<?xml version="1.0" encoding="utf-8"?>
			<journal>
			<title>Iranian Journal of Basic Medical Sciences</title>
			<title_fa></title_fa>
			<short_title></short_title>
			<subject>Medical Sciences</subject>
			<web_url>https://ijbms.mums.ac.ir/</web_url>
			<journal_hbi_system_id>0</journal_hbi_system_id>
			<journal_hbi_system_user></journal_hbi_system_user>
			<journal_id_issn>2008-3866</journal_id_issn>
			<journal_id_issn_online>2008-3874</journal_id_issn_online>
			<journal_id_pii></journal_id_pii>
			<journal_id_doi></journal_id_doi>
			<journal_id_iranmedex></journal_id_iranmedex>
			<journal_id_magiran></journal_id_magiran>
			<journal_id_sid></journal_id_sid>
			<journal_id_nlai></journal_id_nlai>
			<journal_id_science></journal_id_science>
			<language>en</language>
			<pubdate>
				<type>jalali</type>
				<year>2025</year>
				<month>3</month>
				<day>1</day>
			</pubdate>
			<pubdate>
				<type>gregorian</type>
				<year>2025</year>
				<month>3</month>
				<day>1</day>
			</pubdate>
			<volume>28</volume>
			<number>3</number>
			<publish_type>online</publish_type>
			<publish_edition>1</publish_edition>
			<article_type>fulltext</article_type>
			<articleset><article>
				<language>en</language>
				<article_id_issn></article_id_issn>
				<article_id_issn_online></article_id_issn_online>
				<article_id_pubmed></article_id_pubmed>
				<article_id_pii></article_id_pii>
				<article_id_doi></article_id_doi>
				<article_id_iranmedex></article_id_iranmedex>
				<article_id_magiran></article_id_magiran>
				<article_id_sid></article_id_sid>
				<title_fa></title_fa>
				<title>Investigating the protective effects of fluvoxamine against sepsis-related acute lung injury through antiapoptotic, anti-inflammatory, and anti-oxidant features in rats</title>
				<subject_fa></subject_fa>
				<subject></subject>
				<content_type_fa></content_type_fa>
				<content_type>Original Article</content_type>
				<abstract_fa><![CDATA[]]></abstract_fa>
				<abstract><![CDATA[Objective(s): Acute lung injury (ALI) is characterized by severe hypoxia and alveolar damage, often caused by oxidative stress, endoplasmic reticulum stress (ERS), and apoptosis. Fluvoxamine (FLV), an antidepressant, has tissue-protective properties through various intracellular mechanisms. This study investigates the anti-inflammatory effects of  FLV used as an antidepressant in a lipopolysaccharide (LPS)-induced ALI model.Materials and Methods: Thirty-two female Wistar Albino rats aged 14–16 weeks and weighing 300–350 g, with 8 animals in each group, were divided into four groups: control, LPS, LPS+FLV, and FLV. After LPS administration, rats were euthanized, and histopathological analysis, immunohistochemistry for tumor necrosis factor-α (TNF-α) and caspase-3 (Cas-3), ELISA for oxidative stress markers, and PCR for CHOP, Cas-12, and Cas-9 gene expressions were conducted.Results: In the LPS group, lung tissue damage, increased inflammatory cell infiltration, increased Cas-3 and TNF-α expressions, increased oxidative stress markers, and increased CHOP, Cas-9, and Cas-12 mRNA expressions were observed compared to the control group. FLV treatment in the LPS+FLV group significantly reversed these effects in the LPS group.Conclusion: FLV exhibits protective effects against ALI by mitigating inflammation, ERS, and apoptosis via the CHOP/Cas-9/Cas-12 pathway. Further studies are needed to explore additional pathways and potential clinical applications of FLV.]]></abstract>
				<keyword_fa></keyword_fa>
				<keyword>ER stress, Inflammation, Lipopolysaccharide, Rat, Respiratory System, SSRI</keyword>
				<start_page>323</start_page>
				<end_page>331</end_page>
				<web_url>https://ijbms.mums.ac.ir/article_25368.html</web_url>
			<author_list><author>
				<first_name>Halil</first_name>
				<middle_name></middle_name>
				<last_name>Asci</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>halilasci@sdu.edu.tr</email>
				<code>111321</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Pharmacology, Faculty of Medicine, Suleyman Demirel University, Isparta, Turkey|Department of Bioengineering, Institute of Science and Technology, Suleyman Demirel University Isparta, Turkey</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Suleyman Emre</first_name>
				<middle_name></middle_name>
				<last_name>Akin</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>suleymanakin@sdu.edu.tr</email>
				<code>111322</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Thoracic Surgery, Faculty of Medicine, Suleyman Demirel University, Isparta, Turkey</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Hasan Ekrem</first_name>
				<middle_name></middle_name>
				<last_name>Camas</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>hasancamas@sdu.edu.tr</email>
				<code>111323</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Thoracic Surgery, Faculty of Medicine, Suleyman Demirel University, Isparta, Turkey</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Ahmet</first_name>
				<middle_name></middle_name>
				<last_name>Bindal</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>dr.ahmetbindal@gmail.com</email>
				<code>111324</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Anesthesiology and Reanimation, Suleyman Demirel University, Isparta, Turkey</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Okan</first_name>
				<middle_name></middle_name>
				<last_name>Kurtbolat</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>okankurtbolat@gmail.com</email>
				<code>111325</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Pharmacology, Faculty of Medicine, Suleyman Demirel University, Isparta, Turkey</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Şerife</first_name>
				<middle_name></middle_name>
				<last_name>Tasan</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>vethekserifeagirca@gmail.com</email>
				<code>111326</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Pathology, Faculty of Veterinary Medicine, Burdur Mehmet Akif Ersoy University, Burdur, Turkey</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Abdurrahman</first_name>
				<middle_name></middle_name>
				<last_name>Gulal</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>agulal@hotmail.com</email>
				<code>111327</code>
				<coreauthor>No</coreauthor>
				<affiliation>Veterinarian, Isparta, Turkey</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Rumeysa</first_name>
				<middle_name></middle_name>
				<last_name>Taner</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>rrumeysataner@gmail.com</email>
				<code>111328</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Bioengineering, Institute of Science and Technology, Suleyman Demirel University Isparta, Turkey</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Turgut</first_name>
				<middle_name></middle_name>
				<last_name>Kurt</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>turgutkurt@sdu.edu.tr</email>
				<code>111329</code>
				<coreauthor>No</coreauthor>
				<affiliation>Veterinary Technician, Faculty of Medicine, Suleyman Demirel University Isparta, Turkey</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Ozlem</first_name>
				<middle_name></middle_name>
				<last_name>Ozmen</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>ozlemozmen@mehmetakif.edu.tr</email>
				<code>111330</code>
				<coreauthor>Yes</coreauthor>
				<affiliation>Department of Pathology, Faculty of Veterinary Medicine, Burdur Mehmet Akif Ersoy University, Burdur, Turkey</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author></author_list>
				</article>
			</articleset>
			</journal>