<?xml version="1.0" encoding="utf-8"?>
			<journal>
			<title>Iranian Journal of Basic Medical Sciences</title>
			<title_fa></title_fa>
			<short_title></short_title>
			<subject>Medical Sciences</subject>
			<web_url>https://ijbms.mums.ac.ir/</web_url>
			<journal_hbi_system_id>0</journal_hbi_system_id>
			<journal_hbi_system_user></journal_hbi_system_user>
			<journal_id_issn>2008-3866</journal_id_issn>
			<journal_id_issn_online>2008-3874</journal_id_issn_online>
			<journal_id_pii></journal_id_pii>
			<journal_id_doi></journal_id_doi>
			<journal_id_iranmedex></journal_id_iranmedex>
			<journal_id_magiran></journal_id_magiran>
			<journal_id_sid></journal_id_sid>
			<journal_id_nlai></journal_id_nlai>
			<journal_id_science></journal_id_science>
			<language>en</language>
			<pubdate>
				<type>jalali</type>
				<year>2026</year>
				<month>7</month>
				<day>1</day>
			</pubdate>
			<pubdate>
				<type>gregorian</type>
				<year>2026</year>
				<month>7</month>
				<day>1</day>
			</pubdate>
			<volume>29</volume>
			<number>7</number>
			<publish_type>online</publish_type>
			<publish_edition>1</publish_edition>
			<article_type>fulltext</article_type>
			<articleset><article>
				<language>en</language>
				<article_id_issn></article_id_issn>
				<article_id_issn_online></article_id_issn_online>
				<article_id_pubmed></article_id_pubmed>
				<article_id_pii></article_id_pii>
				<article_id_doi></article_id_doi>
				<article_id_iranmedex></article_id_iranmedex>
				<article_id_magiran></article_id_magiran>
				<article_id_sid></article_id_sid>
				<title_fa></title_fa>
				<title>Synergistic myelin regenerative, immunomodulatory and anti-inflammatory effects of vanillin and adipose derived stem cells in cuprizone animal model of multiple sclerosis</title>
				<subject_fa></subject_fa>
				<subject></subject>
				<content_type_fa></content_type_fa>
				<content_type>Original Article</content_type>
				<abstract_fa><![CDATA[]]></abstract_fa>
				<abstract><![CDATA[Objective(s): Vanillin as a potential therapeutic agent along with transplantation of neurotrophic factors secreting cells, is considered a promising treatment for neurological disorders. In this study, the effects of vanillin in combination with human adipose derived stem cells transplantation were evaluated on oligodendrocyte differentiation, re-myelination, and motor function improvement.Materials and Methods: Female C57BL/6 mice were fed cuprizone (400 mg/kg/day) for 5 weeks to induce MS. Demyelinated mice were divided into MS, MS/vanillin, MS/stem cells, and MS/vanillin/stem cells groups. Additionally, sixteen mice were divided into control and sham groups for comparison. Motor function was assessed using the hanging wire test. Finally, serum levels of inflammatory (IL-2, IFN-γ) and anti-inflammatory (IL-10, TGF-β) factors, along with IgG, were measured by ELISA. The mean percentage of Olig2 and MOG-positive cells we determined using the immunohistochemical technique, and Luxal Fast Blue staining was performed to assess myelin density of corpus callosum.Results: The results revealed that the mean percentage of Olig2, Mog positive cells, the serum level of the IL-10 and TGF-β, myelin density, and behavior test score were significantly higher in treated groups specially in MS/vanillin/stem cells group (P≤0.01), also, the serum levels of the inflammatory factors and IgG were significantly higher in the MS group compare to treated groups (P≤0.01).Conclusion: Administration of vanillin with stem cell transplantation could be a suitable approach to accelerate the process of myelin repair in the nervous tissue.]]></abstract>
				<keyword_fa></keyword_fa>
				<keyword>Adipose derived stem cells, Multiple Sclerosis, Myelin, Oligodendrocyte, Vanillin</keyword>
				<start_page>1027</start_page>
				<end_page>1034</end_page>
				<web_url>https://ijbms.mums.ac.ir/article_27825.html</web_url>
			<author_list><author>
				<first_name>Sara</first_name>
				<middle_name></middle_name>
				<last_name>Gazmeh</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>saragazmeh73@gmail.com</email>
				<code>122339</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Anatomical Sciences and Molecular Biology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Mohammad</first_name>
				<middle_name></middle_name>
				<last_name>Mardani</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>mardani@med.mui.ac.ir</email>
				<code>122338</code>
				<coreauthor>Yes</coreauthor>
				<affiliation>Department of Anatomical Sciences and Molecular Biology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Nazem</first_name>
				<middle_name></middle_name>
				<last_name>Ghasemi</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>n-ghasemi@med.mui.ac.ir</email>
				<code>122340</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Anatomical Sciences and Molecular Biology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author></author_list>
				</article>
			</articleset>
			</journal>