<?xml version="1.0" encoding="utf-8"?>
			<journal>
			<title>Iranian Journal of Basic Medical Sciences</title>
			<title_fa></title_fa>
			<short_title></short_title>
			<subject>Medical Sciences</subject>
			<web_url>https://ijbms.mums.ac.ir/</web_url>
			<journal_hbi_system_id>0</journal_hbi_system_id>
			<journal_hbi_system_user></journal_hbi_system_user>
			<journal_id_issn>2008-3866</journal_id_issn>
			<journal_id_issn_online>2008-3874</journal_id_issn_online>
			<journal_id_pii></journal_id_pii>
			<journal_id_doi></journal_id_doi>
			<journal_id_iranmedex></journal_id_iranmedex>
			<journal_id_magiran></journal_id_magiran>
			<journal_id_sid></journal_id_sid>
			<journal_id_nlai></journal_id_nlai>
			<journal_id_science></journal_id_science>
			<language>en</language>
			<pubdate>
				<type>jalali</type>
				<year>2024</year>
				<month>5</month>
				<day>1</day>
			</pubdate>
			<pubdate>
				<type>gregorian</type>
				<year>2024</year>
				<month>5</month>
				<day>1</day>
			</pubdate>
			<volume>27</volume>
			<number>5</number>
			<publish_type>online</publish_type>
			<publish_edition>1</publish_edition>
			<article_type>fulltext</article_type>
			<articleset><article>
				<language>en</language>
				<article_id_issn></article_id_issn>
				<article_id_issn_online></article_id_issn_online>
				<article_id_pubmed></article_id_pubmed>
				<article_id_pii></article_id_pii>
				<article_id_doi></article_id_doi>
				<article_id_iranmedex></article_id_iranmedex>
				<article_id_magiran></article_id_magiran>
				<article_id_sid></article_id_sid>
				<title_fa></title_fa>
				<title>Genista cephalantha Spach. protects against acetaminophen-induced liver failure via preserving the glutathione redox system, reducing inﬂammatory response, and inhibiting hepatocyte death in rats</title>
				<subject_fa></subject_fa>
				<subject></subject>
				<content_type_fa></content_type_fa>
				<content_type>Original Article</content_type>
				<abstract_fa><![CDATA[]]></abstract_fa>
				<abstract><![CDATA[Objective(s): The current study was conducted to assess the protective mechanisms of n-BuOH fraction from the aerial part of Genista cephontala (BEGC) on APAP-induced liver injury compared to necrostatine-1 (Nec-1).Materials and Methods: A model of APAP-induced hepatotoxicity was created in male rats by injecting a single dose; 1000 mg/kg APAP, the protective effect was performed with (200 mg/kg; 10 days) BEGC compared to Nec-1, (1.8 mg/kg).Results: BEGC or NeC-1 pretreatment significantly abolished impaired effects in APAP-rats, by decreasing the generation of TBARS and ROS in mitochondrial and cytosolic fractions and maintaining liver function activities. A marked response was observed in the levels of both GSH and GSH-system enzymes in liver homogenates and mitochondrial fractions to BEGC. BEGC/ Nec-1 successfully regulated the inflammatory mediators (IL-β, TNF-α, HMGB1, and acHMGB1) and MPO levels. During APAP treatment, no caspase-3 or -8 activity was detected, and the level of fk18; M30 was higher than the levels of cck18; M65. Moreover, RIPK3 and MLKL levels were increased in the APAP group. These results suggested that necroptosis predominates during the APAP liver injury model. Interestingly, these necroptotic factors were significantly down-regulated by BEGC treatment. Both biochemical and histopathological findings were consistent with each other.Conclusion: From all these findings, the hepatoprotective effect of BEGC could be due to the abundance of polyphenols identified by LC-MS/MS analysis, as well as the synergistic interactions of all contents.]]></abstract>
				<keyword_fa></keyword_fa>
				<keyword>Acetaminophen, Cell death, Hepatoprotection Inflammation, LC-MS/MS, Necroptosis, Necrostatin-1, Oxidative stress</keyword>
				<start_page>630</start_page>
				<end_page>639</end_page>
				<web_url>https://ijbms.mums.ac.ir/article_23766.html</web_url>
			<author_list><author>
				<first_name>Boulkandoul</first_name>
				<middle_name></middle_name>
				<last_name>Ramzi</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>ramzibio25@hotmail.com</email>
				<code>104001</code>
				<coreauthor>No</coreauthor>
				<affiliation>Laboratoire de Biologie et Environnement. Université Frères Mentouri Constantine 1, Algérie</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Ameddah</first_name>
				<middle_name></middle_name>
				<last_name>Souad</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>amedsouad@yahoo.fr</email>
				<code>104002</code>
				<coreauthor>Yes</coreauthor>
				<affiliation>Laboratoire de Biologie et Environnement. Université Frères Mentouri Constantine 1, Algérie</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Chebbah</first_name>
				<middle_name></middle_name>
				<last_name>Kawthar</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>k.chebbah@gmail.com</email>
				<code>104003</code>
				<coreauthor>No</coreauthor>
				<affiliation>Unité de Recherche, Valorisation des Ressources Naturelles, Molécules Bioactives et Analyses Physicochimiques et Biologiques. Frères Mentouri Constantine 1, Algérie</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Erenler</first_name>
				<middle_name></middle_name>
				<last_name>Ramazan</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>ramazan.erenler@gop.edu.tr</email>
				<code>104004</code>
				<coreauthor>No</coreauthor>
				<affiliation>Research Laboratory Practice and Research Center, Igdir, University Igdir, Turkiye</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Mekkiou</first_name>
				<middle_name></middle_name>
				<last_name>Ratiba</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>mekkiou_ratiba@yahoo.fr</email>
				<code>104005</code>
				<coreauthor>No</coreauthor>
				<affiliation>Unité de Recherche, Valorisation des Ressources Naturelles, Molécules Bioactives et Analyses Physicochimiques et Biologiques. Frères Mentouri Constantine 1, Algérie</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Benayache</first_name>
				<middle_name></middle_name>
				<last_name>Samir</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>sbenayache@yahoo.com</email>
				<code>104006</code>
				<coreauthor>No</coreauthor>
				<affiliation>Unité de Recherche, Valorisation des Ressources Naturelles, Molécules Bioactives et Analyses Physicochimiques et Biologiques. Frères Mentouri Constantine 1, Algérie</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Benayache</first_name>
				<middle_name></middle_name>
				<last_name>Fadila</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>fbenayache@yahoo.com</email>
				<code>104007</code>
				<coreauthor>No</coreauthor>
				<affiliation>Unité de Recherche, Valorisation des Ressources Naturelles, Molécules Bioactives et Analyses Physicochimiques et Biologiques. Frères Mentouri Constantine 1, Algérie</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Ahmed</first_name>
				<middle_name></middle_name>
				<last_name>Menad</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>menadahmed@yahoo.fr</email>
				<code>104008</code>
				<coreauthor>No</coreauthor>
				<affiliation>Laboratoire de Biologie et Environnement. Université Frères Mentouri Constantine 1, Algérie</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author></author_list>
				</article>
			</articleset>
			</journal>