<?xml version="1.0" encoding="utf-8"?>
			<journal>
			<title>Iranian Journal of Basic Medical Sciences</title>
			<title_fa></title_fa>
			<short_title></short_title>
			<subject>Medical Sciences</subject>
			<web_url>https://ijbms.mums.ac.ir/</web_url>
			<journal_hbi_system_id>0</journal_hbi_system_id>
			<journal_hbi_system_user></journal_hbi_system_user>
			<journal_id_issn>2008-3866</journal_id_issn>
			<journal_id_issn_online>2008-3874</journal_id_issn_online>
			<journal_id_pii></journal_id_pii>
			<journal_id_doi></journal_id_doi>
			<journal_id_iranmedex></journal_id_iranmedex>
			<journal_id_magiran></journal_id_magiran>
			<journal_id_sid></journal_id_sid>
			<journal_id_nlai></journal_id_nlai>
			<journal_id_science></journal_id_science>
			<language>en</language>
			<pubdate>
				<type>jalali</type>
				<year>2025</year>
				<month>1</month>
				<day>1</day>
			</pubdate>
			<pubdate>
				<type>gregorian</type>
				<year>2025</year>
				<month>1</month>
				<day>1</day>
			</pubdate>
			<volume>28</volume>
			<number>1</number>
			<publish_type>online</publish_type>
			<publish_edition>1</publish_edition>
			<article_type>fulltext</article_type>
			<articleset><article>
				<language>en</language>
				<article_id_issn></article_id_issn>
				<article_id_issn_online></article_id_issn_online>
				<article_id_pubmed></article_id_pubmed>
				<article_id_pii></article_id_pii>
				<article_id_doi></article_id_doi>
				<article_id_iranmedex></article_id_iranmedex>
				<article_id_magiran></article_id_magiran>
				<article_id_sid></article_id_sid>
				<title_fa></title_fa>
				<title>Ellagic acid alleviates NLRP6/caspase-1/GSDMD-mediated inflammation and pyroptosis in rats post cerebral ischemia/reperfusion injury</title>
				<subject_fa></subject_fa>
				<subject></subject>
				<content_type_fa></content_type_fa>
				<content_type>Original Article</content_type>
				<abstract_fa><![CDATA[]]></abstract_fa>
				<abstract><![CDATA[Objective(s): Ellagic acid (EA) is a natural polyphenol with anti-cancer, anti-oxidant, anti-inflammatory, antibacterial, and other effects. However, the role of EA in cerebral ischemia/reperfusion injury (CIRI) remains unclear. This study aims to investigate the neuroprotective effects of EA in CIRI.Materials and Methods: Forty male Wistar rats (260-300 g) were randomly divided into four groups with 10 rats per group: 1) Sham+Veh: Rats underwent I/R surgery, except that they were not inserted with thread plugs, and received solute treatment at the same time. 2) MCAO/R+Veh. 3) MCAO/R+EA: Rats were administered 200 mg/kg EA before undergoing MCAO. 4) MCAO/R+Nim: Rats were administered Nim before undergoing MCAO.Results: Cerebral MCAO/R damaged brain tissue, elevated neurological deficit score (P&lt;0.01), cerebral infarction volume (P&lt;0.01), inflammatory cell infiltration (P&lt;0.01), NLRP6, ASC, caspase-1 and GSDMD mRNA level (P&lt;0.01 and P&lt;0.001), NLRP6, caspase-1, GSDMD-N and IL-1β protein level (P&lt;0.01 and P&lt;0.001), and inflammatory cytokines in brain tissue (P&lt;0.01). Prophylactic administration of EA also significantly improved brain tissue damage, reduced neurological deficit score (P&lt;0.01), cerebral infarction volume (P&lt;0.01), inflammatory cell number (P&lt;0.05), NLRP6, caspase-1, GSDMD-N mRNA and protein level (P&lt;0.05 and P&lt;0.01), ASC mRNA level and IL-1β protein level (P&lt;0.01), and IL-1β and IL-18 level in brain tissue (P&lt;0.01) compared to positive control.Conclusion: EA may serve as a potential drug for the treatment of brain I/R, which may exert an anti-inflammatory effect by inhibiting the activation of the inflammasome.]]></abstract>
				<keyword_fa></keyword_fa>
				<keyword>Cerebral ischemia/reperfusion injury, Ellagic acid, Inflammation, NLRP6 inflammasome, Pyroptosis</keyword>
				<start_page>105</start_page>
				<end_page>112</end_page>
				<web_url>https://ijbms.mums.ac.ir/article_25031.html</web_url>
			<author_list><author>
				<first_name>Ling</first_name>
				<middle_name></middle_name>
				<last_name>Hu</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>39974043@qq.com</email>
				<code>109766</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Pathology, Chongqing Three Gorges Medical College, Wanzhou, China</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Xiaoqiong</first_name>
				<middle_name></middle_name>
				<last_name>Wei</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>1134651504@qq.com</email>
				<code>109767</code>
				<coreauthor>No</coreauthor>
				<affiliation>Chongqing Three Gorges Medical College, Wanzhou, China</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Guofu</first_name>
				<middle_name></middle_name>
				<last_name>Shen</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>2081453790@qq.com</email>
				<code>109768</code>
				<coreauthor>No</coreauthor>
				<affiliation>Chongqing Three Gorges Medical College, Wanzhou, China</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Xiaohuan</first_name>
				<middle_name></middle_name>
				<last_name>Huang</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>huangxiaohuan@cqtgmc.edu.cn</email>
				<code>109769</code>
				<coreauthor>Yes</coreauthor>
				<affiliation>Department of Pathology, Chongqing Three Gorges Medical College, Wanzhou, China</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author></author_list>
				</article>
			</articleset>
			</journal>