<?xml version="1.0" encoding="utf-8"?>
			<journal>
			<title>Iranian Journal of Basic Medical Sciences</title>
			<title_fa></title_fa>
			<short_title></short_title>
			<subject>Medical Sciences</subject>
			<web_url>https://ijbms.mums.ac.ir/</web_url>
			<journal_hbi_system_id>0</journal_hbi_system_id>
			<journal_hbi_system_user></journal_hbi_system_user>
			<journal_id_issn>2008-3866</journal_id_issn>
			<journal_id_issn_online>2008-3874</journal_id_issn_online>
			<journal_id_pii></journal_id_pii>
			<journal_id_doi></journal_id_doi>
			<journal_id_iranmedex></journal_id_iranmedex>
			<journal_id_magiran></journal_id_magiran>
			<journal_id_sid></journal_id_sid>
			<journal_id_nlai></journal_id_nlai>
			<journal_id_science></journal_id_science>
			<language>en</language>
			<pubdate>
				<type>jalali</type>
				<year>2026</year>
				<month>6</month>
				<day>1</day>
			</pubdate>
			<pubdate>
				<type>gregorian</type>
				<year>2026</year>
				<month>6</month>
				<day>1</day>
			</pubdate>
			<volume>29</volume>
			<number>6</number>
			<publish_type>online</publish_type>
			<publish_edition>1</publish_edition>
			<article_type>fulltext</article_type>
			<articleset><article>
				<language>en</language>
				<article_id_issn></article_id_issn>
				<article_id_issn_online></article_id_issn_online>
				<article_id_pubmed></article_id_pubmed>
				<article_id_pii></article_id_pii>
				<article_id_doi></article_id_doi>
				<article_id_iranmedex></article_id_iranmedex>
				<article_id_magiran></article_id_magiran>
				<article_id_sid></article_id_sid>
				<title_fa></title_fa>
				<title>AI-driven CRISPR strategies in breast cancer: Organoid modeling, adaptive editing, and precision delivery</title>
				<subject_fa></subject_fa>
				<subject></subject>
				<content_type_fa></content_type_fa>
				<content_type>Review Article</content_type>
				<abstract_fa><![CDATA[]]></abstract_fa>
				<abstract><![CDATA[Triple-negative breast cancer (TNBC) is defined by profound heterogeneity, dormant metastatic reservoirs, and rapid therapy resistance. Building on our AI-Driven CRISPR Strategies in Breast Cancer framework, CRISPR–Cas9 is emerging as more than a gene-editing tool, capable of restoring circadian integrity, eliminating dormant clones, and re-programming immune surveillance. A structured PubMed, Scopus, and ClinicalTrials.gov review through 2025 integrated mechanistic, preclinical, and early clinical evidence. Beyond standard knockout, base, and prime editing, we highlight chrono-genomic repair of BMAL1/PER2, dormancy-focused synthetic-lethality screens, and genomic-collapse tactics for BRCA1-deficient tumors. Adaptive AI pipelines that iteratively refine guide RNAs and exosome-mimetic carriers, incorporating Boolean logic gates, were also evaluated for self-regulated, tumor-specific delivery. Proof-of-concept studies show that HER2 deletion, TP53 rescue, and ABCB1 silencing enhance chemosensitivity across luminal, HER2-positive, and TNBC models. Circadian restoration expands therapeutic windows and delays relapse in xenografts. Dormancy-directed CRISPR screens reveal unique vulnerabilities in disseminated tumor cells, whereas genomic collapse selectively destroys BRCA1-mutant clones. Integration with CAR-T cells and antibody–drug conjugates amplifies cytotoxicity, and transient nanoparticle or exosome systems improve solid-tumor penetration while minimizing off-target events. CRISPR–Cas9 is transitioning from a molecular scalpel to an adaptive, self-learning therapeutic ecosystem. By uniting AI-guided design, circadian reprogramming, dormancy eradication, and logic-gated delivery, the strategies detailed here define a next-generation precision-oncology paradigm capable of anticipating tumor evolution, overcoming resistance, and preventing metastatic relapse.]]></abstract>
				<keyword_fa></keyword_fa>
				<keyword>Artificial intelligence, Breast neoplasms, Circadian Rhythm, CRISPR-Cas systems, Gene editing, Gene knockout techniques, Neoplasm dormancy, Triple negative breast- neoplasms</keyword>
				<start_page>823</start_page>
				<end_page>843</end_page>
				<web_url>https://ijbms.mums.ac.ir/article_27615.html</web_url>
			<author_list><author>
				<first_name>Anmar</first_name>
				<middle_name>Ghanim</middle_name>
				<last_name>Taki</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>ammar.ghanim2000@gmail.com</email>
				<code>121289</code>
				<coreauthor>Yes</coreauthor>
				<affiliation>Department of Radiology Techniques, Health and Medical Techniques College, Alnoor University, Nineveh, Iraq</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Abdulkareem</first_name>
