_pii>
				<article_id_doi></article_id_doi>
				<article_id_iranmedex></article_id_iranmedex>
				<article_id_magiran></article_id_magiran>
				<article_id_sid></article_id_sid>
				<title_fa></title_fa>
				<title>Peroxiredoxin 1 alleviates oxygen-glucose deprivation/ reoxygenation injury in N2a cells via suppressing the JNK/caspase-3 pathway</title>
				<subject_fa></subject_fa>
				<subject></subject>
				<content_type_fa></content_type_fa>
				<content_type>Original Article</content_type>
				<abstract_fa><![CDATA[]]></abstract_fa>
				<abstract><![CDATA[Objective(s): Cerebral ischemia/reperfusion (I/R) injury inevitably aggravates the initial cerebral tissue damage following a stroke. Peroxiredoxin 1 (Prdx1) is a representative protein of the endogenous antioxidant enzyme family that regulates several reactive oxygen species (ROS)-dependent signaling pathways, whereas the JNK/caspase-3 proapoptotic pathway has a prominent role during cerebral I/R injury. This study aimed to examine the potential mechanism of Prdx1 in Neuro 2A (N2a) cells following oxygen–glucose deprivation and reoxygenation (OGD/R) injury. Materials and Methods: N2a cells were exposed to OGD/R to simulate cerebral I/R injury. Prdx1 siRNA transfection and the JNK inhibitor (SP600125) were used to interfere with their relative expressions. CCK-8 assay, flow cytometry, and lactate dehydrogenase (LDH) assay were employed to determine the viability and apoptosis of N2a cells. The intracellular ROS content was assessed using ROS Assay Kit. Real-time quantitative reverse transcription polymerase chain reaction (qRT-PCR) and western blot analyses were conducted to detect the expression levels of Prdx1, JNK, phosphorylated JNK (p-JNK), and cleaved caspase-3. Results: Firstly, Prdx1, p-JNK, and cleaved caspase-3 expression were significantly induced in OGD/R-exposed N2a cells. Secondly, the knockdown of Prdx1 inhibited cell viability and increased apoptosis rate, expression of p-JNK, and cleaved caspase-3 expression. Thirdly, SP600125 inhibited the JNK/caspase-3 signaling pathway and mitigated cell injury following OGD/R. Finally, SP600125 partially reversed Prdx1 down-regulation-mediated cleaved caspase-3 activation and OGD/R damage in N2a cells. Conclusion: Prdx1 alleviates the injury to N2a cells induced by OGD/R via suppressing JNK/caspase-3 pathway, showing promise as a potential therapeutic for cerebral I/R injury.]]></abstract>
				<keyword_fa></keyword_fa>
				<keyword>Caspase-3, Cell Hypoxia, c-Jun N-terminal kinase, Mice, Neuroblastoma, Peroxiredoxin 1, Reperfusion injury</keyword>
				<start_page>1305</start_page>
				<end_page>1312</end_page>
				<web_url>https://ijbms.mums.ac.ir/article_22706.html</web_url>
			<author_list><author>
				<first_name>Yang</first_name>
				<middle_name></middle_name>
				<last_name>Yuan</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>lillian931220@163.com</email>
				<code>99055</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Anesthesiology, Qingdao Municipal Hospital, Qingdao, Shandong, China</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Hongchen</first_name>
				<middle_name></middle_name>
				<last_name>Tan</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>tanhc2000@163.com</email>
				<code>99056</code>
				<coreauthor>No</coreauthor>
				<affiliation>Malvern College Qingdao, Qingdao, Shandong, China</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Huailong</first_name>
				<middle_name></middle_name>
				<last_name>Chen</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>haifeng99958@sina.com</email>
				<code>99057</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Anesthesiology, Qingdao Eight People’s Hospital, Qingdao, Shandong, China</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Jiawen</first_name>
				<middle_name></middle_name>
				<last_name>Zhang</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>15909482303@163.com</email>
				<code>99058</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Anesthesiology, Qingdao Clinical College Affiliated to Nanjing Medical University, Qingdao, Shandong, China</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Fei</first_name>
				<middle_name></middle_name>
				<last_name>Shi</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>shifeiqingdao@163.com</email>
				<code>99059</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Anesthesiology, Qingdao Municipal Hospital, Qingdao, Shandong, China</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Mingshan</first_name>
				<middle_name></middle_name>
				<last_name>Wang</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>wmsqingdao@163.com</email>
				<code>99060</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Anesthesiology, Qingdao Municipal Hospital, Qingdao, Shandong, China</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Gaofeng</first_name>
				<middle_name></middle_name>
				<last_name>Zhang</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>exgalaxy@163.com</email>
				<code>99061</code>
				<coreauthor>Yes</coreauthor>
				<affiliation>Department of Anesthesiology, Qingdao Municipal Hospital, Qingdao, Shandong, China</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Haipeng</first_name>
				<middle_name></middle_name>
				<last_name>Wang</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>haipengqingdao@163.com</email>
				<code>99062</code>
				<coreauthor>Yes</coreauthor>
				<affiliation>Department of Anesthesiology, Weifang No.2 People’s Hospital, Weifang, Shandong, China</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Rui</first_name>
				<middle_name></middle_name>
				<last_name>Dong</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>dongrui@whu.edu.cn</email>
				<code>99063</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Anesthesiology, Qingdao Municipal Hospital, Qingdao, Shandong, China</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author></author_list>
				</article>
			</articleset>
			</journal>