<?xml version="1.0" encoding="utf-8"?>
			<journal>
			<title>Iranian Journal of Basic Medical Sciences</title>
			<title_fa></title_fa>
			<short_title></short_title>
			<subject>Medical Sciences</subject>
			<web_url>https://ijbms.mums.ac.ir/</web_url>
			<journal_hbi_system_id>0</journal_hbi_system_id>
			<journal_hbi_system_user></journal_hbi_system_user>
			<journal_id_issn>2008-3866</journal_id_issn>
			<journal_id_issn_online>2008-3874</journal_id_issn_online>
			<journal_id_pii></journal_id_pii>
			<journal_id_doi></journal_id_doi>
			<journal_id_iranmedex></journal_id_iranmedex>
			<journal_id_magiran></journal_id_magiran>
			<journal_id_sid></journal_id_sid>
			<journal_id_nlai></journal_id_nlai>
			<journal_id_science></journal_id_science>
			<language>en</language>
			<pubdate>
				<type>jalali</type>
				<year>2024</year>
				<month>6</month>
				<day>1</day>
			</pubdate>
			<pubdate>
				<type>gregorian</type>
				<year>2024</year>
				<month>6</month>
				<day>1</day>
			</pubdate>
			<volume>27</volume>
			<number>6</number>
			<publish_type>online</publish_type>
			<publish_edition>1</publish_edition>
			<article_type>fulltext</article_type>
			<articleset><article>
				<language>en</language>
				<article_id_issn></article_id_issn>
				<article_id_issn_online></article_id_issn_online>
				<article_id_pubmed></article_id_pubmed>
				<article_id_pii></article_id_pii>
				<article_id_doi></article_id_doi>
				<article_id_iranmedex></article_id_iranmedex>
				<article_id_magiran></article_id_magiran>
				<article_id_sid></article_id_sid>
				<title_fa></title_fa>
				<title>Alpha-pinene alleviates CCl4-induced renal and testicular injury in rats by targeting oxidative stress, inflammation, and apoptosis</title>
				<subject_fa></subject_fa>
				<subject></subject>
				<content_type_fa></content_type_fa>
				<content_type>Original Article</content_type>
				<abstract_fa><![CDATA[]]></abstract_fa>
				<abstract><![CDATA[Objective(s): Renal and testicular disorders are primarily associated with oxidative damage and inflammation. Here, alpha-pinene (a type of monoterpene) was investigated for its effect on oxidative/nitrosative stress and the expression of inflammatory and apoptotic factors in the kidneys and testes of rats treated with CCl4.Materials and Methods: CCl4 was injected intraperitoneally (IP) at a dose of 2 ml/kg (twice a week for six weeks). Alpha-pinene (50 mg/kg/day, IP) was also treated during the same period. Results: CCl4 increased the level of malondialdehyde (P&lt;0.01 in the kidney and P&lt;0.001 in the testis) and nitric oxide (P&lt;0.001 in the kidney and P&lt;0.01 in the testis) and decreased the levels of glutathione (P&lt;0.05) in the kidneys and testicles of rats. CCl4 also reduced the catalase enzyme activity in the kidneys (P&lt;0.05) but did not affect its activity in the testis. In addition, CCl4 enhanced the mRNA expression of TNF-α (P&lt;0.01), nuclear factor-κB (P&lt;0.05), and Bax (P&lt;0.05 in the kidney and P&lt;0.01 in the testis) and decreased the expression of Bcl-2 (P&lt;0.05) in both organs. Alpha-pinene prevented all the mentioned changes, but it did not influence the expression of Bcl-2 in the kidneys of rats receiving CCl4. Conclusion: Alpha-pinene may have the potential to prevent renal and testicular diseases by strengthening the antioxidant system in the kidneys and testis, and inhibiting oxidative/nitrosative stress, inflammation, and apoptosis caused by CCl4.]]></abstract>
				<keyword_fa></keyword_fa>
				<keyword>Alpha-pinene, bcl-2-Associated X Protein, Inflammation, Kidney, Oxidative stress, Testis</keyword>
				<start_page>678</start_page>
				<end_page>684</end_page>
				<web_url>https://ijbms.mums.ac.ir/article_23896.html</web_url>
			<author_list><author>
				<first_name>Fatemeh</first_name>
				<middle_name></middle_name>
				<last_name>Noroozi</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>farzaneh.norouzi17@gmail.com</email>
				<code>104615</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Physiology, Zanjan Branch, Islamic Azad University, Zanjan, Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Masoumeh</first_name>
				<middle_name></middle_name>
				<last_name>Asle Rousta</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>mrousta58@gmail.com</email>
				<code>104616</code>
				<coreauthor>Yes</coreauthor>
				<affiliation>Department of Physiology, Zanjan Branch, Islamic Azad University, Zanjan, Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Rahim</first_name>
				<middle_name></middle_name>
				<last_name>Amini</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>rahimamini84@gmail.com</email>
				<code>104617</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Biology, Zanjan Branch, Islamic Azad University, Zanjan, Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Zeinab</first_name>
				<middle_name></middle_name>
				<last_name>Sahraeian</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>biosahraeian58@gmail.com</email>
				<code>104618</code>
				<coreauthor>No</coreauthor>
				<affiliation>Nanobiotechnology Research Center, Zanjan Branch, Islamic Azad University, Zanjan, Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author></author_list>
				</article>
			</articleset>
			</journal>