				<middle_name></middle_name>
				<last_name>Shareef</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>abdulkareem.shareef@abu.edu.iq</email>
				<code>121290</code>
				<coreauthor>No</coreauthor>
				<affiliation>Ahl al bayt University, Kerbala, Iraq</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Vimal</first_name>
				<middle_name></middle_name>
				<last_name>Arora</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>drvimalarora1@outlook.com</email>
				<code>121291</code>
				<coreauthor>No</coreauthor>
				<affiliation>University institute of Pharma Sciences, Chandigarh University, Mohali, Punjab, India</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Rami</first_name>
				<middle_name></middle_name>
				<last_name>Oweis</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>rami.oweis@mcbs.edu.om</email>
				<code>121292</code>
				<coreauthor>No</coreauthor>
				<affiliation>Modern College of Business and Science, Muscat, Oman|On sabbatical leave, from Jordan University of Science and Technology, Irbid, Jordan</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>S. Renuka</first_name>
				<middle_name></middle_name>
				<last_name>Jyothi</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>j.renuka@jainuniversity.ac.in</email>
				<code>121293</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Biotechnology and Genetics, School of Sciences, JAIN (Deemed to be University), Bangalore, Karnataka, India</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Udaybir</first_name>
				<middle_name></middle_name>
				<last_name>Singh</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>udaybirsingh0202@outlook.com</email>
				<code>121294</code>
				<coreauthor>No</coreauthor>
				<affiliation>Center for Research Impact &amp; Outcome, Chitkara University Institute of Engineering and Technology, Chitkara University, Rajpura, 140401, Punjab, India</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Samir</first_name>
				<middle_name></middle_name>
				<last_name>Sahoo</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>samirsahu@soa.ac.in</email>
				<code>121295</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of General Medicine, IMS and SUM Hospital, Siksha ‘O’ Anusandhan (Deemed to be University), Bhubaneswar, Odisha-751003, India</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Ashish</first_name>
				<middle_name>Singh</middle_name>
				<last_name>Chauhan</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>ashishchauhan.pharmacy@gmail.com</email>
				<code>121296</code>
				<coreauthor>No</coreauthor>
				<affiliation>Uttaranchal Institute of Pharmaceutical Sciences, Division of Research and Innovation, Uttaranchal University, Dehradun, Uttarakhand, India</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Guzal</first_name>
				<middle_name></middle_name>
				<last_name>Klebleeva</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>laylo.djuraeva.88@bk.ru</email>
				<code>121297</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Skin and Venereal Diseases, Samarkand State Medical University, Samarkand, Uzbekistan</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Hayder</first_name>
				<middle_name>Naji</middle_name>
				<last_name>Sameer</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>hayder.sam@nust.edu.iq</email>
				<code>121298</code>
				<coreauthor>No</coreauthor>
				<affiliation>Collage of Pharmacy, National University of Science and Technology, Dhi Qar, 64001, Iraq</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Ahmed</first_name>
				<middle_name></middle_name>
				<last_name>Yaseen</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>ahmed.yaseen.alsharea@gau.edu.iq</email>
				<code>121299</code>
				<coreauthor>No</coreauthor>
				<affiliation>Gilgamesh Ahliya University, Baghdad, Iraq</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Zainab</first_name>
				<middle_name></middle_name>
				<last_name>H. Athab</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>zainb@g.alzahu.edu.iq</email>
				<code>121300</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Pharmacy, Al-Zahrawi University College, Karbala, Iraq</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Mohaned</first_name>
				<middle_name></middle_name>
				<last_name>Adil</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>mariamkh681@gmail.com</email>
				<code>121301</code>
				<coreauthor>No</coreauthor>
				<affiliation>Pharmacy college, Al-Farahidi University, Baghdad, Iraq</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author></author_list>
				</article>
			</articleset>
			</journal>