<?xml version="1.0" encoding="utf-8"?>
			<journal>
			<title>Iranian Journal of Basic Medical Sciences</title>
			<title_fa></title_fa>
			<short_title></short_title>
			<subject>Medical Sciences</subject>
			<web_url>https://ijbms.mums.ac.ir/</web_url>
			<journal_hbi_system_id>0</journal_hbi_system_id>
			<journal_hbi_system_user></journal_hbi_system_user>
			<journal_id_issn>2008-3866</journal_id_issn>
			<journal_id_issn_online>2008-3874</journal_id_issn_online>
			<journal_id_pii></journal_id_pii>
			<journal_id_doi></journal_id_doi>
			<journal_id_iranmedex></journal_id_iranmedex>
			<journal_id_magiran></journal_id_magiran>
			<journal_id_sid></journal_id_sid>
			<journal_id_nlai></journal_id_nlai>
			<journal_id_science></journal_id_science>
			<language>en</language>
			<pubdate>
				<type>jalali</type>
				<year>2025</year>
				<month>7</month>
				<day>1</day>
			</pubdate>
			<pubdate>
				<type>gregorian</type>
				<year>2025</year>
				<month>7</month>
				<day>1</day>
			</pubdate>
			<volume>28</volume>
			<number>7</number>
			<publish_type>online</publish_type>
			<publish_edition>1</publish_edition>
			<article_type>fulltext</article_type>
			<articleset><article>
				<language>en</language>
				<article_id_issn></article_id_issn>
				<article_id_issn_online></article_id_issn_online>
				<article_id_pubmed></article_id_pubmed>
				<article_id_pii></article_id_pii>
				<article_id_doi></article_id_doi>
				<article_id_iranmedex></article_id_iranmedex>
				<article_id_magiran></article_id_magiran>
				<article_id_sid></article_id_sid>
				<title_fa></title_fa>
				<title>Thymoquinone prevents valproic acid-induced hepatotoxicity via modulation of cytochrome P450, PPARs, and apoptotic pathways</title>
				<subject_fa></subject_fa>
				<subject></subject>
				<content_type_fa></content_type_fa>
				<content_type>Original Article</content_type>
				<abstract_fa><![CDATA[]]></abstract_fa>
				<abstract><![CDATA[Objective(s): Thymoquinone (TQ) is the main bioactive component of Nigella sativa L. and has anti-oxidant, anti-hepatotoxic, anti-cancer, anti-hypertensive, hypoglycemic, anti-inflammatory, and lipid-lowering properties. In this study, we investigated the protective properties of TQ on the cytochrome P450 enzyme system, peroxisome proliferator-activated receptors, and gene expressions involved in apoptosis, which are disrupted by valproic acid (VPA). Materials and Methods: The rats were put into control, VPA, and VPA+TQ groups. The weight of the body and liver were recorded. Liver tissue samples were evaluated for gene expressions (Bcl-2, p53, CYP2B1, CYP2B2, PPARα, and PPARγ), histopatology, and immunohistochemistry (CAS-3 and NOX-4). Additionally, serum was used to measure liver function parameters (ALT, AST, LDH, LDL, and HDL). Results: The VPA+TQ group had significantly lower expression of p53 (P&lt;0.05), CYP2B1 (P&lt;0.05), CYP2B2 (P&lt;0.05), PPARα (P&lt;0.05), and PPARγ (P&lt;0.05) genes compared to the VPA groups, while Bcl-2 (P&lt;0.05) gene expression increased. TQ decreased CAS-3 and NOX-4 levels. Also, TQ reduced ALT (P&lt;0.05), AST (P&lt;0.05), LDL (P&lt;0.01), total bilirubin (P&lt;0.05), and LDH (P&lt;0.05) enzyme activity while increasing HDL (P&lt;0.0001). TQ treatment improved fresh liver weight considerably (P&lt;0.0001). Conclusion: TQ substantially protects liver tissue by modifying gene expression, lowering oxidative stress, and increasing liver function. It significantly counteracts VPA’s toxic effects, demonstrating its promise as a hepatoprotective agent in avoiding liver damage. ]]></abstract>
				<keyword_fa></keyword_fa>
				<keyword>Apoptosis, Cytochromes, Liver, Oxidative stress, PPAR, Thymoquinone, Valproic acid</keyword>
				<start_page>899</start_page>
				<end_page>906</end_page>
				<web_url>https://ijbms.mums.ac.ir/article_25893.html</web_url>
			<author_list><author>
				<first_name>Sebile</first_name>
				<middle_name></middle_name>
				<last_name>Azirak</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>sazirak@adiyaman.edu.tr</email>
				<code>113594</code>
				<coreauthor>Yes</coreauthor>
				<affiliation>University of Adiyaman, Vocational School of Health Services, Adiyaman, Turkey</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Sedat</first_name>
				<middle_name></middle_name>
				<last_name>Bilgiç</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>sbilgic@adiyaman.edu.tr</email>
				<code>113595</code>
				<coreauthor>No</coreauthor>
				<affiliation>University of Adiyaman, Vocational School of Health Services, Adiyaman, Turkey</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Deniz</first_name>
				<middle_name>Taştemir</middle_name>
				<last_name>Korkmaz</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>dtastemir@adiyaman.edu.tr</email>
				<code>113596</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Medical Biology, Faculty of Medicine, Adiyaman University, Adiyaman, Turkey</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>İlkay</first_name>
				<middle_name></middle_name>
				<last_name>Armağan</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>ilkayarmagan@sdu.edu.tr</email>
				<code>113597</code>
				<coreauthor>No</coreauthor>
				<affiliation>University of Suleyman Demirel, Department of Histology and Embryology, Faculty of Medicine, Isparta, Turkey</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Mehmet Kaya</first_name>
				<middle_name></middle_name>
				<last_name>Özer</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>mkayaozer@adiyaman.edu.tr</email>
				<code>113598</code>
				<coreauthor>No</coreauthor>
				<affiliation>University of Adiyaman, Department of Pharmacology, Faculty of Medicine, Adiyaman, Turkey</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author></author_list>
				</article>
			</articleset>
			</journal>