<?xml version="1.0" encoding="utf-8"?>
			<journal>
			<title>Iranian Journal of Basic Medical Sciences</title>
			<title_fa></title_fa>
			<short_title></short_title>
			<subject>Medical Sciences</subject>
			<web_url>https://ijbms.mums.ac.ir/</web_url>
			<journal_hbi_system_id>0</journal_hbi_system_id>
			<journal_hbi_system_user></journal_hbi_system_user>
			<journal_id_issn>2008-3866</journal_id_issn>
			<journal_id_issn_online>2008-3874</journal_id_issn_online>
			<journal_id_pii></journal_id_pii>
			<journal_id_doi></journal_id_doi>
			<journal_id_iranmedex></journal_id_iranmedex>
			<journal_id_magiran></journal_id_magiran>
			<journal_id_sid></journal_id_sid>
			<journal_id_nlai></journal_id_nlai>
			<journal_id_science></journal_id_science>
			<language>en</language>
			<pubdate>
				<type>jalali</type>
				<year>2026</year>
				<month>2</month>
				<day>1</day>
			</pubdate>
			<pubdate>
				<type>gregorian</type>
				<year>2026</year>
				<month>2</month>
				<day>1</day>
			</pubdate>
			<volume>29</volume>
			<number>2</number>
			<publish_type>online</publish_type>
			<publish_edition>1</publish_edition>
			<article_type>fulltext</article_type>
			<articleset><article>
				<language>en</language>
				<article_id_issn></article_id_issn>
				<article_id_issn_online></article_id_issn_online>
				<article_id_pubmed></article_id_pubmed>
				<article_id_pii></article_id_pii>
				<article_id_doi></article_id_doi>
				<article_id_iranmedex></article_id_iranmedex>
				<article_id_magiran></article_id_magiran>
				<article_id_sid></article_id_sid>
				<title_fa></title_fa>
				<title>Syringic acid attenuates LPS-induced acute lung injury via modulation of the HMGB1/TLR4/NF-κB and Keap1/Nrf2/HO-1 pathways: Mechanistic insights from in vivo and in silico studies</title>
				<subject_fa></subject_fa>
				<subject></subject>
				<content_type_fa></content_type_fa>
				<content_type>Original Article</content_type>
				<abstract_fa><![CDATA[]]></abstract_fa>
				<abstract><![CDATA[Objective(s): Sepsis-induced acute lung injury (ALI), driven by uncontrolled inflammation and oxidative stress, remains a major cause of mortality in critically ill patients. This study aimed to investigate the protective and mechanistic effects of syringic acid (SA), a natural phenolic compound, against lipopolysaccharide (LPS)-induced ALI in rats.Materials and Methods: Male Sprague–Dawley rats were allocated into five groups: control, SA80, LPS, SA40+LPS, and SA80+LPS. SA was orally administered (40 or 80 mg/kg/day) for 14 days before a single intraperitoneal injection of LPS (10 mg/kg). Lung tissues were collected 12 hr post-LPS for histopathological, biochemical, and molecular evaluations. In silico docking using Schrödinger Maestro (2025/1) assessed SA interaction with the KEAP1 Kelch domain (PDB: 5FZN).Results: LPS challenge caused severe pulmonary edema, inflammatory infiltration, elevated proinflammatory cytokines, lipid peroxidation, and reduced antioxidant enzyme activities. SA pretreatment, particularly at 80 mg/kg, significantly (P&lt;0.05) alleviated these alterations. Mechanistically, SA down-regulated the HMGB1/TLR4/NF-κB signaling cascade and activated the Keap1/Nrf2/HO-1 antioxidant pathway. Reduced 8-OHdG and caspase-3 expression indicated mitigation of oxidative DNA damage and apoptosis. Docking analysis revealed strong binding affinity and favorable MM-GBSA scores for SA within the KEAP1 active pocket, suggesting direct modulation of Nrf2 activation.Conclusion: SA confers potent protection against LPS-induced ALI through coordinated anti-inflammatory and antioxidant mechanisms involving HMGB1/TLR4/NF-κB inhibition and Keap1/Nrf2/HO-1 activation. These findings highlight SA as a promising therapeutic candidate for sepsis-associated pulmonary injury.]]></abstract>
				<keyword_fa></keyword_fa>
				<keyword>Acute lung injury, Inflammation, Lipopolysaccharide, NF-kappa B, Oxidative stress, Phenols</keyword>
				<start_page>302</start_page>
				<end_page>312</end_page>
				<web_url>https://ijbms.mums.ac.ir/article_27297.html</web_url>
			<author_list><author>
				<first_name>Burak</first_name>
				<middle_name>Batuhan</middle_name>
				<last_name>Lacin</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>bblacin@atauni.edu.tr</email>
				<code>119860</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Physiology, Faculty of Veterinary Medicine, Ataturk University, Erzurum, Turkey</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Emin</first_name>
				<middle_name></middle_name>
				<last_name>Şengul</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>emin.sengul@atauni.edu.tr</email>
				<code>119861</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Physiology, Faculty of Veterinary Medicine, Ataturk University, Erzurum, Turkey|Department of Pharmacology, Faculty of Medicine, Atatürk University, Erzurum, Turkey</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Serkan</first_name>
				<middle_name></middle_name>
				<last_name>Yildirim</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>syildirim@atauni.edu.tr</email>
				<code>119862</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Pathology, Faculty of Veterinary Medicine, Ataturk University, Erzurum, Turkey|Department of Pathology, Faculty of Veterinary Medicine, Kyrgyzstan-Turkey Manas University, Bishkek, Kyrgyzstan</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Furkan</first_name>
				<middle_name></middle_name>
				<last_name>Aykurt</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>aykurtfurkan6161@gmail.com</email>
				<code>119863</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Physiology, Faculty of Veterinary Medicine, Ataturk University, Erzurum, Turkey</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Mohamad</first_name>
				<middle_name></middle_name>
				<last_name>Warda</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>mohamad.warda@atauni.edu.tr</email>
				<code>119864</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Physiology, Faculty of Veterinary Medicine, Ataturk University, Erzurum, Turkey|Department of Biochemistry, Faculty of Veterinary Medicine, Cairo University, Giza, Egypt</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Burak</first_name>
				<middle_name></middle_name>
				<last_name>Cinar</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>burak.cinar@atauni.edu.tr</email>
				<code>119865</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Pharmacology, Faculty of Medicine, Atatürk University, Erzurum, Turkey</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Ali</first_name>
				<middle_name></middle_name>
				<last_name>Cinar</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>d.cinar@atauni.edu.tr</email>
				<code>119866</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Physiology, Faculty of Veterinary Medicine, Ataturk University, Erzurum, Turkey</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author></author_list>
				</article>
			</articleset>
			</journal>