<?xml version="1.0" encoding="utf-8"?>
			<journal>
			<title>Iranian Journal of Basic Medical Sciences</title>
			<title_fa></title_fa>
			<short_title></short_title>
			<subject>Medical Sciences</subject>
			<web_url>https://ijbms.mums.ac.ir/</web_url>
			<journal_hbi_system_id>0</journal_hbi_system_id>
			<journal_hbi_system_user></journal_hbi_system_user>
			<journal_id_issn>2008-3866</journal_id_issn>
			<journal_id_issn_online>2008-3874</journal_id_issn_online>
			<journal_id_pii></journal_id_pii>
			<journal_id_doi></journal_id_doi>
			<journal_id_iranmedex></journal_id_iranmedex>
			<journal_id_magiran></journal_id_magiran>
			<journal_id_sid></journal_id_sid>
			<journal_id_nlai></journal_id_nlai>
			<journal_id_science></journal_id_science>
			<language>en</language>
			<pubdate>
				<type>jalali</type>
				<year>0</year>
				<month>0</month>
				<day>1</day>
			</pubdate>
			<pubdate>
				<type>gregorian</type>
				<year>2025</year>
				<month>5</month>
				<day>1</day>
			</pubdate>
			<volume>28</volume>
			<number>5</number>
			<publish_type>online</publish_type>
			<publish_edition>1</publish_edition>
			<article_type>fulltext</article_type>
			<articleset><article>
				<language>en</language>
				<article_id_issn></article_id_issn>
				<article_id_issn_online></article_id_issn_online>
				<article_id_pubmed></article_id_pubmed>
				<article_id_pii></article_id_pii>
				<article_id_doi></article_id_doi>
				<article_id_iranmedex></article_id_iranmedex>
				<article_id_magiran></article_id_magiran>
				<article_id_sid></article_id_sid>
				<title_fa></title_fa>
				<title>Synergistic effects of cryoablation and GM-CSF in colorectal liver metastases management in tumor-bearing mice</title>
				<subject_fa></subject_fa>
				<subject></subject>
				<content_type_fa></content_type_fa>
				<content_type>Original Article</content_type>
				<abstract_fa><![CDATA[]]></abstract_fa>
				<abstract><![CDATA[Objective(s): The use of cryoablation for colorectal liver metastases (CLM) remains limited and controversial. This study aimed to investigate the antitumor immune response following cryoablation combined with granulocyte-macrophage colony-stimulating factor (GM-CSF) treatment in a CLM mouse model.Materials and Methods: A CLM mouse model was established using BALB/c mice. The tumor-bearing mice were randomly divided into Control group, GM-CSF group, cryoablation group, and cryoablation + GM-CSF group. Tumor size, survival time, dendritic cells (DCs) count, serum cytokine levels (IL-4, IFN-γ), and the Th1/Th2 ratio (IFN-γ/IL-4) were compared among the four groups.Results: The combination of cryoablation and GM-CSF demonstrated synergistic effects, resulting in the smallest tumor lesion, longest mean survival time, and highest DC count on day 21 post-treatment compared to other groups. Both cryoablation alone and combined with GM-CSF significantly increased serum IFN-γ levels and suppressed IL-4 levels on day 21 compared to pre-treatment levels (P&lt;0.05). Notably, the combination of cryoablation and GM-CSF significantly elevated the Th1/Th2 ratio (P&lt;0.05).Conclusion: Combining cryoablation with GM-CSF treatment holds promise for CLM management. It exhibits increased DC infiltration within the tumor microenvironment, enhanced immune responses, and prolonged survival in tumor-bearing mice.]]></abstract>
				<keyword_fa></keyword_fa>
				<keyword>Colorectal Neoplasms, cryosurgery, Cytokines, Dendritic cells, Granulocyte-macrophage - colony-stimulating factor, Immunity, Liver neoplasms, Tumor Microenvironment</keyword>
				<start_page>584</start_page>
				<end_page>591</end_page>
				<web_url>https://ijbms.mums.ac.ir/article_25490.html</web_url>
			<author_list><author>
				<first_name>Junfeng</first_name>
				<middle_name></middle_name>
				<last_name>Wang</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>drwjfeng@163.com</email>
				<code>111846</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Colorectal Cancer, Tianjin Medical University Cancer Institute and Hospital, Tianjin, 300060, China|National Clinical Research Center for Cancer, Tianjin, 300060, China|Tianjin Key Laboratory of Cancer Prevention and Therapy, Tianjin, 300060, China|Tianjin’s Clinical Research Center for Cancer, Tianjin, 300060, China</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Dalu</first_name>
				<middle_name></middle_name>
				<last_name>Kong</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>zlyyjzck@163.com</email>
				<code>111847</code>
				<coreauthor>Yes</coreauthor>
				<affiliation>Department of Colorectal Cancer, Tianjin Medical University Cancer Institute and Hospital, Tianjin, 300060, China|National Clinical Research Center for Cancer, Tianjin, 300060, China|Tianjin Key Laboratory of Cancer Prevention and Therapy, Tianjin, 300060, China|Tianjin’s Clinical Research Center for Cancer, Tianjin, 300060, China</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author></author_list>
				</article>
			</articleset>
			</journal>