<?xml version="1.0" encoding="utf-8"?>
			<journal>
			<title>Iranian Journal of Basic Medical Sciences</title>
			<title_fa></title_fa>
			<short_title></short_title>
			<subject>Medical Sciences</subject>
			<web_url>https://ijbms.mums.ac.ir/</web_url>
			<journal_hbi_system_id>0</journal_hbi_system_id>
			<journal_hbi_system_user></journal_hbi_system_user>
			<journal_id_issn>2008-3866</journal_id_issn>
			<journal_id_issn_online>2008-3874</journal_id_issn_online>
			<journal_id_pii></journal_id_pii>
			<journal_id_doi></journal_id_doi>
			<journal_id_iranmedex></journal_id_iranmedex>
			<journal_id_magiran></journal_id_magiran>
			<journal_id_sid></journal_id_sid>
			<journal_id_nlai></journal_id_nlai>
			<journal_id_science></journal_id_science>
			<language>en</language>
			<pubdate>
				<type>jalali</type>
				<year>2025</year>
				<month>10</month>
				<day>1</day>
			</pubdate>
			<pubdate>
				<type>gregorian</type>
				<year>2025</year>
				<month>10</month>
				<day>1</day>
			</pubdate>
			<volume>28</volume>
			<number>10</number>
			<publish_type>online</publish_type>
			<publish_edition>1</publish_edition>
			<article_type>fulltext</article_type>
			<articleset><article>
				<language>en</language>
				<article_id_issn></article_id_issn>
				<article_id_issn_online></article_id_issn_online>
				<article_id_pubmed></article_id_pubmed>
				<article_id_pii></article_id_pii>
				<article_id_doi></article_id_doi>
				<article_id_iranmedex></article_id_iranmedex>
				<article_id_magiran></article_id_magiran>
				<article_id_sid></article_id_sid>
				<title_fa></title_fa>
				<title>Expressions of apoptotic protein and gene following sulfur mustard-induced acute pulmonary injuries in rats</title>
				<subject_fa></subject_fa>
				<subject></subject>
				<content_type_fa></content_type_fa>
				<content_type>Original Article</content_type>
				<abstract_fa><![CDATA[]]></abstract_fa>
				<abstract><![CDATA[Objective(s): Pathomechanisms of sulfur mustard (SM) are not fully understood, and no specific medical countermeasures exist to prevent SM-induced pulmonary injury. This study aimed to evaluate the apoptosis following SM-induced acute pulmonary injury.Materials and Methods: Acute pulmonary injury models were established using SM at an equivalent toxicity dose (1 LD50), administered via intraperitoneal injection or intratracheal instillation. Protein expression levels and mRNA expressions of apoptosis-related markers, including cellular inhibitor of apoptosis proteins-1 and -2 (cIAP-1, cIAP-2), Fas, Bcl-2-associated death promoter (Bad), second mitochondria-derived activator of caspases (Smac), and survivin (BIRC5), were analyzed using immunohistochemistry and polymerase chain reaction. Results: The intraperitoneal SM group exhibited significantly higher levels of apoptotic cells in the alveolar septa and increased protein and mRNA expression of cIAP-1, cIAP-2, Fas, Bad, Smac, and BIRC5 compared to the intratracheal SM group. These changes displayed a time-dependent increase in both protein and gene expression levels. Conclusion: SM-induced pulmonary injury involves both extrinsic (Fas, cIAP-1, cIAP-2) and intrinsic (Bad, Smac) pathways as well as caspase-dependent pathways (BIRC5). These findings provide valuable insights into the underlying mechanisms of SM toxicity and may facilitate the development of targeted therapeutic strategies.]]></abstract>
				<keyword_fa></keyword_fa>
				<keyword>Animals, Apoptosis, immunohistochemistry, Lung injury, Mustard Gas, Polymerase chain reaction</keyword>
				<start_page>1372</start_page>
				<end_page>1380</end_page>
				<web_url>https://ijbms.mums.ac.ir/article_26322.html</web_url>
			<author_list><author>
				<first_name>Tao</first_name>
				<middle_name></middle_name>
				<last_name>Liu</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>ltt2008l@163.com</email>
				<code>115539</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Respiration, the 80th Group Army Hospital of People’s Liberation Army, Weifang, 261021, China</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Jingtong</first_name>
				<middle_name></middle_name>
				<last_name>Li</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>lijingt@163.com</email>
				<code>115540</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Respiration, the 80th Group Army Hospital of People’s Liberation Army, Weifang, 261021, China</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Xiaoxuan</first_name>
				<middle_name></middle_name>
				<last_name>Hu</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>hxxdr@sina.com</email>
				<code>115541</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Pulmonary and Critical Care Medicine, Weifang No. 2 People’s Hospital, Weifang Respiratory Disease Hospital, Weifang, 261041, China|State Key Laboratory of Antitoxic Drugs and Toxicology, Institute of Toxicology and Pharmacology, Academy of Military Medical Sciences, Beijing, 100850, China</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Jinyuan</first_name>
				<middle_name></middle_name>
				<last_name>Tang</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>hnmrtjy981@163.com</email>
				<code>115542</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Respiration, the 80th Group Army Hospital of People’s Liberation Army, Weifang, 261021, China</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Yuxu</first_name>
				<middle_name></middle_name>
				<last_name>Zhong</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>yuxuzhong2008@aliyun.com</email>
				<code>115543</code>
				<coreauthor>No</coreauthor>
				<affiliation>State Key Laboratory of Antitoxic Drugs and Toxicology, Institute of Toxicology and Pharmacology, Academy of Military Medical Sciences, Beijing, 100850, China</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Xin</first_name>
				<middle_name></middle_name>
				<last_name>Shu</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>dr_shuxin@sina.com</email>
				<code>115544</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Dermatology, The Third Medical Center of Chinese PLA General Hospital, Beijing, 100039, China</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Xiao-ji</first_name>
				<middle_name></middle_name>
				<last_name>Zhu</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>xiaojizhu@163.com</email>
				<code>115538</code>
				<coreauthor>Yes</coreauthor>
				<affiliation>Department of Respiration, the 80th Group Army Hospital of People’s Liberation Army, Weifang, 261021, China</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author></author_list>
				</article>
			</articleset>
			</journal>