<?xml version="1.0" encoding="utf-8"?>
			<journal>
			<title>Iranian Journal of Basic Medical Sciences</title>
			<title_fa></title_fa>
			<short_title></short_title>
			<subject>Medical Sciences</subject>
			<web_url>https://ijbms.mums.ac.ir/</web_url>
			<journal_hbi_system_id>0</journal_hbi_system_id>
			<journal_hbi_system_user></journal_hbi_system_user>
			<journal_id_issn>2008-3866</journal_id_issn>
			<journal_id_issn_online>2008-3874</journal_id_issn_online>
			<journal_id_pii></journal_id_pii>
			<journal_id_doi></journal_id_doi>
			<journal_id_iranmedex></journal_id_iranmedex>
			<journal_id_magiran></journal_id_magiran>
			<journal_id_sid></journal_id_sid>
			<journal_id_nlai></journal_id_nlai>
			<journal_id_science></journal_id_science>
			<language>en</language>
			<pubdate>
				<type>jalali</type>
				<year>2026</year>
				<month>6</month>
				<day>1</day>
			</pubdate>
			<pubdate>
				<type>gregorian</type>
				<year>2026</year>
				<month>6</month>
				<day>1</day>
			</pubdate>
			<volume>29</volume>
			<number>6</number>
			<publish_type>online</publish_type>
			<publish_edition>1</publish_edition>
			<article_type>fulltext</article_type>
			<articleset><article>
				<language>en</language>
				<article_id_issn></article_id_issn>
				<article_id_issn_online></article_id_issn_online>
				<article_id_pubmed></article_id_pubmed>
				<article_id_pii></article_id_pii>
				<article_id_doi></article_id_doi>
				<article_id_iranmedex></article_id_iranmedex>
				<article_id_magiran></article_id_magiran>
				<article_id_sid></article_id_sid>
				<title_fa></title_fa>
				<title>Hepatoprotective effect of hUC-MSC secretome in LPS-induced HepG2 cells</title>
				<subject_fa></subject_fa>
				<subject></subject>
				<content_type_fa></content_type_fa>
				<content_type>Original Article</content_type>
				<abstract_fa><![CDATA[]]></abstract_fa>
				<abstract><![CDATA[Objective(s): This study aimed to evaluate the cytotoxicity and hepatoprotective effects of human umbilical cord mesenchymal stem cell–derived secretome (hUCMSC-Sec) in lipopolysaccharide (LPS)-induced HepG2 cells as an in vitro model of liver inflammation.Materials and Methods: hUCMSC-Sec was obtained from conditioned media of hUCMSCs at passage four. Inflammation was induced in HepG2 cells using LPS. Cytotoxicity was assessed using the WST-8 assay. Hepatoprotective effects of hUCMSC-Sec at concentrations of 12.5%, 4.17%, and 1.39% were evaluated by measuring alanine aminotransferase (ALT), aspartate aminotransferase (AST), γ-glutamyl transferase (GGT), and tumor necrosis factor-alpha (TNF-α). Gene expression levels of α-smooth muscle actin (α-SMA), SMAD-7, collagen type I alpha 1 (COL1A1), and matrix metalloproteinase-1 (MMP-1) were analyzed using quantitative real-time PCR.Results: hUCMSC-Sec concentrations ranging from 1.6% to 25% were non-toxic, maintaining cell viability above 90%. Treatment with hUCMSC-Sec significantly reduced ALT, AST, GGT, and TNF-α levels in LPS-induced HepG2 cells. In addition, hUCMSC-Sec down-regulated α-SMA, COL1A1, and MMP-1 expression, while up-regulating SMAD-7 expression. The concentration of 4.17% showed the most pronounced hepatoprotective effect.Conclusion: hUCMSC-derived secretome demonstrated hepatoprotective effects by attenuating inflammatory and fibrotic responses in LPS-induced HepG2 cells. However, as this study was limited to an in vitro model, further in vivo and clinical studies are required to confirm its therapeutic potential and translational applicability.  ]]></abstract>
				<keyword_fa></keyword_fa>
				<keyword>Fibrosis, Inflammation, Protective agent, Secretome, Umbilical cord</keyword>
				<start_page>901</start_page>
				<end_page>908</end_page>
				<web_url>https://ijbms.mums.ac.ir/article_27688.html</web_url>
			<author_list><author>
				<first_name>Wahyu</first_name>
				<middle_name></middle_name>
				<last_name>Widowati</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>wahyu_w60@yahoo.com</email>
				<code>121598</code>
				<coreauthor>Yes</coreauthor>
				<affiliation>Faculty of Medicine, Maranatha Christian University, Bandung 40164, West Java, Indonesia</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Philips</first_name>
				<middle_name></middle_name>
				<last_name>Onggowidjaja</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>philips.onggowidjaja@yahoo.com</email>
				<code>121599</code>
				<coreauthor>No</coreauthor>
				<affiliation>Faculty of Medicine, Maranatha Christian University, Bandung 40164, West Java, Indonesia</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Massoud</first_name>
				<middle_name></middle_name>
				<last_name>Vosough</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>masvos@yahoo.com</email>
				<code>121600</code>
				<coreauthor>No</coreauthor>
