<?xml version="1.0" encoding="utf-8"?>
			<journal>
			<title>Iranian Journal of Basic Medical Sciences</title>
			<title_fa></title_fa>
			<short_title></short_title>
			<subject>Medical Sciences</subject>
			<web_url>https://ijbms.mums.ac.ir/</web_url>
			<journal_hbi_system_id>0</journal_hbi_system_id>
			<journal_hbi_system_user></journal_hbi_system_user>
			<journal_id_issn>2008-3866</journal_id_issn>
			<journal_id_issn_online>2008-3874</journal_id_issn_online>
			<journal_id_pii></journal_id_pii>
			<journal_id_doi></journal_id_doi>
			<journal_id_iranmedex></journal_id_iranmedex>
			<journal_id_magiran></journal_id_magiran>
			<journal_id_sid></journal_id_sid>
			<journal_id_nlai></journal_id_nlai>
			<journal_id_science></journal_id_science>
			<language>en</language>
			<pubdate>
				<type>jalali</type>
				<year>2025</year>
				<month>6</month>
				<day>1</day>
			</pubdate>
			<pubdate>
				<type>gregorian</type>
				<year>2025</year>
				<month>6</month>
				<day>1</day>
			</pubdate>
			<volume>28</volume>
			<number>6</number>
			<publish_type>online</publish_type>
			<publish_edition>1</publish_edition>
			<article_type>fulltext</article_type>
			<articleset><article>
				<language>en</language>
				<article_id_issn></article_id_issn>
				<article_id_issn_online></article_id_issn_online>
				<article_id_pubmed></article_id_pubmed>
				<article_id_pii></article_id_pii>
				<article_id_doi></article_id_doi>
				<article_id_iranmedex></article_id_iranmedex>
				<article_id_magiran></article_id_magiran>
				<article_id_sid></article_id_sid>
				<title_fa></title_fa>
				<title>Effects and mechanism of puerarin on lactation of postpartum hypogalactia mice</title>
				<subject_fa></subject_fa>
				<subject></subject>
				<content_type_fa></content_type_fa>
				<content_type>Original Article</content_type>
				<abstract_fa><![CDATA[]]></abstract_fa>
				<abstract><![CDATA[Objective(s): Insufficient breast milk supply is a common reason cited for discontinuing breastfeeding prematurely. Natural galactagogues offer promise as a solution for mothers with low milk production. This study aimed to explore puerarin’s potential effects and underlying mechanism on lactation of postpartum hypogalactia mice.Materials and Methods: Postpartum mice were randomly assigned to five groups: control group, agalactosis model group, domperidone group (3.5 mg/kg), low dose puerarin group (18 mg/kg), and high dose puerarin group (72 mg/kg). The effects of puerarin on postpartum hypogalactia mice were evaluated by lactation indicators and pathological morphology. Related hormones and prolactin receptor (PRLR)/Janus kinase 2 (JAK2)/signal transduction and activator (STAT) 5 signaling pathway were also measured.Results: Puerarin significantly improved lactation yield and stimulated mammary gland development in postpartum hypogalactia mice. Additionally, puerarin increased the expression levels of β-casein, fatty acid synthase (FAS), and glucose transporter 1 (GLUT1). Mechanically, puerarin stimulated secretion of prolactin (PRL), estradiol (E2), and progesterone (P4) in agalactosis mice. Puerarin also substantially increased PRLR, JAK2, and STAT5a expression levels in postpartum hypogalactia mice. Conclusion: This study suggested that puerarin may promote lactation by stimulating PRL secretion and activating the PRLR/JAK2/STAT5 signaling pathway.]]></abstract>
				<keyword_fa></keyword_fa>
				<keyword>Breast Feeding, Domperidone, Galactogogues, Phytoestrogens, Prolactin</keyword>
				<start_page>739</start_page>
				<end_page>745</end_page>
				<web_url>https://ijbms.mums.ac.ir/article_25622.html</web_url>
			<author_list><author>
				<first_name>Ya-jie</first_name>
				<middle_name></middle_name>
				<last_name>Yang</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>yangyajie9511@163.com</email>
				<code>112442</code>
				<coreauthor>No</coreauthor>
				<affiliation>School of Chinese Medical, Beijing University of Chinese Medicine, Beijing, 102446, China</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Bing-qing</first_name>
				<middle_name></middle_name>
				<last_name>Liu</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>18801112764@163.com</email>
				<code>112443</code>
				<coreauthor>No</coreauthor>
				<affiliation>School of Chinese Medical, Beijing University of Chinese Medicine, Beijing, 102446, China</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Yang</first_name>
				<middle_name></middle_name>
				<last_name>Jiang</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>yjiang2010@163.com</email>
				<code>112444</code>
				<coreauthor>No</coreauthor>
				<affiliation>School of Chinese Medical, Beijing University of Chinese Medicine, Beijing, 102446, China</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Man-yu</first_name>
				<middle_name></middle_name>
				<last_name>Zhou</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>zhoumanyu_zmy@163.com</email>
				<code>112445</code>
				<coreauthor>No</coreauthor>
				<affiliation>School of Chinese Medical, Beijing University of Chinese Medicine, Beijing, 102446, China</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Re-yi-la</first_name>
				<middle_name></middle_name>
				<last_name>Tuerxun</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>reyila@bucm.edu.cn</email>
				<code>112446</code>
				<coreauthor>No</coreauthor>
				<affiliation>Traditional Chinese Medicine Hospital of Xinjiang Uyghur Autonomous Region, Xinjiang, 830092, China</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Hong-shuang</first_name>
				<middle_name></middle_name>
				<last_name>Liu</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>18811479932@163.com</email>
				<code>112447</code>
				<coreauthor>No</coreauthor>
				<affiliation>School of Chinese Medical, Beijing University of Chinese Medicine, Beijing, 102446, China</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Yan</first_name>
				<middle_name></middle_name>
				<last_name>Liao</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>liaoyanbucm@126.com</email>
				<code>112448</code>
				<coreauthor>Yes</coreauthor>
				<affiliation>School of Chinese Medical, Beijing University of Chinese Medicine, Beijing, 102446, China</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author></author_list>
				</article>
			</articleset>
			</journal>