				<affiliation>Molecular Medicine Department, Biotechnology Research Center (BRC), Pasteur Institute of Iran, Tehran, Iran|Department of Regenerative Medicine, Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, Tehran, Iran|Experimental Cancer Medicine, Institution for Laboratory Medicine, and Karolinska University Hospital, Karolinska Institute, Stockholm, Sweden</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Dwi Nur</first_name>
				<middle_name></middle_name>
				<last_name>Triharsiwi</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>dwinur@amubbrc.co.id</email>
				<code>121601</code>
				<coreauthor>No</coreauthor>
				<affiliation>Biomolecular and Biomedical Research Center, Aretha Medika Utama, Bandung 40163 West Java, Indonesia</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Anindita Putri</first_name>
				<middle_name></middle_name>
				<last_name>Distya</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>aninditaputri@amubbrc.co.id</email>
				<code>121602</code>
				<coreauthor>No</coreauthor>
				<affiliation>Biomolecular and Biomedical Research Center, Aretha Medika Utama, Bandung 40163 West Java, Indonesia</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Lisna Wahyu</first_name>
				<middle_name></middle_name>
				<last_name>Nurani</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>lisnawahyunurani@upi.edu</email>
				<code>121604</code>
				<coreauthor>No</coreauthor>
				<affiliation>Departement of Biology, Faculty of Mathematics and Natural Science Universitas Pendidikan Indonesia, Bandung 40154, West Java, Indonesia</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Ismia</first_name>
				<middle_name></middle_name>
				<last_name>Rahmawati</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>is.ismia.rahma27@gmail.com</email>
				<code>121605</code>
				<coreauthor>No</coreauthor>
				<affiliation>Departement of Biology, Faculty of Mathematics and Natural Science Universitas Pendidikan Indonesia, Bandung 40154, West Java, Indonesia</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Any</first_name>
				<middle_name></middle_name>
				<last_name>Aryani</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>any_aryani@upi.edu</email>
				<code>121606</code>
				<coreauthor>No</coreauthor>
				<affiliation>Departement of Biology, Faculty of Mathematics and Natural Science Universitas Pendidikan Indonesia, Bandung 40154, West Java, Indonesia</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Didik</first_name>
				<middle_name></middle_name>
				<last_name>Priyandoko</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>didikpriyandoko@upi.edu</email>
				<code>121607</code>
				<coreauthor>No</coreauthor>
				<affiliation>Departement of Biology, Faculty of Mathematics and Natural Science Universitas Pendidikan Indonesia, Bandung 40154, West Java, Indonesia</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Rizal</first_name>
				<middle_name></middle_name>
				<last_name>Azis</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>rizal@eng.ui.ac.id</email>
				<code>121608</code>
				<coreauthor>No</coreauthor>
				<affiliation>Biomolecular and Biomedical Research Center, Aretha Medika Utama, Bandung 40163 West Java, Indonesia|Biomedical Engineering, Department of Electrical Engineering, Faculty of Engineering, Universitas Indonesia, Depok 16425, West Java, Indonesia</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Dhanar Septyawan</first_name>
				<middle_name></middle_name>
				<last_name>Hadiprasetyo</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>dhanar3095@gmail.com</email>
				<code>121609</code>
				<coreauthor>No</coreauthor>
				<affiliation>Biomolecular and Biomedical Research Center, Aretha Medika Utama, Bandung 40163 West Java, Indonesia|Faculty of Pharmacy, Universitas Jenderal Achmad Yani, Cimahi 40531, West Java, Indonesia</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Priyatharsini</first_name>
				<middle_name></middle_name>
				<last_name>Rajendran</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>priyatharsinirajendran@ldc.edu.in</email>
				<code>121610</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Zoology and Research Centre, Lady Doak College Madurai, India</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Kasim Sakran</first_name>
				<middle_name></middle_name>
				<last_name>Abass</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>kasim_abass@uokirkuk.edu.iq</email>
				<code>121611</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Physiology, Biochemistry, and Pharmacology; College of Veterinary Medicine, University of Kirkuk, Kirkuk 36001, Iraq</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Safira Dinda</first_name>
				<middle_name></middle_name>
				<last_name>Rifana</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>safiiradinda@gmail.com</email>
				<code>121603</code>
				<coreauthor>No</coreauthor>
				<affiliation>Biomolecular and Biomedical Research Center, Aretha Medika Utama, Bandung 40163 West Java, Indonesia</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author></author_list>
				</article>
			</articleset>
			</journal>